A framework for establishing scientific confidence in new approach methodologies

Integration of toxicodynamic and toxicokinetic new approach methods into a weight-of-evidence analysis for pesticide developmental neurotoxicity assessment: A case-study with DL- and L-glufosinate

(2022) Sarah Dobreniecki et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies

(2022) Agnes L Karmaus et al.   TOXICOLOGICAL SCIENCES

Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment

(2021) Federica Madia et al.   ARCHIVES OF TOXICOLOGY

Human-relevant approaches to assess eye corrosion/irritation potential of agrochemical formulations

(2021) Amy J. Clippinger et al.   Cutaneous and Ocular Toxicology

Use of Cause-and-Effect Analysis to Optimize the Reliability of In Vitro Inhalation Toxicity Measurements Using an Air–Liquid Interface

(2021) Elijah J. Petersen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Analysis of variability in the rabbit skin irritation assay

(2021) John P. Rooney et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

(2020) Kamel Mansouri et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

An evaluation framework for new approach methodologies (NAMs) for human health safety assessment

(2020) Stanley T. Parish et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

High-Throughput Screening to Identify Chemical Cardiotoxic Potential

(2020) Shagun Krishna et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Animal to human translation: a systematic scoping review of reported concordance rates

(2019) Cathalijn H. C. Leenaars et al.   Journal of Translational Medicine

Regarding the references for reference chemicals of alternative methods

(2019) S.N. Kolle et al.   TOXICOLOGY IN VITRO

Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database

(2018) Sebastian Hoffmann et al.   CRITICAL REVIEWS IN TOXICOLOGY

Non-animal methods to predict skin sensitization (II): an assessment of defined approaches

(2018) Nicole C. Kleinstreuer et al.   CRITICAL REVIEWS IN TOXICOLOGY

Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods

(2018) Anna Bal-Price et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report

(2018) Amy J. Clippinger et al.   TOXICOLOGY IN VITRO

Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies

(2018) A.H. Piersma et al.   TOXICOLOGY IN VITRO

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

(2018) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Development of a curated Hershberger database

(2018) P. Browne et al.   REPRODUCTIVE TOXICOLOGY

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

(2018) Arun V. Kolanjiyil et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals

(2018) Helen Prior et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular™ ET-50 method to classify according to UN GHS

(2017) Susanne N. Kolle et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Steps towards the international regulatory acceptance of non-animal methodology in safety assessment

(2017) Fiona Sewell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Uncertainties of testing methods: What do we (want to) know about carcinogenicity?

(2017) Martin Paparella   ALTEX-Alternatives to Animal Experimentation

Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD)

(2016) João Barroso et al.   ARCHIVES OF TOXICOLOGY

Development and Validation of a Computational Model for Androgen Receptor Activity

(2016) Nicole C. Kleinstreuer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

(2016) Kamel Mansouri et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches

(2016) Coralie Dumont et al.   TOXICOLOGY IN VITRO

Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

(2016) Thomas Luechtefeld   ALTEX-Alternatives to Animal Experimentation

First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

The Flaws and Human Harms of Animal Experimentation

(2015) AYSHA AKHTAR   CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS

A Curated Database of Rodent Uterotrophic Bioactivity

(2015) Nicole C. Kleinstreuer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

LLNA variability: An essential ingredient for a comprehensive assessment of non-animal skin sensitization test methods and strategies

(2015) Sebastian Hoffmann   ALTEX-Alternatives to Animal Experimentation

Food for Thought … Mechanistic Validation

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Developmental neurotoxicity – Challenges in the 21st Century and In Vitro Opportunities

(2014) Lena Smirnova   ALTEX-Alternatives to Animal Experimentation

Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

(2013) Marcel Leist et al.   ARCHIVES OF TOXICOLOGY

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods

(2013) Els Adriaens et al.   ARCHIVES OF TOXICOLOGY

Developmental neurotoxicity guideline study: Issues with methodology, evaluation and regulation*

(2012) Ryozo Tsuji et al.   CONGENITAL ANOMALIES

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Why animal studies are often poor predictors of human reactions to exposure

(2009) Michael B Bracken   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE