Review
Biotechnology & Applied Microbiology
Marlene Pluess, Silvia Piantoni, Bjoern Tampe, Alfred H. J. Kim, Peter Korsten
Summary: Advances in the treatment and management of systemic lupus erythematosus have improved patient outcomes, but lupus nephritis remains a major complication. Belimumab has been shown to be superior as an add-on therapy for lupus nephritis, and personalized treatment options are expected with the development of new therapeutic agents.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Masahiro Nakano, Yukiko Iwasaki, Keishi Fujio
Summary: Studies on SLE have identified several disease-relevant signatures, including the IFN signature, myeloid lineage/neutrophil and plasma cell signatures, and the exhaustion signature in CD8(+) T cells, which are correlated with disease activity, nephritis, and complications of pregnancy. Further research is needed to identify treatment targets and patient stratification in SLE, as well as to understand the molecular heterogeneity and distinct subpopulations involved in the pathogenesis of SLE.
INFLAMMATION AND REGENERATION
(2021)
Article
Immunology
Xinxia Lu, Liangao Wang, Meng Wang, Yuejin Li, Qinqin Zhao, Yanjun Shi, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li
Summary: This study evaluated the performance of IgG N-glycosylation in diagnosing lupus nephritis (LN) in female systemic lupus erythematosus (SLE) patients. The results showed that specific glycans and anemia were associated with LN. These IgG N-glycans can serve as potential biomarkers to differentiate LN among SLE patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Antonis Fanouriakis, Myrto Kostopoulou, Jeanette Andersen, Martin Aringer, Laurent Arnaud, Sang-Cheol Bae, John Boletis, Ian N. Bruce, Ricard Cervera, Andrea Doria, Thomas Doerner, Richard A. Furie, Dafna D. Gladman, Frederic A. Houssiau, Luis Sousa Ines, David Jayne, Marios Kouloumas, Laszlo Kovacs, Chi Chiu Mok, Eric F. Morand, Gabriella Moroni, Marta Mosca, Johanna Mucke, Chetan B. Mukhtyar, Gyoergy Nagy, Sandra Navarra, Ioannis Parodis, Jose M. Pego-Reigosa, Michelle Petri, Bernardo A. Pons-Estel, Matthias Schneider, Josef S. Smolen, Elisabet Svenungsson, Yoshiya Tanaka, Maria G. Tektonidou, Y. K. Onno Teng, Angela Tincani, Edward M. Vital, Ronald F. van Vollenhoven, Chris Wincup, George Bertsias, Dimitrios T. Boumpas
Summary: The EULAR recommendations for the management of systemic lupus erythematosus (SLE) have been updated based on emerging new evidence. The updated recommendations provide consensus guidance on the use of various medications and treatment strategies to control the disease, as well as recommendations for assessing treatment response and tapering therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Microbiology
Ping Yang, Rui Xu, Fei Chen, Shanshan Chen, Adeel Khan, Liang Li, Xiaoshan Zhang, Yanbo Wang, Zhipeng Xu, Han Shen
Summary: This study investigates the gut fungal dysbiosis and ecology in patients with SLE and demonstrates the applicability of fungal species as diagnostic tools for SLE. It suggests that the interaction between the gut fungal mycobiome and the host may contribute to the pathogenesis of the disease.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Robert Silver, Sabrina Craigo, Flint Porter, Sarah S. Osmundson, Jeffrey A. Kuller, Mary E. Norton
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by relapses and remission. It can affect various organs, with the kidneys, joints, and skin being commonly affected. Immunologic abnormalities, such as the production of antinuclear antibodies, are also characteristic of the disease. This document provides recommendations for the treatment and management of SLE during pregnancy, including the use of medications and the prevention of complications.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Urology & Nephrology
Momin H. Alkhatib, Sam Kant, Steven Menez, Laila Lakhani, Christopher John Sperati, Derek M. Fine, Lois J. Arend, Mohamed G. Atta
Summary: This study compared the clinical and prognostic characteristics of thrombotic microangiopathy (TMA) with class IV lupus nephritis in SLE patients. TMA patients showed significant abnormalities in certain laboratory markers and had a worse prognosis.
JOURNAL OF NEPHROLOGY
(2021)
Article
Environmental Sciences
Heming Bai, Lei Jiang, Ting Li, Chong Liu, Xiaoxia Zuo, Yi Liu, Shaoxian Hu, Linyun Sun, Miaojia Zhang, Jin Lin, Weiguo Xiao, Qingwen Wang, Dongbao Zhao, Huaxiang Wu, Xiaodan Kong, Wenkang Gao, Wanxin Hou, Myeongsu Seong, Yuanpeng Zhang, Fangfang Chen, Sheng Chen, Xin Wu, Chunde Bao, Li Wang, Huji Xu
Summary: The study found that air pollutants PM2.5 and NO2 may be risk factors for lupus nephritis (LN), while short-term exposure to CO and O-3 does not generally have an association with LN. Furthermore, negative associations of LN with SO2 were observed for the entire region and east China.
ENVIRONMENTAL RESEARCH
(2021)
Article
Rheumatology
Yoshiya Tanaka
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease that causes damage to multiple organs. Current treatments mainly involve glucocorticoids and immunosuppressants, but the development of molecular target drugs with minimal side effects is desired. Research is focused on finding new approaches such as targeted therapies and drugs that modulate the innate and adaptive immune systems.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Review
Cell Biology
Chenghui Zheng, Lin Xie, Haihong Qin, Xiao Liu, Xi Chen, Fan Lv, Li Wang, Xiaohua Zhu, Jinhua Xu
Summary: Extracellular vesicles (EVs) are small vesicles actively secreted by most cell types, which can carry various substances and play important roles in immune modulation and the pathogenesis of autoimmune diseases. This review summarizes the recent research on EVs and discusses their applications in the pathogenesis, diagnosis, and treatment of systemic lupus erythematosus (SLE).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Orlando Vieira Gomes, Leonardo Fernandes e Santana, Rita Marina Soares de Castro Duarte, Mateus de Sousa Rodrigues, Jandir Mendonca Nicacio, Dyego Jose de Araujo Brito, Monique Pereira Rego Muniz, Natalino Salgado-Filho, Precil Diego Miranda de Menezes Neves, Gyl Eanes Barros Silva
Summary: Lupus nephritis is a serious manifestation of systemic lupus erythematosus, primarily affecting the glomerulus, but can also present as an isolated tubular disease. Early diagnosis and treatment are crucial for patient outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Pondtip Jongvilaikasem, Pornpimol Rianthavorn
Summary: Patients with childhood-onset systemic lupus erythematosus are at risk of becoming short adults, with independent risk factors including male sex, short stature at diagnosis, low body weight at final height, and cumulative corticosteroid dose. Adequate nutrition and corticosteroid minimization should be emphasized in patients at high risk for short final height.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
In Hee Lee, Seong Cho, Dong Jik Ahn, Min-Kyung Kim
Summary: SLE can present with hyponatremia-associated rhabdomyolysis as the initial manifestation, which is rare. Prompt fluid therapy and timely administration of immunosuppressive agents can significantly alleviate disease activity and improve clinical outcomes in such cases.