Fabrication of magnetic Au/Fe3O4/MIL-101(Cr) (AF-MIL) as sensitive surface-enhanced Raman spectroscopy (SERS) platform for trace detection of antibiotics residue

Fabrication of a magnetic substrate based on metal-organic frameworks (MOFs) with high sensitivity and stability for surface-enhanced Raman scattering (SERS) analysis were reported in this paper. MIL-101(Cr) nanoparticle prepared via a traditional hydrothermal reaction, which was combined with Fe3O4 to synthesize the Fe3O4/MIL-101(Cr) composites. Then, the concentration of chloroauric acid and the time of reduction reaction were adjusted to acquire the optimal Au/Fe3O4/MIL-101(Cr) (AF-MIL) SERS substrate. The detection ability of the substrate can down to 10(-8) mol/L for Rhodamine 6G (R6G) as probe molecule, and the relative standard deviation (RSD) is only about 4.48 %, which indicates that it possesses wonderful SERS performance and uniformity. Finally, the as-synthesized substrate has been adopted to test the trace level sulfapyridine, with its desirable detection ability can down to 10(-6) mol/L. Such desirable SERS substrate with facile and effective operation holds great promise in the fast sensitive detection of the antibiotic residue and some other pollutants in environment.

Automated summary

This paper reports the fabrication of a magnetic substrate based on metal-organic frameworks (MOFs) for surface-enhanced Raman scattering (SERS) analysis with high sensitivity and stability. The substrate exhibited excellent SERS performance and uniformity, allowing for the detection of trace levels of Rhodamine 6G and sulfapyridine.