Discovery of EMD37, a 1,2,4-oxadiazole derivative, as a novel endoplasmic reticulum stress inducer with potent anticancer activity

Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors

(2022) Eric Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preclinical activity of fluvastatin‐loaded self‐nanoemulsifying delivery system against breast cancer models: Emphasis on apoptosis

(2022) Hanan Elimam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Insights into the design of inhibitors of the EGFR family with anticancer activity overcoming resistance: A case of optimizing thieno[2,3-d]pyrimidine-based EGFR inhibitors

(2022) Sandra N. Milik et al.   JOURNAL OF MOLECULAR STRUCTURE

The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer

(2021) Soma Samanta et al.   CANCER RESEARCH

Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC)

(2021) Yong Chen et al.   BIOORGANIC CHEMISTRY

Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer

(2021) Eman M.E. Dokla et al.   BIOORGANIC CHEMISTRY

Endoplasmic Reticulum Stress Signaling in Cancer Cells

(2020) Scott A. Oakes   AMERICAN JOURNAL OF PATHOLOGY

Targeting YAP degradation by a novel 1,2,4-oxadiazole derivative via restoration of the function of the Hippo pathway

(2020) Eman M. E. Dokla et al.   ACS Medicinal Chemistry Letters

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

(2020) Xin Li et al.   Journal of Hematology & Oncology

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition

(2019) Amal Kamal Abdel-Aziz et al.   HAEMATOLOGICA

Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside

(2019) Amal Kamal Abdel-Aziz et al.   EUROPEAN JOURNAL OF CANCER

1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC

(2019) Eman M.E. Dokla et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A 5′ AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma

(2018) Jing-Ru Weng et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine

(2018) Mahendra Seervi et al.   BIOMEDICINE & PHARMACOTHERAPY

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3- d ]pyrimidine-based dual EGFR/HER2 inhibitors

(2018) Sandra N. Milik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences

(2018) Anqi Zhu et al.   BIOINFORMATICS

How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors

(2017) Sandra N. Milik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib

(2017) Amal Kamal Abdel-Aziz et al.   Frontiers in Pharmacology

Cabozantinib in metastatic renal cell carcinoma: latest findings and clinical potential

(2017) Melissa Bersanelli et al.   Therapeutic Advances in Medical Oncology

Dual modulation of MCL-1 and mTOR determines the response to sunitinib

(2016) Mohamed Elgendy et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

(2016) Paola Vianello et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

(2016) Marwa A. Aziz et al.   Scientific Reports

Integrated Systems for NGS Data Management and Analysis: Open Issues and Available Solutions

(2016) Valerio Bianchi et al.   Frontiers in Genetics

Lenvatinib – A multikinase inhibitor for radioiodine-refractory differentiated thyroid cancer

(2016) Yvonne Hewett et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Identification of known drugs targeting the endoplasmic reticulum stress response

(2015) Kun Bi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

DSigDB: drug signatures database for gene set analysis: Fig. 1.

(2015) Minjae Yoo et al.   BIOINFORMATICS

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Modulation of Imatinib Cytotoxicity by Selenite in HCT116 Colorectal Cancer Cells

(2014) Amal Kamal Abdel-Aziz et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries

(2014) Amal Kamal Abdel-Aziz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma

(2013) Peikai Chen et al.   BMC BIOINFORMATICS

ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells

(2013) Duo-te Cai et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The EGFR T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor

(2012) Y. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines

(2010) S. L. Holbeck et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Detection of BCR-ABL gene mutations in Philadelphia chromosome positive leukemia patients resistant to STI-571 cancer therapy

(2008) Ju-Huei Chien et al.   LEUKEMIA RESEARCH

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA