Article
Oncology
Mariana Morais, Francisca Dias, Ines Nogueira, Anabela Leao, Nuno Goncalves, Luis Araujo, Sara Granja, Fatima Baltazar, Ana L. Teixeira, Rui Medeiros
Summary: Renal cell carcinoma (RCC) is a metabolic associated cancer, and this study investigated the potential role of hsa-miR-144-5p and hsa-miR-186-3p in ccRCC glycolysis status and as biomarkers. Circulating hsa-miR-144-5p and hsa-miR-186-3p could be potential biomarkers of ccRCC prognosis.
Article
Cell Biology
Zhiliang Chen, Zaosong Zheng, Yingwei Xie, Qiyu Zhong, Wentai Shangguan, Yishan Zhang, Dingjun Zhu, Wenlian Xie
Summary: circPPP6R3 is a highly expressed circular RNA in clear cell renal cell carcinoma (ccRCC), and it is associated with the severity and progression of the disease. It interacts with miR-1238-3p and upregulates the expression of CD44, promoting cancer cell proliferation and metastasis. This study provides new insights into biomarkers and potential therapeutic approaches for ccRCC.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Bin Meng, Pengfei Wang, Chaofei Zhao, Guangwei Yin, Xin Meng, Lin Li, Shengyong Cai, Chengquan Yan
Summary: This study reveals the stimulatory role of miR-21-5p in renal cell carcinoma and its contribution to the progression of the disease through the modulation of its downstream target gene ARHGAP24 expression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Wei Lv, Yan Li, Liye Fu, Fandong Meng, Jun Li
Summary: This study found that the expression levels of linc01133 were significantly increased in RCC tissues, and overexpression of linc01133 promoted cell proliferation, migration, and invasion while interference of linc01133 inhibited these processes.
Article
Oncology
Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Xiaolong Xiao, Yifei Liu
Summary: Our study reveals that miR-129-5p is down-regulated and SPN is up-regulated in ccRCC. Overexpressed miR-129-5p inhibits cell proliferation, migration, and invasion, induces cell cycle arrest, and promotes apoptosis. Dual-luciferase assay confirms the binding relationship between miR-129-5p and SPN, suggesting a potential target for precise treatment of ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Li-Xin Ren, Bo-Wen Zeng, Meng Zhu, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang, Jun-Fei Gu, Zhan Yang
Summary: The study revealed that downregulation of ZNF304 in ccRCC tissues was associated with poor survival, promoting cell growth, whereas upregulation of miR-183-5p repressed FOXO4 expression and facilitated ccRCC progression. The ZNF304/miR-183-5p/FOXO4 axis played a crucial role in promoting ccRCC progression, suggesting it may be a potential therapeutic target in ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jingyu Zhang, Qingbo Lu, Haigang Pang, Min Zhang, Wenhai Wei
Summary: miR-103a-3p promotes renal cell carcinoma cell progression by regulating TMEM33. This finding may offer new insights into the identification of prognostic markers and therapeutic targets for RCC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Genetics & Heredity
Alexander J. Thompson, Yousef M. Alwan, Vijay A. C. Ramani, D. Gareth Evans, Eamonn R. Maher, Emma R. Woodward
Summary: The purpose of this study was to determine the cost-effectiveness of annual renal imaging surveillance (RIS) in hereditary leiomyomatosis and renal cell cancer (HLRCC). The study found that annual contrast-enhanced renal MRI surveillance (CERMRIS) in HLRCC is cost-effective across different age groups.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Cheng-Peng Gui, Bing Liao, Cheng-Gong Luo, Yu-Hang Chen, Lei Tan, Yi-Ming Tang, Jia-Ying Li, Yi Hou, Hong-De Song, Hai-Shan Lin, Quan-Hui Xu, Gao-Sheng Yao, Hao-Hua Yao, Xi-Liu, Jun-Hang Luo, Jia-Zheng Cao, Jin-Huan Wei
Summary: The study identified circCHST15 as a potential prognostic biomarker and therapeutic target for ccRCC, demonstrating its role in promoting proliferation, migration, and invasion of ccRCC cells by sponging miR-125a-5p to regulate EIF4EBP1 expression. CircCHST15 was found to be highly expressed in ccRCC tissues and cell lines, correlating with aggressive clinicopathological characteristics and serving as an independent prognostic indicator for overall survival and progression-free survival in patients with ccRCC after surgical resection. The study suggests further investigation of circCHST15 for its clinical implications in ccRCC management.
Article
Oncology
Shuangjie Liu, Lei Dou, Miao Miao, Xiaojun Man, Baojun Wei, Zhaowei Jiang, Yongze Ouyang, Toshinori Ozaki, Meng Yu, Yuyan Zhu
Summary: miR-138-2 functions as a novel epigenetic regulator of pro-oncogenic NOTCH1 pathway in renal cell carcinoma (RCC). It directly targets APH1A, MAML1, and NOTCH1 for the synergistic inhibition of NOTCH1 signaling. The feedback regulatory loop composed of HES1, miR-138-2, and NOTCH1 contributes to the malignant development of RCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Guangjie Hou, Junfeng Yang, Jinxing Tang, Yi He
Summary: In this study, the new long non-coding RNA GAS6-AS2 was identified in non-small cell lung cancer (NSCLC) and its role in regulating proliferation of NSCLC cells was investigated. Results showed that GAS6-AS2 could function as a competitive endogenous RNA (ceRNA) by sponging miR-144-3p, further regulating the expression of MAPK6. Knockdown of GAS6-AS2 greatly suppressed tumor growth of NSCLC in vivo, suggesting GAS6-AS2 as an effective therapeutic target in NSCLC.
Article
Cell Biology
Guang-Xin Zhong, Dan Luo, Yi-jun Fan, Jue Wang, Bing-Qiang Liu, Zhong-Hua Xu, Xiang Zhang
Summary: DGCR5 isoform-1 is highly expressed in ccRCC and exerts a tumor-promoting effect by sequestering miR-211-5p and regulating Snail protein expression, thereby promoting proliferation and migration of ccRCC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yiguan Qian, Yang Li, Luwei Xu, Ke Chen, Ning Liu, Xiaobing Yang, Qian Lv, Rongfei Li, Changcheng Zhou, Zheng Xu, Ruipeng Jia, Yu-Zheng Ge
Summary: In this study, a novel circRNA called circ-PRKCI was found to promote the proliferation of renal cell carcinoma (RCC) through the miR-545-3p/CCND1 signaling pathway. It was also discovered that tumor cell-derived exosomal circ-PRKCI could enhance the proliferation, migration, and invasion of RCC cells while inhibiting apoptosis. This study provides new insights into the molecular mechanisms of RCC progression.
Article
Cell Biology
Renbo Guo, Benkui Zou, Yiran Liang, Jiasheng Bian, Jian Xu, Qian Zhou, Chao Zhang, Tao Chen, Mingshan Yang, Huansheng Wang, Fajun Pei, Zhonghua Xu
Summary: This study identified an uncharacterized and upregulated lncRNA RCAT1 in renal cell carcinoma, which played a key role in cell proliferation and metastasis by modulating the miR-214-5p/E2F2 axis, suggesting that lncRNA RCAT1 might be a new prognostic biomarker and potential therapeutic target for renal cell carcinoma.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Asmaa Y. Abuhamad, Nurul Nadia Mohamad Zamberi, Sakari Vanharanta, Siti Nur Hasanah Mohd Yusuf, M. Aiman Mohtar, Saiful Effendi Syafruddin
Summary: This study found that clear cell renal cell carcinoma (ccRCC) cells are able to secrete PDGFB, which can activate the mTORC1 signaling pathway and promote the development of ccRCC. The level of PDGFB secretion was positively correlated with the expression of intracellular KLF6 and PDGFB. Reintroduction of either KLF6 or PDGFB sustained mTORC1 signaling activity in KLF6-targeted ccRCC cells. Conditioned media of PDGFB-overexpressing ccRCC cells was able to re-activate mTORC1 activity in KLF6-targeted cells. Cancer cell-derived PDGFB can mediate mTORC1 signaling pathway activation in ccRCC, further solidifying the association between the KLF6-PDGFB axis and mTORC1 signaling pathway activity in ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)