Article
Endocrinology & Metabolism
Anne Peters, Nathan Cohen, Peter Calhoun, Katrina J. Ruedy, Roy W. Beck, Thomas W. Martens, Shichun Bao, Nelly M. Njeru, Stayce E. Beck, David A. Price
Summary: In the MOBILE study, it was found that basal insulin users with suboptimal control of T2D often have inadequate self-monitored blood glucose (SMBG) frequency, leading to issues with hyperglycemia and hypoglycemia management. The study aims to determine the benefits of using real-time continuous glucose monitoring (CGM) compared to SMBG in this population.
DIABETES OBESITY & METABOLISM
(2021)
Article
Medicine, General & Internal
Harpreet S. Bajaj, Jens Aberle, Melanie Davies, Anders Meller Donatsky, Marie Frederiksen, Dilek G. Yavuz, Amoolya Gowda, Ildiko Lingvay, Bruce Bode
Summary: This study compared the effectiveness and safety of icodec titrated with a dosing guide app to once-daily basal insulin analogues in treating patients with type 2 diabetes. The results showed that icodec with app was more effective in reducing HbA1c levels, improving treatment satisfaction and compliance, with similar rates of hypoglycemia compared to OD analogues.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Huiying Wang, Yunting Zhou, Yuming Wang, Tingting Cai, Yun Hu, Ting Jing, Bo Ding, Xiaofei Su, Huiqin Li, Jianhua Ma
Summary: This study examined the glycaemic variability and safety of basal and premixed insulin in patients with type 2 diabetes. The results showed that compared to basal insulin, patients using premixed insulin had higher glycaemic variability, smaller time in range, and increased risk of hypoglycaemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Jiaping Lu, Zhen Ying, Ping Wang, Minjie Fu, Chenyu Han, Min Zhang
Summary: This study aimed to assess the efficacy of continuous glucose monitoring (CGM) compared to self-monitoring of blood glucose (SMBG) in maintaining glycemic control among individuals with type 2 diabetes mellitus (T2DM). The results showed that CGM provided greater benefits in glycemic management compared to SMBG, particularly in patients using real-time CGM.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Mengyu Lai, Jianrong Weng, Jiaying Yang, Yujia Gong, Fang Fang, Na Li, Mei Kang, Xianming Xu, Yufan Wang
Summary: This study evaluated the effect of continuous glucose monitoring (CGM) versus self-monitored blood glucose (SMGB) in gestational diabetes mellitus (GDM) with hemoglobin A1c (HbA1c). The results showed that for GDM patients with HbA1c<6%, regular self-monitored blood glucose is a more economical method and can achieve similar glycemic control as CGM, while CGM is beneficial for ideal gestational weight gain (GWG).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fei Sun, Bin Gao, Aili Yang, Lijun Ren, Ying Xing, Kaiyan Ma, Li Tian, Simin Li, Chunni Heng, Hao Liu, Jie Zhou, Qiuhe Ji
Summary: This study found that using a needle-free insulin injector (NFII) to administer basal insulin improved fasting glucose variability (FGV) in patients with type 2 diabetes mellitus (T2DM), as compared to conventional insulin pen (CIP) injection.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Medicine, General & Internal
Agata Majewska, Pawel Jan Stanirowski, Miroslaw Wielgos, Dorota Bomba-Opon
Summary: Gestational diabetes mellitus (GDM) is a common complication of pregnancy, affecting up to 14% of pregnant women. Continuous glucose monitoring (CGM) has been shown to be safe and effective in improving glycaemic control in GDM. However, more research is needed to analyze the impact of CGM on perinatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jinhua Yan, Yongwen Zhou, Xueying Zheng, Mao Zheng, Jing Lu, Sihui Luo, Daizhi Yang, Hongrong Deng, Wen Xu, Yan Bi, Wei Bao, Jianping Weng
Summary: This study aimed to investigate whether intermittently scanned continuous glucose monitoring without alarms (isCGM) improves glycaemic control over capillary blood glucose monitoring (BGM) among adult type 1 diabetes mellitus (T1DM) patients with suboptimal control. The results showed that compared with BGM, the use of isCGM resulted in a statistically significant improvement in glycaemic control after a 24-week intervention.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Yiqun Liu, Qi Yu, Xiaojin Luo, Li Yang, Yue Cui
Summary: The study demonstrated the continuous monitoring of diabetes using an integrated microneedle biosensing device, which showed accurate sensing performance by inserting into the dermis layer of mouse skin and yielded detection results highly correlated with those from a commercial blood glucose meter.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Endocrinology & Metabolism
Daniel A. Hochfellner, Raphael Rainer, Haris Ziko, Felix Aberer, Amra Simic, Katharina M. Lichtenegger, Peter Beck, Klaus Donsa, Thomas R. Pieber, Friedrich M. Fruhwald, Alexander R. Rosenkranz, Lars-Peter Kamolz, Petra M. Baumann, Julia K. Mader, Johannes Plank
Summary: The study evaluated the efficacy and safety of basal-bolus insulin therapy in managing blood glucose during fasting periods in hospitalized patients with type 2 diabetes. The results showed that blood glucose control during fasting periods was influenced by a reduction in bolus insulin doses.
DIABETES OBESITY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Maryam S. Hafiz, Matthew D. Campbell, Nicolas M. Orsi, Georgia Mappa, Caroline Orfila, Christine Boesch
Summary: This study aimed to determine the effect of mechanical processing on postprandial interstitial glycaemic and satiety responses in humans. The results showed that chickpea consumption elicited low postprandial glycaemic responses and enhanced subjective satiety responses, regardless of processing methods.
Editorial Material
Biochemistry & Molecular Biology
Jeremy Pettus, Schafer C. Boeder, Mark P. Christiansen, Douglas S. Denham, Timothy S. Bailey, Halis K. Akturk, Leslie J. Klaff, Julio Rosenstock, Mickie H. M. Cheng, Bruce W. Bode, Edgar D. Bautista, Ren Xu, Hai Yan, Thai Dung, Satish K. Garg, Samuel Klein
Summary: This study evaluated the safety and efficacy of volagidemab, an antagonistic monoclonal glucagon receptor antibody, as an adjunct to insulin therapy in patients with type 1 diabetes. The results showed that volagidemab reduced daily insulin use and decreased HbA1c levels. However, further research is needed to confirm the long-term efficacy and safety of volagidemab.
Review
Endocrinology & Metabolism
Christine Newman, Adesuwa Ero, Fidelma P. P. Dunne
Summary: Pregestational diabetes (PGDM) is a common and complex condition that poses risks to both mother and infant. Strict glucose control is essential to prevent serious complications. This review examines the available technologies for glucose sensing and insulin delivery in women with PGDM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Cameron Cummings, Alex Jiang, Amanda Sheehan, Rafael Ferraz-Bannitz, Alexa Puleio, Donald C. Simonson, Jonathan M. Dreyfuss, Mary Elizabeth Patti
Summary: Continuous glucose monitoring (CGM) can reduce hypoglycemia in post-bariatric hypoglycemia (PBH) patients. Real-time monitoring helps patients detect hyperglycemic peaks and impending hypoglycemia, allowing for dietary adjustments and self-treatment to reduce the risk of hypoglycemia.
DIABETES OBESITY & METABOLISM
(2023)
Article
Engineering, Chemical
Paolo Trucillo
Summary: This paper is a description of a diabetic patient's experience with the treatment of diabetes using a multi-injection insulin system and an automated insulin administration system. The author compares the advantages and disadvantages of both systems and highlights the importance of educating patients to approach illness treatment in a scientific manner.
Article
Endocrinology & Metabolism
Jorge Lo Presti, Alfonso Galderisi, Francis J. Doyle, Howard C. Zisser, Eyal Dassau, Eric Renard, Chiara Toffanin, Claudio Cobelli
Summary: This study develops a compartmental model of intraperitoneal insulin kinetics and proves the peritoneum to be a virtual space for insulin delivery.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Hannah Forde, Pratik Choudhary, Peter Hammond, Sufyan Hussain
Review
Endocrinology & Metabolism
Moshe Phillip, Revital Nimri, Richard M. Bergenstal, Katharine Barnard-Kelly, Thomas Danne, Roman Hovorka, Boris P. Kovatchev, Laurel H. Messer, Christopher G. Parkin, Louise Ambler-Osborn, Stephanie A. Amiel, Lia Bally, Roy W. Beck, Sarah Biester, Torben Biester, Julia E. Blanchette, Emanuele Bosi, Charlotte K. Boughton, Marc D. Breton, Sue A. Brown, Bruce A. Buckingham, Albert Cai, Anders L. Carlson, Jessica R. Castle, Pratik Choudhary, Kelly L. Close, Claudio Cobelli, Amy B. Criego, Elizabeth Davis, Carine de Beaufort, Martin de Bock, Daniel J. DeSalvo, J. Hans DeVries, Klemen Dovc, Francis J. Doyle, Laya Ekhlaspour, Naama Fisch Shvalb, Gregory P. Forlenza, Geraldine Gallen, Satish K. Garg, Dana C. Gershenoff, Linda A. Gonder-Frederick, Ahmad Haidar, Sara Hartnell, Lutz Heinemann, Simon Heller, Irl B. Hirsch, Korey K. Hood, Diana Isaacs, David C. Klonoff, Olga Kordonouri, Aaron Kowalski, Lori Laffel, Julia Lawton, Rayhan A. Lal, Lalantha Leelarathna, David M. Maahs, Helen R. Murphy, Kirsten Norgaard, David O'Neal, Sean Oser, Tamara Oser, Eric Renard, Michael C. Riddell, David Rodbard, Steven J. Russell, Desmond A. Schatz, Viral N. Shah, Jennifer L. Sherr, Gregg D. Simonson, R. Paul Wadwa, Candice Ward, Stuart A. Weinzimer, Emma G. Wilmot, Tadej Battelino
Summary: The global prevalence of diabetes continues to be a challenge and the advances in automated insulin delivery (AID) technologies have shown to be safe and effective in helping patients achieve their glycemic goals. However, there is a lack of guidance for clinicians on using AID systems in clinical settings.
Review
Endocrinology & Metabolism
Parizad Avari, Alistair Lumb, Daniel Flanagan, Gerry Rayman, Shivani Misra, Pratik Choudhary, Ketan Dhatariya
Summary: This article provides a review and summary of the JBDS-IP guidelines on diabetes technology use in hospitalized patients. It focuses on the use of insulin pumps and hybrid closed-loop systems, highlighting the need for specialist guidance and knowledge of the devices before continuing their use.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Parizad Avari, Alistair Lumb, Daniel Flanagan, Gerry Rayman, Shivani Misra, Ketan Dhatariya, Pratik Choudhary
Summary: The article discusses the increasing use of wearable technologies for managing diabetes, particularly in the hospital setting. It emphasizes the need for clinical guidelines and local policies to support individuals using diabetes technologies and ensure their safe use within healthcare organizations.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Daniel Flanagan, Parizad Avari, Pratik Choudhary, Alistair Lumb, Shivani Misra, Gerry Rayman, Ketan Dhatariya
Summary: The past decade has witnessed a technological revolution that has greatly improved the lives of individuals with diabetes, and this progress also has significant implications for diabetes care within the hospital setting. Technological advancements, including point of care glucose monitoring, electronic prescribing, electronic observations, electronic referral, and electronic health records, offer the potential to enhance diabetes care for inpatients. However, the integration of these tools, as well as the use of pumps and glucose sensors in a hospital setting, requires a novel approach from the diabetes care team. Limited work has been done to explore the combination of these technologies. In this article, we describe how these technologies can be combined to optimize diabetes care in the hospital.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Shideh Majidi, Lauren Cohen, Richard I. G. Holt, Mark Clements, Simon O'Neill, Eric Renard, Doug Tynan, Diana Naranjo, Laurel H. Messer, David C. Klonoff, Katharine Barnard-Kelly
Summary: People with diabetes have a higher risk of depression, intentional self-injury, and suicide. This study investigates the experiences and awareness of healthcare professionals (HCPs) regarding these issues, as well as their resource needs. A survey was conducted with 129 HCPs who care for individuals with type 1 or type 2 diabetes. The results show that a majority of HCPs feel uncomfortable asking about self-injury or suicidal ideation and lack appropriate training. They express a need for more training on how to address these issues and better access to resources for patients with diabetes.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Genetics & Heredity
Matej Mlinaric, James R. Bonham, Viktor Kozich, Stefan Koelker, Ondrej Majek, Tadej Battelino, Ana Drole Torkar, Vanesa Koracin, Dasa Perko, Ziga Iztok Remec, Barbka Repic Lampret, Maurizio Scarpa, Peter C. J. I. Schielen, Rolf H. Zetterstrom, Urh Groselj
Summary: The COVID-19 pandemic had negative impacts on the newborn screening programs, causing missed cases of inherited metabolic diseases due to decreased diagnostic quality. Contingency plans were implemented to address the problems emerged at the start of the pandemic, including staff shortage and modified work schedules. Adaptations and modifications were made in sample collection, resource sharing, and telemedicine utilization to ensure the continuity of the screening programs.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2023)
Article
Endocrinology & Metabolism
Thomas S. J. Crabtree, Tomas P. Griffin, Yew W. Yap, Parth Narendran, Geraldine Gallen, Niall Furlong, Iain Cranston, Ali Chakera, Chris Philbey, Muhammad Ali Karamat, Sanjay Saraf, Shafie Kamaruddin, Eleanor Gurnell, Alyson Chapman, Sufyan Hussain, Jackie Elliott, Lalantha Leelarathna, Robert E. J. Ryder, Peter Hammond, Alistair Lumb, Pratik Choudharyq, Emma G. Wilmot
Summary: The study found that switching to hybrid closed-loop (HCL) insulin delivery systems led to improvements in HbA1c, time in range, hypoglycemia, and quality of life in adults with type 1 diabetes, despite previous use of intermittently scanned continuous glucose monitoring and insulin pump therapy.
Article
Endocrinology & Metabolism
Shannon Edd, Javier Castaneda, Pratik Choudhary, Ralf Kolassa, Winfried Keuthage, Jens Kroeger, Charles Thivolet, Mark Evans, Roseline Re, Jessica Cellot, Simona de Portu, Linda Vorrink, John Shin, Tim van den Heuvel, Ohad Cohen, ADAPT Study Grp
Summary: The study aimed to assess the 6-month and 12-month sustained efficacy of the MiniMedT 780G advanced hybrid closed-loop automated insulin delivery system compared to MDI+isCGM therapy in type 1 diabetes patients not meeting glucose targets. The results showed that AID therapy can continuously improve glycemic control during the continuation phase, supporting the early adoption of AID therapy.
DIABETES OBESITY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Maja Berlic, Tadej Battelino, Mojca Korosec
Summary: This study aimed to investigate whether a meticulously crafted meal plan could effectively enhance the daily intake of nutritious foods for kindergarten children. The findings showed that the meal plan adhering to dietary guidelines significantly improved the intake of vegetables, whole grains, and nuts in kindergarten children. Importantly, only meals consumed within the kindergarten setting had a significant effect on overall intake.
Article
Biochemistry & Molecular Biology
Antonietta Robino, Gianluca Tornese, Davide Tinti, Klemen Dovc, Valeria Castorani, Andrea Conti, Roberto Franceschi, Ivana Rabbone, Riccardo Bonfanti, Tadej Battelino, Eulalia Catamo
Summary: This study investigated the association between HNF1A gene SNPs and type 1 diabetes (T1D) susceptibility. The study found that one of the SNPs was associated with insulin dose-adjusted glycated hemoglobin A1c (IDAA1c) and glycated hemoglobin (HbA1c) values. These findings suggest that HNF1A variants may be a risk factor for beta cell function and glycaemic control in individuals with T1D.
Article
Endocrinology & Metabolism
Daphne Gardner, Hong Chang Tan, Gek Hsiang Lim, May Zin Oo, Xiaohui Xin, Andrew Kingsworth, Pratik Choudhary, Suresh Rama Chandran
Summary: Daytime physical activity increases the risk of nocturnal hypoglycemia in people with type 1 diabetes, and this risk can be assessed using a smartphone-based step tracker.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Eric Renard
Summary: Automated insulin delivery systems, known as closed-loop systems or artificial pancreas, use blood glucose levels to drive insulin supply, resulting in improved blood sugar control and reduced risk of hypoglycemia for type 1 diabetes patients. Although current AID systems require meal and exercise announcements for insulin adjustment, they represent a significant milestone in diabetes treatment and pave the way for future fully automated and more physiological closed-loop systems.
ACTA DIABETOLOGICA
(2023)