Toxic Misfolded Transthyretin Oligomers with Different Molecular Conformations Formed through Distinct Oligomerization Pathways
出版年份 2022 全文链接
标题
Toxic Misfolded Transthyretin Oligomers with Different Molecular Conformations Formed through Distinct Oligomerization Pathways
作者
关键词
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出版物
BIOCHEMISTRY
Volume 61, Issue 21, Pages 2358-2365
出版商
American Chemical Society (ACS)
发表日期
2022-10-11
DOI
10.1021/acs.biochem.2c00390
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin
- (2021) James A. Ferguson et al. BIOCHEMISTRY
- A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction
- (2021) Xin Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases
- (2021) Klara Kulenkampff et al. Nature Reviews Chemistry
- The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
- (2021) Roberta Cascella et al. Nature Communications
- Structural basis for transthyretin amyloid formation in vitreous body of the eye
- (2021) Irina Iakovleva et al. Nature Communications
- Cardiac Amyloidosis: Overlooked, Underappreciated, and Treatable
- (2020) Jonah Rubin et al. Annual Review of Medicine
- Emerging therapies in transthyretin amyloidosis – a new wave of hope after years of stagnancy?
- (2020) Maximilian L. Müller et al. EUROPEAN JOURNAL OF HEART FAILURE
- Structural Characterization of Cardiac Ex Vivo Transthyretin Amyloid: Insight into the Transthyretin Misfolding Pathway In Vivo
- (2020) Anvesh K. R. Dasari et al. BIOCHEMISTRY
- Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway
- (2020) Anvesh K. R. Dasari et al. BIOCHEMISTRY
- Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils
- (2020) Sara Raimondi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diagnosis and Screening of Patients with Hereditary Transthyretin Amyloidosis (hATTR): Current Strategies and Guidelines
- (2020) MD Benson et al. Therapeutics and Clinical Risk Management
- Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity
- (2020) Ana Frangolho et al. MOLECULES
- Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
- (2019) Anvesh K. R. Dasari et al. Scientific Reports
- The toxicity of misfolded protein oligomers is independent of their secondary structure
- (2019) Mirella Vivoli Vega et al. ACS Chemical Biology
- Cardiac amyloidosis: An underdiagnosed/underappreciated disease
- (2019) Antonis S. Manolis et al. European Journal of Internal Medicine
- Transthyretin Amyloid Cardiomyopathy
- (2019) Frederick L. Ruberg et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis
- (2019) Matthias Schmidt et al. Nature Communications
- TTR (Transthyretin) Stabilizers Are Associated With Improved Survival in Patients With TTR Cardiac Amyloidosis
- (2018) Hannah Rosenblum et al. Circulation-Heart Failure
- Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease
- (2018) Elena S. Klimtchuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
- (2017) Giuliana Fusco et al. SCIENCE
- Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients
- (2017) Joseph D. Schonhoft et al. Science Translational Medicine
- Solid-State NMR Studies Reveal Native-like β-Sheet Structures in Transthyretin Amyloid
- (2016) Kwang Hun Lim et al. BIOCHEMISTRY
- A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
- (2015) J. Marcoux et al. EMBO Molecular Medicine
- Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
- (2015) Serene W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity
- (2014) Benedetta Mannini et al. ACS Chemical Biology
- NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
- (2014) Woonghee Lee et al. BIOINFORMATICS
- Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis
- (2013) Elisabet Ihse et al. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
- Protein Misfolded Oligomers: Experimental Approaches, Mechanism of Formation, and Structure-Toxicity Relationships
- (2012) Francesco Bemporad et al. CHEMISTRY & BIOLOGY
- THAOS – The Transthyretin Amyloidosis Outcomes Survey: initial report on clinical manifestations in patients with hereditary and wild-type transthyretin amyloidosis
- (2012) Teresa Coelho et al. CURRENT MEDICAL RESEARCH AND OPINION
- Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity
- (2012) Marcus Fändrich JOURNAL OF MOLECULAR BIOLOGY
- Structural features and cytotoxicity of amyloid oligomers: Implications in Alzheimer's disease and other diseases with amyloid deposits
- (2012) Massimo Stefani PROGRESS IN NEUROBIOLOGY
- Atomic View of a Toxic Amyloid Small Oligomer
- (2012) Arthur Laganowsky et al. SCIENCE
- Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation
- (2010) V. L. Anderson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transthyretin: the servant of many masters
- (2009) Joel N. Buxbaum et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Structural Classification of Toxic Amyloid Oligomers
- (2008) Charles G. Glabe JOURNAL OF BIOLOGICAL CHEMISTRY
- Folding versus aggregation: Polypeptide conformations on competing pathways
- (2007) Thomas R. Jahn et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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