Tangeretin prevents cognitive deficit in delirium through activating RORα/γ-E4BP4 axis in mice

E4BP4 Coordinates Circadian Control of Cognition in Delirium

(2022) Min Chen et al.   Advanced Science

Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

(2021) Tianpeng Zhang et al.   Nature Communications

Identification of rhythmic human CYPs and their circadian regulators using synchronized hepatoma cells

(2020) Min Chen et al.   XENOBIOTICA

Neuroprotective and Anti-inflammatory Effect of Tangeretin Against Cerebral Ischemia-Reperfusion Injury in Rats

(2020) Tiansong Yang et al.   INFLAMMATION

Roles of GABAA receptor α5 subunit on locomotion and working memory in transient forebrain ischemia in mice

(2020) Dong Hyun Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Small Molecule Modulators of the Circadian Molecular Clock With Implications for Neuropsychiatric Diseases

(2019) Hyo Kyeong Cha et al.   Frontiers in Molecular Neuroscience

REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output

(2019) Ryosuke Ikeda et al.   Scientific Reports

Delirium

(2019) Robyn P. Thom et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-containing Monooxygenase 5 in Mouse Liver

(2019) Min Chen et al.   DRUG METABOLISM AND DISPOSITION

Circadian clock-controlled drug metabolism and transport

(2019) Mengjing Zhao et al.   XENOBIOTICA

The polymethoxylated flavone, Tangeretin improves cognitive memory in rats experiencing a single episode of prolonged post-traumatic stress

(2018) Bombi Lee et al.   Animal Cells and Systems

The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium*

(2018) Jennifer Gile et al.   CRITICAL CARE MEDICINE

Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway

(2018) Mu Zhang et al.   Theranostics

Incidence and Prevalence of Delirium Subtypes in an Adult ICU

(2018) Karla D. Krewulak et al.   CRITICAL CARE MEDICINE

Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis

(2017) Jun Dai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tangeretin ameliorates renal failure via regulating oxidative stress, NF-κB–TNF-α/iNOS signalling and improves memory and cognitive deficits in 5/6 nephrectomized rats

(2017) Jing Wu et al.   INFLAMMOPHARMACOLOGY

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

ROR nuclear receptors: structures, related diseases and drug discovery

(2014) Yan Zhang et al.   ACTA PHARMACOLOGICA SINICA

Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture

(2014) Xiao Yu et al.   CURRENT BIOLOGY

Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats

(2014) Ramalingam Sundaram et al.   PHYTOMEDICINE

The Impact of Acute Brain Dysfunction in the Outcomes of Mechanically Ventilated Cancer Patients

(2014) Isabel C. T. Almeida et al.   PLoS One

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

(2014) Subhashis Banerjee et al.   Nature Communications

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

(2013) Mi Ra Chang et al.   Arthritis & Rheumatology

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Small molecule modifiers of circadian clocks

(2012) Zheng Chen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

(2010) Yongjun Wang et al.   ACS Chemical Biology

The role of circadian timing system on drug metabolism and detoxification

(2010) Frédéric Gachon et al.   Expert Opinion on Drug Metabolism & Toxicology

Delirium in Elderly Patients and the Risk of Postdischarge Mortality, Institutionalization, and Dementia

(2010) Joost Witlox et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacokinetic Study of Nobiletin and Tangeretin in Rat Serum by High-Performance Liquid Chromatography−Electrospray Ionization−Mass Spectrometry

(2010) John A. Manthey et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Plastic modifications induced by object recognition memory processing

(2010) J. R. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and A  Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2008) H. Onozuka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

(2008) Andrew C. Liu et al.   PLoS Genetics