Article
Surgery
Jasper Callemeyn, Heleen Ameye, Evelyne Lerut, Aleksandar Senev, Maarten Coemans, Elisabet Van Loon, Ben Sprangers, Vicky Van Sandt, Maud Rabeyrin, Valerie Dubois, Olivier Thaunat, Dirk Kuypers, Marie-Paule Emonds, Maarten Naesens
Summary: The study evaluated the changes in the Banff classification for antibody-mediated rejection (ABMR) and their impact on transplant outcomes and case numbers, finding an increase in cases from Banff'01 to Banff'13 and variable outcomes for reclassified sABMR in Banff'17. The clinical and histological heterogeneity of ABMR is inadequately represented in a binary classification system.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Philip F. Halloran, Georg A. Bohmig, Jonathan S. Bromberg, Klemens Budde, Gaurav Gupta, Gunilla Einecke, Farsad Eskandary, Katelynn Madill-Thomsen, Jeff Reeve
Summary: The study found that certain injury elements in kidney transplant are selective for specific pathologic mechanisms, with Dimension 3 being a newly discovered dimension involving genes related to epithelial polarity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Tahm Spitznagel, Laurenz S. S. Matter, Yves L. L. Kaufmann, Jakob Nilsson, Seraina von Moos, Thomas Schachtner
Summary: HLA-derived epitope-mismatches can help predict histopathological changes of immune-related injury in kidney transplant recipients from the first indication biopsy to the follow-up biopsy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Kaneyasu Nakagawa, Akihiro Tsuchimoto, Kenji Ueki, Yuta Matsukuma, Yasuhiro Okabe, Kosuke Masutani, Kohei Unagami, Yoichi Kakuta, Masayoshi Okumi, Masafumi Nakamura, Toshiaki Nakano, Kazunari Tanabe, Takanari Kitazono
Summary: The diagnostic criteria for CA-TCMR were revised in the Banff 2017 consensus, and showed substantial agreement among diagnosticians. Factors determining CA-TCMR included cyclosporine use, previous acute rejection, and BK polyomavirus-associated nephropathy. The new diagnosis of CA-TCMR predicted an unfavorable prognosis in kidney allograft recipients, with an increased risk of the composite graft endpoint.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Surgery
Julie Ho, George N. Okoli, Rasheda Rabbani, Otto L. T. Lam, Viraj K. Reddy, Nicole Askin, Christie Rampersad, Aaron Trachtenberg, Chris Wiebe, Peter Nickerson, Ahmed M. Abou-Setta
Summary: This study analyzed the effectiveness of T cell-mediated rejection therapy in patients on tacrolimus and mycophenolic acid, showing that 39% of patients continued to have rejection after treatment. Pulse steroids and augmented maintenance immunosuppression were commonly used, but there was considerable practice heterogeneity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Philip F. Halloran, Katelynn S. Madill-Thomsen, Shane Pon, Majid L. N. Sikosana, Georg A. Boehmig, Jonathan Bromberg, Gunilla Einecke, Farsad Eskandary, Gaurav Gupta, Luis G. Hidalgo, Marek Myslak, Ondrej Viklicky, Agnieszka Perkowska-Ptasinska
Summary: In 398 kidney transplant biopsies with molecular antibody-mediated rejection, the 150 DSA-negative cases are earlier, less intense, and mostly C4d-negative, but use identical molecular mechanisms and have the same risk of graft loss as the 248 DSA-positive cases.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Gunilla Einecke, Jeff Reeve, Gaurav Gupta, Georg A. Boehmig, Farsad Eskandary, Jonathan S. Bromberg, Klemens Budde, Philip F. Halloran
Summary: In this study, the focus was on clinical and molecular features of kidney transplant patients after indication biopsy to predict the risk of transplant failure. The results showed that factors such as estimated GFR, proteinuria, time posttransplant, donor-specific antibody, as well as molecular and histologic features reflecting injury were more important predictors of failure compared to rejection activity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Vincent Pernin, Nicole Bec, Anais Beyze, Alexis Bourgeois, Ilan Szwarc, Coralie Champion, Anthony Chauvin, Celine Rene, Georges Mourad, Pierre Merville, Jonathan Visentin, Helene Perrochia, Lionel Couzi, Christian Larroque, Moglie Le Quintrec
Summary: The glycosylation profile of IgG3 dnDSA is associated with the risk of ABMR occurrence, with low sialylation and high GlcNAc bisection being potentially predictive factors. Further studies are needed to confirm the clinical significance of DSA glycosylation in predicting ABMR and graft survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Lynn D. Cornell
Summary: ABMR in the kidney can present with a wide range of clinical presentations and histopathologic patterns. The current Banff 2019 classification recognizes four diagnostic categories, but there are limitations in adequately representing the spectrum of antibody associated injury in allograft.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ekaterina Lezoeva, Jakob Nilsson, Rudolf Wuethrich, Thomas F. Mueller, Thomas Schachtner
Summary: Currently, there is no consensus on the treatment of borderline rejection (BLR), but high PIRCHE scores can help identify patients at high risk for immune-mediated injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Maeva Massat, Nicolas Congy-Jolivet, Anne-Laure Hebral, Laure Esposito, Olivier Marion, Audrey Delas, Magali Colombat, Stanislas Faguer, Nassim Kamar, Arnaud Del Bello
Summary: This study found that monthly infusions of tocilizumab did not alter the progression of antibodies in patients with antibody-mediated rejection resistant to standard of care therapy. There were no significant differences in graft survival and decline in renal function between patients who received tocilizumab and those who did not. Despite a decrease in inflammation and tubulitis scores, the course of antibody-mediated lesions and chronic glomerulopathy were similar in both groups.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Surgery
Edmund Huang, Angela Q. Maldonado, Christian Kjellman, Stanley C. Jordan
Summary: Imlifidase, derived from Streptococcus pyogenes, is a novel agent with potential for HLA desensitization and antibody-mediated rejection in kidney transplantation. Clinical trials have shown rapid degradation of anti-HLA donor-specific antibodies, facilitating HLA-incompatible transplantation. Early experiences with imilfidase highlight considerations regarding kinetics of antibodies, timing of complementary therapies, and interference with cross match assays.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Mark Haas, James Mirocha, Edmund Huang, Reiad Najjar, Alice Peng, Supreet Sethi, Ashley Vo, Dany Anglicheau, Stanley C. Jordan, Marion Rabant
Summary: Antibody-mediated rejection (AMR) is a major cause of kidney graft loss in transplant recipients. This study developed activity and chronicity indices based on biopsy findings to simplify the approach to AMR. The chronicity index was found to be significantly associated with graft loss, suggesting its potential value in decision-making for AMR patients.
KIDNEY INTERNATIONAL
(2023)
Article
Surgery
Jorge Chancay, Caroline Liu, Kinsuk Chauhan, Lisa Andersen, Cynthia Harris, Steven Coca, Veronica Delaney, Fasika Tedla, Graciela De Boccardo, Vinita Sehgal, Dennis Moledina, Richard Formica, Anand Reghuvaran, Khadija Banu, Sander Florman, Enver Akalin, Ron Shapiro, Fadi Salem, Madhav C. Menon
Summary: Time from transplantation to biopsy plays a crucial role in the prognosis of biopsies with histologic ABMR and MVI, potentially due to ongoing chronic allograft injury over time. Significant factors associated with outcomes include age, sex, inflammatory scores, chronicity scores, presence of DQ-DSA, and creatinine levels at biopsy, with younger age and female gender being more common in DSA-positive ABMR cases.
CLINICAL TRANSPLANTATION
(2022)
Article
Surgery
Daniel S. Ramon, Danielle M. Troop, Theresa N. Kinard, Caroline C. Jadlowiec, Margaret S. Ryan, Winston R. Hewitt, Linda G. Olsen, Andres Jaramillo, Timucin Taner, Raymond L. Heilman
Summary: Simultaneous liver-kidney transplant (SLKT) with donor-specific antibodies (DSA) is common, but after a second liver transplant, an abrupt increase in DSA levels against the kidney led to antibody-mediated rejection (AMR). The clearance of antibodies depended on the HLA antigens expressed by the transplanted liver cells.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Editorial Material
Urology & Nephrology
Antoine Creon, Elsa Ferriere, Marion Rabant, Jean-Paul Duong Van Huyen, Pierre Isnard
JOURNAL OF NEPHROLOGY
(2023)
Article
Statistics & Probability
Maarten Coemans, Geert Verbeke, Maarten Naesens
Summary: This study examines the diagnostic value of estimated glomerular filtration rate (eGFR) in kidney graft rejection by building a joint model that combines characteristics of transition models and shared parameter models. Applying the model to data from University Hospitals Leuven, the study concludes that a negative deviation from the mean eGFR slope increases the probability of rejection in indication biopsies, but using the eGFR profile alone has limited benefit for diagnosing rejection when considering biopsy history. Methodologically, the study fills a gap in the biomarker literature by relating a frequently measured continuous outcome with a less frequently measured binary indicator, and the developed joint transition model is versatile and applicable to other research settings.
STATISTICAL MODELLING
(2023)
Review
Immunology
Sukhdeep S. Jatana, Hedi Zhao, Laurine M. Bow, Emanuele Cozzi, Ibrahim Batal, Tillie Horak, Alexandre Amar-Zifkin, Carrie Schinstock, Medhat Askar, Darshana M. Dadhania, Matthew Cooper, Maarten Naesens, Edward S. Kraus, Ruth Sapir-Pichhadze
Summary: This study systematically assessed the definition and prognostic implications of HLA incompatibility in transplant outcomes, finding heterogeneity in the definition and incomplete reporting of variables. The risk of bias in studies examining the association between death-censored graft failure and HLA incompatibility was high. Therefore, optimizing HLA compatibility assessment and standardizing the reporting of variables are necessary for improving transplant outcomes and promoting international collaboration.
Article
Surgery
Anna Buxeda, Laura Llinas-Mallol, Javier Gimeno, Dolores Redondo-Pachon, Carlos Arias-Cabrales, Carla Burballa, Adrian Puche, Miguel Lopez-Botet, Jose Yelamos, Carlos Vilches, Maarten Naesens, Maria Jose Perez-Saez, Julio Pascual, Marta Crespo
Summary: Isolated microvascular inflammation (iMVI) is a rare phenotype that cannot be classified as antibody-mediated rejection (ABMR) in recent Banff classifications because it lacks HLA donor-specific antibodies or C4d deposition. In this study, we compared peripheral blood leukocyte distribution and inflammatory infiltrates in kidney transplant biopsies among ABMR, iMVI, and normal cases. We found that iMVI had fewer lymphocytes and peripheral T cells compared to ABMR and normal cases, but more NKG2A+ NK cells. iMVI also showed decreased plasma cell infiltration and increased cytotoxic T cell infiltration compared to ABMR.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medical Laboratory Technology
Alexandre Destere, Aurelie Premaud, Caroline Monchaud, Pierre Marquet, Jean-Baptiste Woillard
Summary: This study aimed to evaluate the relationship between cumulative tacrolimus exposure and the occurrence of new-onset diabetes mellitus (NODM). The study found that tacrolimus concentrations >15 mcg/L increase the risk of NODM.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Medical Laboratory Technology
Yeleen Fromage, Cyrielle Codde, Caroline Monchaud, Marc Labriffe, Minh P. Le, Jean-Francois Faucher, Jean-Baptiste Woillard
Summary: This case report reveals a significant decrease in doravirine concentration due to hemodialysis in a patient with chronic renal failure and HIV-1. Therapeutic drug monitoring is suggested in patients undergoing doravirine treatment with hemodialysis.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Immunology
Claire Tinel, Baptiste Lamarthee, Stephane Gazut, Elisabet Van Loon, Florent Von Tokarski, Aurelien Benon, Virginia Sauvaget, Victor Garcia-Paredes, Mickael Menager, Lise Morin, Laila Aouni, Nicolas Cagnard, Marion Rabant, Christophe Legendre, Fabiola Terzi, Marie Essig, Wilfried Gwinner, Maarten Naesens, Pierre Marquet, Dany Anglicheau
Summary: Increasing evidence suggests that microRNAs are involved in the pathophysiology of renal diseases, including kidney transplantation. In this study, the researchers investigated the changes in circulating microRNA expression and their involvement in antibody-mediated rejection. They found that certain microRNAs were significantly decreased in samples with rejection, and these microRNAs were associated with myeloid-related pathways and CD14+ monocytes.
Article
Immunology
Jean-Baptiste Woillard, Caroline Monchaud, Franck Saint-Marcoux, Marc Labriffe, Pierre Marquet
Summary: This study aimed to evaluate the intraindividual variability of the AUC/C0 ratio in renal transplant recipients and compare it with the variability of AUC, C0, AUC/dose, and C0/dose. The results showed that the AUC/C0 ratio had the lowest relative variation and could be used to calculate individualized C0 targets.
Article
Medical Laboratory Technology
Marc Labriffe, Ludovic Micallef, Jean-Baptiste Woillard, Caroline Monchaud, Franck Saint-Marcoux, Jean Debord, Pierre Marquet
Summary: This study investigates the relationship between mycophenolate mofetil (MMF) doses, mycophenolic acid (MPA) AUC values, and target exposure attainment in pediatric kidney transplant recipients.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Pharmacology & Pharmacy
Markus Hovd, Ida Robertsen, Jean-Baptiste Woillard, Anders Asberg
Summary: Limited sampling strategies (LSS) combined with Bayesian estimates and a population pharmacokinetic model can reduce the number of samples required for individual pharmacokinetic parameter estimations and lighten the burden of assessing AUC in therapeutic drug monitoring. This study evaluated the robustness of parameter estimations in an LSS to deviations from the optimal sample time. The investigated iohexol LSS showed good resilience to deviations in sample time.
Article
Pharmacology & Pharmacy
Adrien Paschier, Alexandre Destere, Caroline Monchaud, Marc Labriffe, Pierre Marquet, Jean-Baptiste Woillard
Summary: This study developed a population pharmacokinetic (PK) model for tacrolimus in heart transplant patients and built a maximum a posteriori Bayesian estimator (MAP-BE) based on a limited sampling strategy (LSS) to estimate the area under the curve (AUC) and trough concentration (C0). The results showed that the MAP-BE based on LSS had a small bias and imprecision compared to the reference AUC calculated using the trapezoidal rule. The probabilities of target attainment (PTAs) based on AUC or C0 allowed for new recommendations for starting doses in CYP3A5 nonexpressors and expressors.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kamile Stankeviciute, Jean-Baptiste Woillard, Richard W. Peck, Pierre Marquet, Mihaela van der Schaar
Summary: Precision medicine requires personalized modeling of disease and drug dynamics, and machine learning techniques can provide a solution. However, the complexities in both pharmacology and machine learning pose challenges and require collaboration to achieve synergistic effects.
CLINICAL PHARMACOKINETICS
(2023)
Letter
Urology & Nephrology
Angelica Pagliazzi, Elisabet Van Loon, Maarten Naesens
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Adam Wahida, Christoph Schmaderer, Maike Buettner-Herold, Caterina Branca, Sainitin Donakonda, Flora Haberfellner, Carlos Torrez, Jessica Schmitz, Tobias Schulze, Tobias Seibt, Rupert Oellinger, Thomas Engleitner, Bernhard Haller, Katja Steiger, Roman Guenthner, Georg Lorenz, Monica Yabal, Quirin Bachmann, Matthias C. Braunisch, Philipp Moog, Edouard Matevossian, Volker Assfalg, Stefan Thorban, Lutz Renders, Martin R. Spath, Roman-Ulrich Mueller, Dirk L. Stippel, Wilko Weichert, Julia Slotta-Huspenina, Sibylle von Vietinghoff, Ondrej Viklicky, Douglas R. Green, Roland Rad, Kerstin Amann, Andreas Linkermann, Jan Hinrich Brasen, Uwe Heemann, Stephan Kemmner
Summary: Renal ischemia-reperfusion injury is associated with increased risk of graft failure and mortality following renal transplantation. This study identifies high expression of RIPK3 as a potential marker for predicting one-year transplant failure.
Article
Infectious Diseases
S. Jahanbakhsh, J. Howland, M. O. Ndayishimiye Uwineza, M. T. Thwaites, C. M. Pillar, A. W. Serio, D. M. Anastasiou, D. A. Hufnagel
Summary: Omadacycline demonstrated intracellular activity against M. abscessus, similar to tigecycline, but not against clarithromycin and amikacin.
JAC-ANTIMICROBIAL RESISTANCE
(2023)