Detection of Cancer Marker Flap Endonuclease 1 Using One-Pot Transcription-Powered Clustered Regularly Interspaced Short Palindromic Repeat/Cas12a Signal Expansion

Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools (Review)

(2022) Julija Dronina et al.   JOURNAL OF NANOBIOTECHNOLOGY

Signal-Amplified Detection of the Tumor Biomarker FEN1 Based on Cleavage-Induced Ligation of a Dumbbell DNA Probe and Rolling Circle Amplification

(2021) Bingzhi Li et al.   ANALYTICAL CHEMISTRY

CRISPR‐Cas12a System for Biosensing and Gene Regulation

(2021) Yuyan Shi et al.   Chemistry-An Asian Journal

FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ERα/cyclin D1/Rb axis

(2021) Lu Xu et al.   Annals of Translational Medicine

Dual-Mode FEN1 Activity Detection Based on Nt.BstNBI-Induced Tandem Signal Amplification

(2021) Haitang Yang et al.   ANALYTICAL CHEMISTRY

An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells

(2021) Bingzhi Li et al.   ANALYTICA CHIMICA ACTA

A universal CRISPR/Cas12a nucleic acid sensing platform based on proximity extension and transcription-unleashed self-supply crRNA

(2021) Guozhen Tian et al.   ANALYTICA CHIMICA ACTA

Targeting FEN1 Suppresses the Proliferation of Chronic Myeloid Leukemia Cells Through Regulating Alternative End-Joining Pathways

(2021) Yalin Zhu et al.   DNA AND CELL BIOLOGY

Exponential amplification reaction-based fluorescent sensor for the sensitive detection of tumor biomarker flap endonuclease 1

(2021) Bin Zhou et al.   SENSORS AND ACTUATORS B-CHEMICAL

A magnetic separation-assisted cascade hybridization chain reaction amplification strategy for sensitive detection of flap endonuclease 1

(2021) Liyan Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Advances and insights in the diagnosis of viral infections

(2021) Julija Dronina et al.   JOURNAL OF NANOBIOTECHNOLOGY

Graphene Quantum Dot-Based Nanocomposites for Diagnosing Cancer Biomarker APE1 in Living Cells

(2020) Hao Zhang et al.   ACS Applied Materials & Interfaces

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

(2020) Yingying Zhang et al.   DISEASE MARKERS

New CRISPR-Derived microRNA Sensing Mechanism Based on Cas12a Self-Powered and Rolling Circle Transcription-Unleashed Real-Time crRNA Recruiting

(2020) Gaoting Wang et al.   ANALYTICAL CHEMISTRY

Applying CRISPR-Cas12a as a Signal Amplifier to Construct Biosensors for Non-DNA Targets in Ultralow Concentrations

(2020) Junjie Li et al.   ACS Sensors

CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point‐of‐Care Diagnosis

(2020) Yifan Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flap endonuclease 1 (FEN1) as a novel diagnostic and prognostic biomarker for gastric cancer

(2020) Enfa Zhao et al.   Clinics and Research in Hepatology and Gastroenterology

The application of DNA polymerases and Cas9 as representative of DNA-modifying enzymes group in DNA sensor design (review)

(2020) Julija Dronina et al.   BIOSENSORS & BIOELECTRONICS

Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets

(2019) Ying Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non–Small-Cell Lung Cancer

(2018) Keqiang Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

(2018) Shi-Yuan Li et al.   CELL RESEARCH

Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression

(2018) Jiao Zou et al.   Oncotarget

Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems

(2018) Hao Zhang et al.   NANO LETTERS

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

(2013) Derek M. van Pel et al.   PLoS Genetics

FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells

(2010) K. Asagoshi et al.   MOLECULAR CANCER RESEARCH