A novel composition of bioactive glass with potent haemostatic action and antibacterial competence

Haemorrhagic bleeding is a crucial area of concern related to military as well as civilian trauma. In recent years, bioactive glass is gaining attention in a number of healthcare applications, including haemostasis. Herewith, we report a unique composition of bioactive glass, 70 SiO2: (30-x-y) CaO: x.Al2O3: y.ZnO, where x = 10-18 mole% and y = 0-8 mole%, (Al-BAG) exhibiting haemostatic property as well as antibacterial activity. The as-prepared glass was characterized using XRD, SEM-EDX, FTIR and TG-DSC along with in-vitro degradation study and biological studies e.g., cytocompatibility, haemocompatibility, in-vitro thrombus formation, in-vitro blood ab-sorption capacity, blood coagulation assays (PT, aPTT), in-vitro antibacterial assay against Staph. aureus as well as in-vivo acute dermal toxicity followed by histopathological analysis) and in-vivo haemostasis efficacy were un-dertaken. The novel bioactive glass composition exhibits promises to be an efficient haemostatic agent with antibacterial activity.

Automated summary

This study reports a unique composition of bioactive glass, 70 SiO2: (30-x-y) CaO: x.Al2O3: y.ZnO, where x = 10-18 mole% and y = 0-8 mole%, (Al-BAG) showing haemostatic property as well as antibacterial activity.