Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

(2017) Y. Yin et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Inflammasomes as polyvalent cell death platforms

(2016) Nathalia M. de Vasconcelos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial CellsNovelty and Significance

(2016) Hang Xi et al.   CIRCULATION RESEARCH

Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair

(2016) Cong-xin Huang   Frontiers in Bioscience-Landmark

Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets—“Sand Out and Gold Stays”

(2016) Ying Shao et al.   Journal of Cardiovascular Translational Research

Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery

(2016) Lucas M. Ferrer et al.   Journal of Cardiovascular Translational Research

Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

(2016) Xin Wang et al.   Journal of Cardiovascular Translational Research

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy

(2015) Ya-Feng Li et al.   Journal of Hematology & Oncology

Exosome-mediated inflammasome signaling after central nervous system injury

(2015) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF NEUROCHEMISTRY

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury

(2015) Srabani Mitra et al.   PLoS One

IFI16: At the interphase between innate DNA sensing and genome regulation

(2014) Martin R. Jakobsen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function

(2014) Ying Shao et al.   Journal of Hematology & Oncology

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate

(2014) A Aries et al.   Cell Death & Disease

COMPARTMENTS: unification and visualization of protein subcellular localization evidence

(2014) J. X. Binder et al.   Database-The Journal of Biological Databases and Curation

Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets

(2013) Mingjun Wang et al.   BIOINFORMATICS

Inflammasomes: sensors of metabolic stresses for vascular inflammation 

(2013) Xiao-feng Yang   Frontiers in Bioscience-Landmark

Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells

(2013) M. A. Ansari et al.   JOURNAL OF VIROLOGY

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

(2012) Gloria Lopez-Castejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

(2012) Janna A. van Diepen et al.   JOURNAL OF LIPID RESEARCH

Caspase-1: is IL-1 just the tip of the ICEberg?

(2012) A Denes et al.   Cell Death & Disease

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome

(2011) Katherine Labbé et al.   IMMUNITY

Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1 -Rich Microparticles

(2011) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Inflammatory Stimuli Regulate Caspase Substrate Profiles

(2010) Nicholas J. Agard et al.   MOLECULAR & CELLULAR PROTEOMICS

Caspase-1 recognizes extended cleavage sites in its natural substrates

(2009) Jerry Shen et al.   ATHEROSCLEROSIS

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

The Inflammasomes

(2009) Mohamed Lamkanfi et al.   PLoS Pathogens

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

Caspase-mediated Degradation of PPARγ Proteins in Adipocytes

(2008) Fang He et al.   Obesity