New fluorinated diarylureas linked to pyrrolo[2,3-d]pyrimidine scaffold as VEGFR-2 inhibitors: Molecular docking and biological evaluation

New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation

(2022) Abdallah E Abdallah et al.   Drug Design Development and Therapy

Diarylureas as Antitumor Agents

(2021) Alessia Catalano et al.   Applied Sciences-Basel

Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF-κB and VEGFR2 signaling

(2021) Xiaohe Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

(2020) Heba T. Abdel-Mohsen et al.   MOLECULES

Structural, functional, and stability change predictions in human telomerase upon specific point mutations

(2019) U. Kalathiya et al.   Scientific Reports

Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors

(2019) Heba T. Abdel-Mohsen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular insight of regorafenib treatment for colorectal cancer

(2019) Hiroyuki Arai et al.   CANCER TREATMENT REVIEWS

The Significance of Halogen Bonding in Ligand–Receptor Interactions: The Lesson Learned from Molecular Dynamic Simulations of the D4 Receptor

(2019) Rafał Kurczab et al.   MOLECULES

Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling

(2018) Mai Adel et al.   BIOORGANIC CHEMISTRY

Research progress of diphenyl urea derivatives As anticancer agents And Synthetic methodologies

(2018) Yi-Cong Wu et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Receptor tyrosine kinase inhibition by regorafenib/sorafenib inhibits growth and invasion of meningioma cells

(2017) Marcus Tuchen et al.   EUROPEAN JOURNAL OF CANCER

Vatalanib, a tyrosine kinase inhibitor, decreases hepatic fibrosis and sinusoidal capillarization in CCl4-induced fibrotic mice

(2017) Ling-Jian Kong et al.   Molecular Medicine Reports

Synthesis, characterization and anti cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

(2017) Deepak Chowrasia et al.   Arabian Journal of Chemistry

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Discovery of Novel Dengue NS2B/NS3 Protease Inhibitors Using Pharmacophore Modeling and Molecular Docking Based Virtual Screening of the ZINC Database

(2016) Usman Ali Ashfaq et al.   International Journal of Pharmacology

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

(2016) Marwa A. Aziz et al.   Scientific Reports

Fibroblast growth factor receptor 1 gene amplification in gastric adenocarcinoma

(2015) Manuel H. Schäfer et al.   HUMAN PATHOLOGY

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

(2014) Zheng Zhao et al.   ACS Chemical Biology

Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent®) a VEGFR2/PDGFRβ/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial

(2014) Vivek Subbiah et al.   Journal of Hematology & Oncology

Organic Fluorine as a Hydrogen-Bond Acceptor: Recent Examples and Applications

(2014) Jean-François Paquin et al.   SYNTHESIS-STUTTGART

Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization

(2014) Kiyoshi Okamoto et al.   ACS Medicinal Chemistry Letters

Expression and prognostic value of VEGFR-2, PDGFR-β, and c-Met in advanced hepatocellular carcinoma

(2013) Jie Sheng Chu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The graphical representation of ADME-related molecule properties for medicinal chemists

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

(2010) Scott M. Wilhelm et al.   INTERNATIONAL JOURNAL OF CANCER

Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations

(2010) Pengyuan Wang et al.   TETRAHEDRON LETTERS

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

FiberDock: Flexible induced-fit backbone refinement in molecular docking

(2009) Efrat Mashiach et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor†

(2008) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2

(2008) Qing-Qing Xie et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one: new trifluoromethyl building block

(2008) Olugbeminiyi O. Fadeyi et al.   TETRAHEDRON LETTERS