Article
Biochemistry & Molecular Biology
Hao Chen, Tara McKeen, Xiaojuan Chao, Allen Chen, Fengyan Deng, Hartmut Jaeschke, Wen-Xing Ding, Hong-Min Ni
Summary: Alcohol-related liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the primary causes of chronic liver disease in western countries. Liver transplantation is an effective method to save patients with liver failure. This study found that Necroptosis plays an important role in the hepatic ischemia-reperfusion injury in alcohol-induced steatotic livers.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zongyong Zhang, Tengfei Ma, Zhengyi Fu, Yu Feng, Zhen Wang, Song Tian, Zhen Liu, Wei Wei, Xiang Li, Jincao Chen, Wenyuan Zhao
Summary: TBC1Domain Family Member 25 (TBC1D25) plays a crucial role in brain ischemia-reperfusion (I/R) injury, with its deficiency exacerbating neuronal loss, apoptosis, and inflammation. The protective mechanism of TBC1D25 relies on the regulation of the TAK1-JNK/p38 signaling pathway.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Oncology
Desislava Germanova, Jiri Keirsse, Arnaud Kohler, Jean-Francois Hastir, Peter Demetter, Sandrine Delbauve, Yvon Elkrim, Laurine Verset, Lionel Larbanoix, Nicolas Preyat, Sophie Laurent, Sergei Nedospasov, Vincent Donckier, Jo A. Van Ginderachter, Veronique Flamand
Summary: Liver ischemia-reperfusion injury following hepatic resection in patients with metastases can lead to tumor relapse, with the death of Kupffer cells and recruitment of monocytes possibly playing key roles.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Immunology
Yun-Hai Luo, Zuo-Tian Huang, Ke-Zhen Zong, Zhen-Rui Cao, Da-Di Peng, Bao-Yong Zhou, Ai Shen, Ping Yan, Zhong-Jun Wu
Summary: The study identified miR-194- suppressed PHLDA1 as a critical intersection of dual inflammatory signals in hepatic IRI, showing that PHLDA1 upregulation could lead to liver pathological injury, apoptosis, and cytokine release. Overexpression of miR-194 decreased PHLDA1, alleviating the damage, and further enrichment of PHLDA1 reversed this effect.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Holly Ingram, Murat Dogan, James D. Eason, Cem Kuscu, Canan Kuscu
Summary: Hepatic ischemia-reperfusion injury (IRI) is a major factor in early allograft dysfunction in liver transplantation. miRNAs have been shown to play a crucial role in regulating gene expression and can be manipulated to attenuate liver damage and improve patient outcomes.
Article
Cell Biology
Qianzhen Zhang, Chenxi Piao, Jiayuan Xu, Yue Wang, Tao Liu, Haiyang Ma, Hongbin Wang
Summary: This study investigated the hepatoprotective effect of adipose-derived stem cell exosomes (ADSCs-exo) in hepatic ischemia-reperfusion (I/R) injury in rats and explored the underlying mechanism. The results showed that ADSCs-exo treatment improved liver histomorphology and hepatocyte ultrastructure, and significantly decreased the expression of inflammatory factors. Furthermore, ADSCs-exo protected against hepatic I/R injury by inhibiting endoplasmic reticulum stress (ERS) and inflammation. Therefore, ADSCs-exo can be considered a promising therapeutic option for hepatic I/R injury.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Plant Sciences
Yeting Zhang, Xiangli Zhao, Yunfang Cao, Ming Chen, Zhengyi Shi, Meng Wu, Hao Feng, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Gang Chen, Changxing Qi, Yonghui Zhang
Summary: In this study, eight indole alkaloids were isolated from the endophytic fungus Aspergillus amoenus TJ507, including a previously undescribed compound named amoenamide D. Among these alkaloids, notoamide Q showed significant anti-hypoxia injury activity and could prevent liver damage and hepatocellular apoptosis induced by hepatic ischemia/reperfusion injury. Therefore, notoamide Q may serve as a potential lead compound for preventing hepatic ischemia/reperfusion injury.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Hang Yang, Zuotian Huang, Yunhai Luo, Dengliang Lei, Ping Yan, Ai Shen, Wenbin Liu, Dewei Li, Zhongjun Wu
Summary: This study reveals that TRIM37 plays a role in hepatic ischemia/reperfusion (I/R) injury by enhancing inflammation and promoting cell death. Targeting TRIM37 might be a potential treatment strategy against hepatic I/R injury.
MOLECULAR MEDICINE
(2023)
Article
Anesthesiology
Yi-Nan Zhang, Ze-Nan Chang, Zi-Meng Liu, Shi-Hong Wen, Ya-Qing Zhan, Han-Jin Lai, Hu-Fei Zhang, Yi Guo, Xu-Yu Zhang
Summary: Intestinal ischemia/reperfusion (I/R) challenge leads to gut barrier dysfunction and distant organ injury. Dexmedetomidine can protect against this damage and minimize gut-vascular barrier (GVB) and liver injuries in mice.
ANESTHESIA AND ANALGESIA
(2022)
Article
Immunology
Ting-Ting Li, Yun-Hai Luo, Hang Yang, Hao Chai, Zi-Lun Lei, Da-Di Peng, Zhong-Jun Wu, Zuo-Tian Huang
Summary: The study revealed the significant role of FBXW5 in liver ischemia/reperfusion injury by influencing cell signaling pathways and inducing apoptosis through inflammation response. Therefore, the joint intervention of FBXW5 and mTOR could be a promising strategy to protect the liver from IRI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Abhishek Sahu, Jin Jeon, Min Suk Lee, Hee Seok Yang, Giyoong Tae
Summary: Mesenchymal stem cell (MSC) based therapy shows great potential in treating diseases, but the low viability of transplanted cells in injured tissues due to high oxidative stress levels is a major obstacle. Using a ROS-scavenging nanozyme to protect MSCs from oxidative stress-mediated apoptosis can significantly improve therapeutic potential and survival in high oxidative stress conditions. Incorporating nanozymes into MSCs is a simple and efficient way to enhance MSC-based cell therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Immunology
Miao Huang, Hao Cai, Bing Han, Yuhan Xia, Xiaoni Kong, Jinyang Gu
Summary: NK cells play an important role in the pathogenesis of liver ischemia-reperfusion injury and can exacerbate the damage caused by this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Aiping Jin, Qianrong Zhang, Haijuan Cheng, Cuiling Yang, Xinyan Wang
Summary: This study found that knockdown of circ_0050908 can reduce apoptosis, inflammatory response, and oxidative stress in cardiomyocytes through the miR-324-5p/TRAF3 axis, protecting cardiomyocytes against I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Minglei Bi, Danyi Li, Jin Zhang
Summary: Ischemia-reperfusion injury (IRI) is a common pathological process after organ transplantations, and the damage caused by IRI is often ignored. Curcumin, a polyphenol compound, has been shown to have protective effects against IRI through its anti-oxidative stress, anti-inflammation and anti-apoptosis properties. However, there are still controversies about the underlying mechanisms of curcumin's effects on IRI. This review aims to summarize the protective role of curcumin against IRI and clarify its underlying mechanisms, providing a novel idea for the therapy of IRI.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Neurosciences
Maria-Adriana Neag, Andrei-Otto Mitre, Codrin-Constantin Burlacu, Andreea-Ioana Inceu, Carina Mihu, Carmen-Stanca Melincovici, Marius Bichescu, Anca-Dana Buzoianu
Summary: Micro RNAs (miRNAs) play a crucial role in regulating protein synthesis during cerebral ischemia-reperfusion injuries. Understanding the signaling and modulating effects of miRNAs in this context could lead to the development of neuroprotective agents.
FRONTIERS IN NEUROSCIENCE
(2022)