Review
Endocrinology & Metabolism
Xiaoying Zhang, Caizheng Wang, Jiahui Yu, Jiawen Bu, Fulv Ai, Yue Wang, Jie Lin, Xudong Zhu
Summary: Breast cancer is a major cause of cancer-related death in women. Currently, the lack of targeted therapy limits the treatment options and patients often face higher severity, metastasis, and resistance. Extracellular vesicles (EVs) contain a complex cargo that plays crucial roles in breast cancer initiation and progression. This review focuses on discussing the EV cargoes released from breast cancer cells and tumor-derived EVs in the breast cancer microenvironment, specifically in relation to proliferation, metastasis, chemoresistance, and their potential as biomarkers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Analytical
Xiaowei Wei, Lijun Cai, Hanxu Chen, Luoran Shang, Yuanjin Zhao, Weijian Sun
Summary: This study proposes a novel system for multiplexed analysis of bladder cancer-derived urine exosomes using magnetic microspheres as barcoded microcarriers. The unique structure of the microcarriers allows for controllable movement and high sensitivity detection of exosomes. The noninvasive nature of the platform, combined with its good sensitivity, specificity, low sample consumption, and ease of use, indicates its great potential for bladder cancer diagnosis in clinical applications.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Megan I. Mitchell, Olivier Loudig
Summary: Human tumors are described as a complex ecosystem, consisting of various cell types, growth factors, extracellular matrix components, and microvessels, known as the tumor microenvironment (TME). Tumor-derived extracellular vesicles (EVs) play a crucial role in reprogramming surrounding stromal cells and promoting cancer progression. These EVs are essential for the metastatic dissemination of cancer cells and the formation of pre-metastatic niches.
Review
Oncology
Carolina Saldana, Amene Majidipur, Emma Beaumont, Eric Huet, Alexandre de la Taille, Francis Vacherot, Virginie Firlej, Damien Destouches
Summary: This review highlights the role of extracellular vesicles in therapeutic resistance of advanced prostate cancer and their potential for discovering predictive biomarkers to improve treatment outcomes.
Article
Oncology
Melike Mut, Zelal Adiguzel, Canan Cakir-Aktas, Sahin Hanalioglu, Gamze Gungor-Topcu, Ezgi Kiyga, Ilkay Isikay, Aydan Sarac, Figen Soylemezoglu, Thomas Strobel, Elisabet Ampudia-Mesias, Charles Cameron, Tulay Aslan, Eray Tekirdas, Mutlu Hayran, Kader Karli Oguz, Christine Henzler, Nurten Saydam, Okay Saydam
Summary: In this study, RNA sequencing of serum extracellular vesicles (EVs) was used to identify new tumor markers for glioblastoma. The results showed that serum-EV-based biomarker panels could accurately predict the status of various genetic mutations in glioblastoma, such as IDH1 mutation and MGMT promoter methylation. These biomarkers can be used for early cancer risk prediction and improved patient stratification and treatment strategies. This is the first study to demonstrate the diagnostic potential of serum-EV-based biomarker panels for glioblastoma.
Article
Cardiac & Cardiovascular Systems
Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Summary: Exosomes are small membrane-bound vesicles actively secreted by cells. Research on the potential and challenges of exosomes in biological signaling in myocardial function highlights their significance in cardiac physiology and pathology, emphasizing the need for scientific innovations in isolation and characterization methodologies.
Review
Biochemistry & Molecular Biology
Simita Gaglani, Edgar Gonzalez-Kozlova, Dara J. Lundon, Ashutosh K. Tewari, Navneet Dogra, Natasha Kyprianou
Summary: Extracellular vesicles (EVs) play a crucial role in non-invasive liquid biopsy for cancer detection, with exosomes having significant diagnostic value in prostate cancer and potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Giusi Alberti, Christian M. Sanchez-Lopez, Alexia Andres, Radha Santonocito, Claudia Campanella, Francesco Cappello, Antonio Marcilla
Summary: Tumor cell-derived extracellular vesicles play a crucial role in cancer metastasis by modulating the tumor microenvironment, suppressing the immune system, and forming pre-metastatic niches. These EVs, easily isolated from various biological fluids, serve as valuable biomarkers for cancer diagnosis, prognosis, monitoring cancer progression, and treatment response.
APPLIED SCIENCES-BASEL
(2021)
Review
Biotechnology & Applied Microbiology
Linjin Xiong, Yumeng Wei, Qiang Jia, Jinglin Chen, Tao Chen, Jiyuan Yuan, Chao Pi, Huiyang Liu, Jia Tang, Suyu Yin, Ying Zuo, Xiaomei Zhang, Furong Liu, Hongru Yang, Ling Zhao
Summary: Colorectal cancer is a common and deadly cancer of the digestive tract with high incidence and mortality rates worldwide. Extracellular vesicles (EVs) have been identified as a novel mechanism for intercellular communication, playing a crucial role in the metastasis and drug resistance of CRC. A comprehensive understanding of EVs in CRC could provide a basis for developing therapeutic strategies and their potential as next-generation delivery systems, as well as serving as biomarkers for prediction, diagnosis, and prognosis of CRC.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rafal Szatanek, Monika Baj-Krzyworzeka
Summary: Cancer metastasis involves complex interactions between various cell types and the tumor microenvironment, with tumor cells releasing proteins and nucleic acids through extracellular vesicles to facilitate dissemination. This process plays a crucial role in tumor progression and escape from immune surveillance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Marianna D'Anca, Chiara Fenoglio, Francesca Romana Buccellato, Caterina Visconte, Daniela Galimberti, Elio Scarpini
Summary: Extracellular vesicles (EVs) have evolved from being considered waste disposal tools to playing important roles in intercellular communication, physiological and pathological processes, especially in diseases like multiple sclerosis (MS). EVs not only carry and release bioactive molecules, but also hold potential as new therapeutic tools and sources of biomarkers.
Review
Cell Biology
Defa Huang, Dingyu Rao, Xuxiang Xi, Zuxiong Zhang, Tianyu Zhong
Summary: Extracellular vesicles (EVs) are important cellular secretions that contain proteins that can serve as diagnostic markers for cancer, providing a basis for early tumor diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Giovanna Scioli, Sonia Terriaca, Elena Fiorelli, Gabriele Storti, Giulia Fabbri, Valerio Cervelli, Augusto Orlandi
Summary: Cancer stem cells and extracellular vesicles play crucial roles in tumor growth, progression, metastasis, drug resistance, and disease relapse, making them potential targets for therapy and drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Marian Cruz-Burgos, Sergio A. Cortes-Ramirez, Alberto Losada-Garcia, Miguel Morales-Pacheco, Eduardo Martinez-Martinez, Jorge Gustavo Morales-Montor, Alejandro Servin-Haddad, J. Samuel Izquierdo-Luna, Griselda Rodriguez-Martinez, Maria del Pilar Ramos-Godinez, Vanessa Gonzalez-Covarrubias, Abraham Canavera-Constantino, Imelda Gonzalez-Ramirez, Boyang Su, Hon S. Leong, Mauricio Rodriguez-Dorantes
Summary: Metastasis is the main cause of death in prostate cancer patients. This study investigates the potential diagnostic value of extracellular vesicle-derived microRNAs in liquid biopsies for prostate cancer. Through microarray analysis, differential expression of microRNAs was observed in metastatic lymph nodes compared to prostate tumors and non-metastatic lymph node tissues. Specifically, miR-150-5p shows promise as a diagnostic marker for high-grade Gleason scores and early detection of metastasis.
Article
Cell Biology
Jadwiga Jablonska, Malwina Rist, Ilona Spyra, Luisa Tengler, Maksim Domnich, Benjamin Kansy, Bernd Giebel, Basant Kumar Thakur, Nicole Rotter, Stephan Lang, Sonja Ludwig
Summary: Head and Neck Cancers (HNCs) exhibit highly immunosuppressive properties, and small extracellular vesicles (sEVs) play a role in intercellular communication by carrying immunosuppressive proteins and inhibiting anti-tumor immune responses. This study evaluates immunosuppressive markers on sEVs from HNC patients at different disease stages and follow-up periods. The findings suggest that a combination of immunoregulatory markers should be used to monitor disease progression and therapy response in HNC.
Article
Cell Biology
Haiying Zhang, Daniela Freitas, Han Sang Kim, Kristina Fabijanic, Zhong Li, Haiyan Chen, Milica Tesic Mark, Henrik Molina, Alberto Benito Martin, Linda Bojmar, Justin Fang, Sham Rampersaud, Ayuko Hoshino, Irina Matei, Candia M. Kenific, Miho Nakajima, Anders Peter Mutvei, Pasquale Sansone, Weston Buehring, Huajuan Wang, Juan Pablo Jimenez, Leona Cohen-Gould, Navid Paknejad, Matthew Brendel, Katia Manova-Todorova, Ana Magalhaes, Jose Alexandre Ferreira, Hugo Osorio, Andre M. Silva, Ashish Massey, Juan R. Cubillos-Ruiz, Giuseppe Galletti, Paraskevi Giannakakou, Ana Maria Cuervo, John Blenis, Robert Schwartz, Mary Sue Brady, Hector Peinado, Jacqueline Bromberg, Hiroshi Matsui, Celso A. Reis, David Lyden
NATURE CELL BIOLOGY
(2018)
Article
Biochemical Research Methods
Haiying Zhang, David Lyden
Editorial Material
Cell Biology
Goncalo Rodrigues, Haiying Zhang, David Lyden
NATURE CELL BIOLOGY
(2019)
Editorial Material
Cell Biology
Candia M. Kenific, Haiying Zhang, David Lyden
Editorial Material
Cell Biology
Gang Wang, Haiying Zhang, David Lyden
Summary: The study found that tumor-derived humoral factors induce anorexia earlier than cachexia by dysregulating neuropeptides in the brain.
NATURE CELL BIOLOGY
(2021)