Article
Gastroenterology & Hepatology
Heinz Zoller, Benedikt Schaefer, Annick Vanclooster, Bill Griffiths, Edouard Bardou-Jacquet, Elena Corradini, Graca Porto, John Ryan, Markus Cornberg
Summary: Haemochromatosis is a disease that mainly affects the liver and can lead to complications if left untreated. Early diagnosis and treatment are crucial for preventing further damage. Diagnosis can be made based on specific genetic factors or through imaging and biopsy for other cases.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
European Assoc Study Liver, Richard Moreau, Marta Tonon, Aleksander Krag, Paolo Angeli, Marina Berenguer, Annalisa Berzigotti, Javier Fernandez, Claire Francoz, Thierry Gustot, Rajiv Jalan, Maria Papp, Jonel Trebicka
Summary: Acute-on-chronic liver failure (ACLF) is a severe form of acutely decompensated cirrhosis characterized by organ system failure(s) and high short-term mortality. Patients with ACLF may benefit from liver transplantation and should be promptly stabilized for transplantation by treating identified precipitants and providing intensive care support. These guidelines aim to help clinicians recognize ACLF, make triage decisions, manage acute precipitants, support organ systems, determine futility of intensive care, and identify potential indications for liver transplantation.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Summary: The advancements in radiological imaging techniques have improved the diagnosis of cystic liver lesions. Over the past decades, there has been a matured evidence base supporting the management of these diseases, necessitating comprehensive clinical guidance. This article provides recommendations for the diagnosis and management of various cystic liver diseases, graded according to the Oxford Centre for Evidence-Based Medicine system, with the aim of aiding clinical decision-making process.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
European Assoc Study Liver, Catherine Williamson, Melanie Nana, Liona Poon, Limas Kupcinskas, Rebecca Painter, Gloria Taliani, Michael Heneghan, Hanns-Ulrich Marschall, Ulrich Beuers
Summary: Liver diseases in pregnancy, whether gestational or pre-existing, pose significant risks to both mothers and fetuses. In order to provide recommendations for the management of liver disease in pregnancy, the European Association for the Study of Liver Disease has developed clinical practice guidelines, utilizing the best available evidence, for healthcare professionals involved in the care of pregnant women with liver diseases.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
European Assoc Study Live, Domenico Alvaro, Gregory J. Gores, Joel Walicki, Cesare Hassan, Gonzalo Sapisochin, Mina Komuta, Alejandro Forner, Juan W. Valle, Andrea Laghi, Sumera I. Ilyas, Joong-Won Park, Robin K. Kelley, Maria Reig, Bruno Sangro
Summary: Intrahepatic cholangiocarcinoma (iCCA) is a type of liver cancer that develops between bile ductules and the second-order bile ducts. It is the second most common primary liver cancer and its global incidence is increasing. iCCA has a high mortality rate due to its silent presentation, aggressive nature, and resistance to treatment. The challenges in managing iCCA include its heterogeneity at various levels and the need for early diagnosis, accurate staging, and personalized multidisciplinary treatments. Recent advances in molecular characterization, surgical management, and targeted therapy are promising in improving the outcomes for iCCA patients, and international guidelines have been developed for physicians involved in its management.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
European Assoc Study Liver
Summary: This article presents guidelines for the management of primary or secondary sclerosing cholangitis, covering topics such as diagnostic methods, prognostic assessment, early detection of complications, optimal care pathways, and therapeutic options for both adults and children.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sara Montagnese, Pierre-Emmanuel Rautou, Manuel Romero-Gomez, Fin Stolze Larsen, Debbie L. Shawcross, Dominique Thabut, Hendrik Vilstrup, Karin Weissenborn
Summary: The EASL Clinical Practice Guidelines on the management of hepatic encephalopathy provide evidence-based answers to questions about its definition, diagnosis, differential diagnosis, and treatment. However, it does not cover the pathophysiology of hepatic encephalopathy or all available treatment options.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
European Assoc Study Liver
Summary: Hepatitis D virus (HDV) is a defective virus that relies on hepatitis B virus to cause liver damage. It is highly aggressive and responsible for rare acute and chronic liver diseases. Acute infection can lead to liver failure, while persistent infection is associated with rapid progression to cirrhosis and its complications.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Jean-Charles Nault, Valerie Paradis, Maxime Ronot, Jessica Zucman-Rossi
Summary: Advancements in the understanding of the pathophysiology of benign liver nodules have led to refinements in their classification. New diagnostic criteria using imaging, histology, and molecular analyses have improved the accuracy of diagnosis for these tumors and have influenced patient management.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Annalisa Berzigotti, Emmanouil Tsochatzis, Jerome Boursier, Laurent Castera, Nora Cazzagon, Mireen Friedrich-Rust, Salvatore Petta, Maja Thiele
Summary: The article provides the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for assessing liver disease severity and prognosis, with a focus on topics with relevant evidence published in the last 5 years.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike
Summary: The latest edition of the clinical practice guidelines for liver cirrhosis includes new background and future research questions, as well as updates based on international standards and recent findings. It covers various aspects of liver cirrhosis treatment, complication management, and clinically important issues, incorporating the latest information and references to international guidelines.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike
Summary: The latest edition of the clinical practice guidelines for liver cirrhosis integrates new findings in clinical treatment, aligns with international standards, and includes data based on clinical practice evidence from Japan. The guidelines encompass new approaches to diagnosis, treatment, and management of complications, with detailed explanations on topics such as nutritional therapy.
HEPATOLOGY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Erica Villa, Marcello Bianchini, Annabel Blasi, Alban Denys, Edoardo G. Giannini, Andrea de Gottardi, Ton Lisman, Emmanuelle de Raucourt, Cristina Ripoll, Pierre-Emmanuel Rautou
Summary: This article discusses the challenging issues of bleeding and thrombosis prevention and management in patients with cirrhosis, providing practical guidance. Some recommendations in this document are based on the panel's view that certain commonly used interventions are not useful.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Shoji Kubo, Hiroji Shinkawa, Yoshinari Asaoka, Tatsuya Ioka, Hiroshi Igaki, Namiki Izumi, Takao Itoi, Michiaki Unno, Masayuki Ohtsuka, Takuji Okusaka, Masumi Kadoya, Masatoshi Kudo, Takashi Kumada, Norihiro Kokudo, Michiie Sakamoto, Yoshihiro Sakamoto, Hideyuki Sakurai, Tadatoshi Takayama, Osamu Nakashima, Yasushi Nagata, Etsuro Hatano, Kenichi Harada, Takamichi Murakami, Masakazu Yamamoto
Summary: This paper presents the first version of clinical practice guidelines for intrahepatic cholangiocarcinoma (ICC) established by the Liver Cancer Study Group of Japan. The guidelines cover various aspects of ICC, including etiology, pathology, diagnosis, and treatment, and provide a treatment algorithm and background statements.
Article
Gastroenterology & Hepatology
Jean-Charles Nault, Jean-Frederic Blanc, Lucile Moga, Julien Calderaro, Thong Dao, Boris Guiu, Arnaud Hocquelet, Valerie Paradis, Ephrem Salame, Victor de Ledinghen, Marc Bourliere, Christophe Bureau, Nathalie Ganne-Carrie
Summary: Hepatocellular benign liver tumors, including hepatic hemangioma, focal nodular hyperplasia, and hepatocellular adenoma, can be diagnosed using non-invasive criteria such as liver ultrasonography or contrast-enhanced MRI. Hepatocellular adenomas should be managed based on tumor size, gender, and molecular subtypes.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jihyun An, Deokhoon Kim, Bora Oh, Yoo-Jin Oh, Jihyun Song, Naomi Park, Ha Il Kim, Hyo Jeong Kang, Ji-Hye Oh, Wonkyung Kim, Eunjung Lee, Chang Ohk Sung, Gi-Won Song, Dae-Ghon Kim, Eunsil Yu, Eric Letouze, Jessica Zucman-Rossi, Han Chu Lee, Ju Hyun Shim
Summary: This study identified the landscape and mechanisms of HBV integration in iCCA tumors, revealing recurrent viral integration breakpoints at multiple sites including TERT and FAT2, and oncogenic effects through intergenic insertions activating the mTOR pathway. The mutational profiles of HBV-iCCA were found to be more similar to nonviral conventional iCCA, rather than HBV-related liver cancers like HBV-HCC and HBV-cHCC/CCA.
Article
Oncology
Haonan Lu, Jacob George, Mohammed Eslam, Augusto Villanueva, Luigi Bolondi, Helen L. Reeves, Misti McCain, Edward Chambers, Caroline Ward, Dewi Sartika, Caroline Sands, Lynn Maslen, Matthew R. Lewis, Ramya Ramaswami, Rohini Sharma
Summary: The burden of metabolic associated fatty liver disease (MAFLD) is increasing, along with an increase in hepatocellular cancer (HCC). The characteristic features of MAFLD and its sequelae include disturbances in lipid handling, inflammation, and mitochondrial damage. This study aimed to identify a predictive model for HCC by analyzing the profile of circulating lipid and small molecule metabolites in MAFLD patients.
Article
Gastroenterology & Hepatology
Helen L. Reeves, John Reicher, Georgia Priona, Derek M. Manas, Peter Littler
Summary: SIRT treatment for advanced HCC shows promising outcomes, bridging patients with adverse predictive factors to subsequent surgery or medical therapies. However, the role of SIRT after TACE or in BCLC-C patients needs further assessment.
FRONTLINE GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jules Gregory, Lambros Tselikas, Caroline Allimant, Thierry de Baere, Irene Bargellini, Jon Bell, Jose Ignacio Bilbao, Antoine Bouvier, Julius Chapiro, Carlo Chiesa, Thomas Decaens, Alban Denys, Rafael Duran, Julien Edeline, Etienne Garin, Julien Ghelfi, Thomas Helmberger, Farah Irani, Marnix Lam, Robert Lewandowski, David Liu, Romaric Loffroy, David C. Madoff, Charles Mastier, Riad Salem, Bruno Sangro, Daniel Sze, Valerie Vilgrain, Michael Vouche, Boris Guiu, Maxime Ronot
Summary: This study aimed to define a textbook outcome (TO) for selective internal radiation therapy (SIRT) of hepatocellular carcinoma. The final TO, determined through expert opinions and an international survey, is a multidimensional standardization tool suitable for routine care, clinical round, and research.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Gastroenterology & Hepatology
Alix Demory, Jean-Marie Peron, Julien Calderaro, Janick Selves, Fatima-Zohra Mokrane, Giuliana Amaddeo, Valerie Paradis, Marianne Ziol, Olivier Sutter, Lorraine Blaise, Nathalie Ganne-Carrie, Valerie Vilgrain, Francois Cauchy, Jessica Zucman-Rossi, Maxime Ronot, Jean-Charles Nault
Summary: This study aims to describe the natural history of hepatocellular adenomas (HCAs) and identify predictive factors for HCA evolution after discontinuation of estrogen-based contraception. The results show that weight variation is strongly associated with the radiological evolution of HCAs, and an estrogen exposure score can predict the regression of HCAs.
Article
Health Policy & Services
Perrine Crequit, Alexandre Vivot, Jules Gregory, Bernard Milleron
Summary: This study assessed the impact of sponsoring by cooperative groups on the availability of results of academic randomized trials in oncology in France. The study found that the involvement of cooperative groups can increase the availability of trial results.
JOURNAL OF CANCER POLICY
(2022)
Article
Biochemistry & Molecular Biology
Chalermsin Permtermsin, H. Lalchungnunga, Sirintra Nakjang, John Casement, Laura Frances Ogle, Helen L. L. Reeves, Gordon Strathdee, Ruchi Shukla
Summary: Hepatocellular carcinoma (HCC) is a common and deadly form of liver cancer. Current treatments are not effective and have significant side effects. A new method using bioinformatics has been developed to identify genes that are necessary for the survival of specific molecular subgroups of HCC but not normal cells. By targeting these genes, it may be possible to induce synthetic lethality in cancer cells. One gene, TIAM1, has been identified as a potential therapeutic target in a specific subgroup of HCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Alessio Aghemo, Alejandro Forner, Luca Valenti
LIVER INTERNATIONAL
(2023)
Review
Oncology
Koen C. van Son, Lars Verschuren, Roeland Hanemaaijer, Helen Reeves, R. Bart Takkenberg, Joost P. H. Drenth, Maarten E. Tushuizen, Adriaan G. Holleboom
Summary: The incidence of hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD) has increased. NAFLD-related HCC is often detected late and is more advanced at diagnosis, leading to limited treatment options. In addition to hepatocytes, immune cells and cells involved in connective tissue formation also play important roles in the development of NAFLD-related HCC.
Article
Oncology
Sergio Munoz-Martinez, Victor Sapena, Angeles Garcia-Criado, Anna Darnell, Alejandro Forner, Ernest Belmonte, Marco Sanduzzi-Zamparelli, Jordi Rimola, Alexandre Soler, Neus Llarch, Gemma Iserte, Ezequiel Mauro, Carmen Ayuso, Jose Rios, Jordi Bruix, Ramon Vilana, Maria Reig
Summary: Patients with early-stage BCLC 0/A hepatocellular carcinoma (HCC) who are not candidates for liver transplantation or resection are treated with percutaneous ablation according to guidelines. However, these patients are at high risk of HCC recurrence and comorbidities can significantly increase the risk of death. This study provides valuable prognosis information for physicians and researchers by analyzing the outcome of HCC patients treated with ablation and considering non-liver comorbidities in treatment decision-making.
Review
Oncology
Ezequiel Mauro, Joana Ferrer-Fabrega, Tamara Sauri, Alexandre Soler, Amparo Cobo, Marta Burrel, Gemma Iserte, Alejandro Forner
Summary: Cholangiocarcinoma (CCA) is a highly lethal neoplasia with increasing incidence. Although surgical resection is the main treatment, it is only successful in one third of patients and has a high risk of recurrence. Other therapeutic strategies like liver transplantation, locoregional treatments, and new chemotherapy schemes based on immunotherapy or targeted therapies have potential to improve overall survival. However, more collaborative efforts and high-quality studies are needed to investigate their use and applicability.
Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Editorial Material
Gastroenterology & Hepatology
Ezequiel Mauro, Alejandro Forner
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
