期刊
CANCER SCIENCE
卷 106, 期 10, 页码 1341-1350出版社
WILEY
DOI: 10.1111/cas.12762
关键词
Apoptosis; cell cycle arrest; gallbladder carcinoma; magnolol; p53 pathways
类别
资金
- National Natural Science Foundation of China
- National High Technology Research and Development Program (863 Program)
- Foundation for Interdisciplinary Research of Shanghai Jiao Tong University
- Shanghai Science and Technology Commission Medical-guiding Project
- Natural Science Foundation of Shanxi Province
- Shanghai Rising-Star Program
Magnolol, the major active compound found in Magnolia officinalis has a wide range of clinical applications due to its anti-inflammation and anti-oxidation effects. This study investigated the effects of magnolol on the growth of human gallbladder carcinoma (GBC) cell lines. The results indicated that magnolol could significantly inhibit the growth of GBC cell lines in a dose- and time-dependent manner. Magnolol also blocked cell cycle progression at G(0)/G(1) phase and induced mitochondrial-related apoptosis by upregulating p53 and p21 protein levels and by downregulating cyclin D1, CDC25A, and Cdk2 protein levels. When cells were pretreated with a p53 inhibitor (pifithrin-a), followed by magnolol treatment, pifithrin-a blocked magnolol-induced apoptosis and G(0)/G(1) arrest. In vivo, magnolol suppressed tumor growth and activated the same mechanisms as were activated in vitro. In conclusion, our study is the first to report that magnolol has an inhibitory effect on the growth of GBC cells and that this compound may have potential as a novel therapeutic agent for the treatment of GBC.
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