4.5 Article

Resting-state EEG power and coherence vary between migraine phases

期刊

JOURNAL OF HEADACHE AND PAIN
卷 17, 期 -, 页码 -

出版社

BMC
DOI: 10.1186/s10194-016-0697-7

关键词

Migraine without aura; Resting-state; EEG; Power; Isolated effective coherence

资金

  1. Computational Intelligence and Brain Computer Interface (CI&BCI) Centre, University of Technology Sydney
  2. Australian Research Council (ARC) [DP150101645]
  3. UST-UCSD International Center of Excellence in Advanced Bioengineering - Taiwan National Science Council I-RiCE Program [MOST-103-2911-I-009-101]
  4. Aiming for the Top University Plan of National Chiao-Tung University - Ministry of Education of Taiwan [104 W963]
  5. National Science Council of Taiwan [MOST 103-2321-B-010-017]
  6. Army Research Laboratory [W911NF-10-2-0022]
  7. Ministry of Science and Technology of Taiwan [104-2314-B-010-015-MY2, 103-2321-B-010-017]
  8. Taipei-Veterans General Hospital [VGHUST104-G7-1-1, V104C-082, V104E9-001]
  9. Ministry of Science and Technology [MOST 103-2911-I-008-001]
  10. Academia Sinica [IBMS-CRC103-P04]
  11. Brain Research Center, National Yang-Ming University, Ministry of Health and Welfare [MOHW104-TDU-B-211-113-003]
  12. Ministry of Education, Aim for the Top University Plan

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Background: Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal). It is of great interest whether resting-state electroencephalography (EEG) is differentiable between these phases. Methods: We compared resting-state EEG energy intensity and effective connectivity in different migraine phases using EEG power and coherence analyses in patients with migraine without aura as compared with healthy controls (HCs). EEG power and isolated effective coherence of delta (1-3.5 Hz), theta (4-7.5 Hz), alpha (8-12.5 Hz), and beta (13-30 Hz) bands were calculated in the frontal, central, temporal, parietal, and occipital regions. Results: Fifty patients with episodic migraine (1-5 headache days/month) and 20 HCs completed the study. Patients were classified into inter-ictal, pre-ictal, ictal, and post-ictal phases (n = 22, 12, 8, 8, respectively), using 36-h criteria. Compared to HCs, inter-ictal and ictal patients, but not pre- or post-ictal patients, had lower EEG power and coherence, except for a higher effective connectivity in fronto-occipital network in inter-ictal patients (p<.05). Compared to data obtained from the inter-ictal group, EEG power and coherence were increased in the pre-ictal group, with the exception of a lower effective connectivity in fronto-occipital network (p<.05). Inter-ictal and ictal patients had decreased EEG power and coherence relative to HCs, which were normalized in the pre-ictal or post-ictal groups. Conclusion: Resting-state EEG power density and effective connectivity differ between migraine phases and provide an insight into the complex neurophysiology of migraine.

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