Article
Biochemistry & Molecular Biology
Ashraf Y. Elfert, Amel Salem, Amr M. Abdelhamid, Ahmad Salama, Doaa A. Sourour, Olfat Shaker, Mofida Keshk
Summary: The expression profiles of miRNA-122, miR-483, and miR-335 were studied in the serum of HCV-related hepatocellular carcinoma (HCC) patients. miR-122 and miR-483 were upregulated in HCC patients, while miR-335 was downregulated. These miRNAs could serve as potential non-invasive early diagnostic biomarkers for HCC, with miR-483 showing the highest diagnostic accuracy and sensitivity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Mei-Ling Dong, Xu Wen, Xin He, Ji-Hua Ren, Hai-Bo Yu, Yi-Ping Qin, Zhen Yang, Min-Li Yang, Chong-Yang Zhou, Hui Zhang, Sheng-Tao Cheng, Juan Chen
Summary: The study found that DDX17 plays an important role in the replication of HBV and the metastasis of HBV-related HCC. By promoting HBV replication and transcription as well as HBx-mediated HCC metastasis, DDX17 has a promotive effect on the development of HBV and HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Guangyuan Song, Xingxin Zhu, Zefeng Xuan, Long Zhao, Haijiang Dong, Jian Chen, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Summary: In this study, we identified that GNA14 is downregulated in HCC and negatively correlated with HBV infection, vascular invasion, and prognosis. HBx regulates GNA14 through DNA methylation, affecting the Notch1 and JMJD6 pathways to inhibit tumor proliferation and metastasis. GNA14 shows potential as a biomarker and therapeutic target in HCC.
Article
Oncology
Haixia Shan, Bo Wang, Xiaodong Zhang, Hui Song, Xi Li, Yongxin Zou, Baichun Jiang, Huili Hu, Hao Dou, Changshun Shao, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong Liang, Yaoqin Gong
Summary: The study found that CUL4B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation. The results of this study are of great significance for the development of potential targets for anti-HBV therapy.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hiroaki Kanzaki, Tetsuhiro Chiba, Tatsuya Kaneko, Junjie Ao, Motoyasu Kan, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Yoh Zen, Ai Kotani, Kazuma Sekiba, Motoyuki Otsuka, Masayuki Ohtsuka, Naoya Kato
Summary: ELAVL1 protein is not only involved in the replication of hepatitis B virus, but also has an impact on the cell growth of hepatocellular carcinoma, making it a potential therapeutic target for HBV-related HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Shuang Wu, Shihai Liu, Yongxian Cao, Geng Chao, Peng Wang, Huazheng Pan
Summary: This study identifies ZC3H13 as a potential tumor suppressor gene in hepatocellular carcinoma (HCC) and reveals the miR-362-3p/miR-425-5p-ZC3H13 axis as a regulatory pathway. The expression of ZC3H13 is closely associated with the prognosis and tumor immune infiltration in HCC.
Article
Biochemistry & Molecular Biology
Ana R. Rama, Francisco Quinonero, Cristina Mesas, Consolacion Melguizo, Jose Prados
Summary: This study presents a circular RNA-based miRNA capture system for studying the role of miR-21 in lung cancer. The miR-21 circular sponge was found to inhibit the growth, colony formation, and migration of lung cancer cells, indicating the potential of this method as a tool for capturing other miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Mauro Esposito, Nicolo Gualandi, Giovanni Spirito, Federico Ansaloni, Stefano Gustincich, Remo Sanges
Summary: L1 LINEs are transposable elements that can replicate within the genome. They may have been positively selected for beneficial cellular functions, but their deregulation can lead to diseases. miRNAs and ceRNAs regulate transcript levels in somatic cells. This study found that L1s may act as ceRNAs and help interpret transcriptomic responses.
Article
Oncology
Wenbiao Chen, Jingjing Jiang, Lan Gong, Zheyue Shu, Dairong Xiang, Xujun Zhang, Kefan Bi, Hongyan Diao
Summary: The study found that Hepatitis B virus (HBV) infection promotes the proliferation and migration of hepatocellular carcinoma (HCC) cells through affecting the glycolytic bypass. By reducing the expression of MINPP1, miRNA-30b-5p plays a role in promoting tumor cell proliferation in HBV-positive HCC. Bioinformatics analysis on a large dataset showed that high expression of MINPP1 is associated with favorable survival in HBV-positive HCC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Tao Wan, Zhao Lei, Biao Tu, Tianyin Wang, Jiale Wang, Feizhou Huang
Summary: NEDD4 plays a dual role in carcinogenesis, acting as a tumor suppressor in HBV-associated HCC by degrading HBx as an E3 ubiquitin ligase, leading to better overall survival and progression-free survival in patients. High NEDD4 expression is not related to HBV exposure but inhibits proliferation, migration, and invasion in HBV-related HCC cell lines.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhuanchang Wu, Liyuan Wang, Xin Wang, Yang Sun, Haoran Li, Zhaoying Zhang, Caiyue Ren, Xiaohui Zhang, Shuangjie Li, Jinghui Lu, Leiqi Xu, Xuetian Yue, Yue Hong, Qiang Li, Haizhen Zhu, Yaoqin Gong, Chengjiang Gao, Huili Hu, Lifen Gao, Xiaohong Liang, Chunhong Ma
Summary: This study identified the cohesin/CTCF complex as a critical host restriction factor for cccDNA-driven HBV replication. The cohesin complex binds to cccDNA with the help of CTCF and reshapes the confirmation of cccDNA to prevent RNA polymerase II enrichment, resulting in reduced HBV replication. Interestingly, the HBV X protein transcriptionally reduces the expression of the structural maintenance of chromosomes complex to partially relieve the inhibitory role of the cohesin complex on HBV replication.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Clinical Neurology
Michaela Krivosova, Jana Adamcakova, Erik Kaadt, Birgitte Hviid Mumm, Dana Dvorska, Dusan Brany, Zuzana Dankova, Matus Dohal, Marek Samec, Nikola Ferencova, Ingrid Tonhajzerova, Igor Ondrejka, Igor Hrtanek, Peter Hutka, Miloslav Oppa, Juraj Mokry, Betina Elfving
Summary: This study investigated the plasma levels of vascular endothelial growth factor (VEGF) in children and adolescents with major depressive disorder (MDD) and examined the impact of antidepressant treatment on VEGF levels. The results showed that the levels of VEGF were significantly increased in depressed individuals and were decreased after a short course of antidepressant treatment. Additionally, certain microRNAs were found to be associated with the regulation of VEGF. This study supports the use of VEGF as a biomarker for MDD in children and adolescents and highlights the importance of understanding the underlying regulatory mechanisms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Genetics & Heredity
Liping Zou, Qiwen Feng, Wei Xia, Changhong Zhu
Summary: This study aimed to identify common targets of miR-223-3p, miR-122-5p, and miR-93-5p in PCOS and assess their transcript levels in PCOS rat ovaries. Transcriptome profiles of granulosa cells from PCOS patients were analyzed to identify DEGs, followed by miRNA target prediction and functional analysis. The study identified several potential genes, including JMJD1C, PLCG2, SMAD3, FOSL2, TGFB1, TRIB1, GAS7, TRIM25, NFYA, and CALCRL, which may play a role in the development of PCOS. These findings contribute to the identification of potential biomarkers for the prevention and treatment of PCOS in the future.
FRONTIERS IN GENETICS
(2023)
Article
Genetics & Heredity
Dalia A. Gaber, Olfat Shaker, Alaa Tarek Younis, Mohamed El-Kassas
Summary: In this study, the expression levels of Lnc HULC and miR-122 genes were tested in the serum of patients with chronic HCV and HCC. The results showed that miR-122 is a prognostic tool for HCC in patients with chronic HCV, while HULC can be used as an early diagnostic tool for HCC.