Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy

Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis

(2021) Jennifer A. Sumner et al.   Frontiers in Neuroscience

Posttraumatic Stress Disorder and Cardiovascular Disease

(2021) Christopher J. O’Donnell et al.   JAMA Cardiology

Randomized, Placebo-Controlled Trial of the Angiotensin Receptor Antagonist Losartan for Posttraumatic Stress Disorder

(2021) Murray B. Stein et al.   BIOLOGICAL PSYCHIATRY

A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank

(2020) Wenjian Bi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

(2019) Joel Gelernter et al.   NATURE NEUROSCIENCE

PRSice-2: Polygenic Risk Score software for biobank-scale data

(2019) Shing Wan Choi et al.   GigaScience

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

(2019) Caroline M. Nievergelt et al.   Nature Communications

Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records

(2018) Thomas H. McCoy et al.   BIOLOGICAL PSYCHIATRY

Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative

(2018) Caroline M. Nievergelt et al.   BIOLOGICAL PSYCHIATRY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans

(2018) Murray A. Raskind et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

(2018) David M. Howard et al.   Nature Communications

Serum cytokine levels differ according to major cardiovascular risk factors in patients with lower limb atherosclerosis

(2018) Juho Jalkanen et al.   CYTOKINE

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

(2018) Nora Franceschini et al.   Nature Communications

Efficient Genome-wide Association in Biobanks Using Topic Modeling Identifies Multiple Novel Disease Loci

(2017) Thomas H McCoy et al.   MOLECULAR MEDICINE

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

(2017) L E Duncan et al.   MOLECULAR PSYCHIATRY

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms

(2017) Brenda W.J.H. Penninx   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits

(2017) J. A. Sumner et al.   PSYCHOLOGICAL MEDICINE

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Posttraumatic stress disorder: A metabolic disorder in disguise?

(2016) Vasiliki Michopoulos et al.   EXPERIMENTAL NEUROLOGY

“Soldier's Heart”: A Genetic Basis for Elevated Cardiovascular Disease Risk Associated with Post-traumatic Stress Disorder

(2016) Harvey B. Pollard et al.   Frontiers in Molecular Neuroscience

A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces

(2015) Lynn M. Almli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene

(2015) Caroline M. Nievergelt et al.   PSYCHONEUROENDOCRINOLOGY

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Posttraumatic stress disorder and risk for coronary heart disease: A meta-analytic review

(2013) Donald Edmondson et al.   AMERICAN HEART JOURNAL

Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

(2013) Nora Franceschini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder

(2013) Pingxing Xie et al.   BIOLOGICAL PSYCHIATRY

Angiotensin Type 1 Receptor Inhibition Enhances the Extinction of Fear Memory

(2013) Paul J. Marvar et al.   BIOLOGICAL PSYCHIATRY

Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women

(2013) Guia Guffanti et al.   PSYCHONEUROENDOCRINOLOGY

A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus

(2012) M W Logue et al.   MOLECULAR PSYCHIATRY

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Pharmacological treatment of PTSD – Established and new approaches

(2011) Thomas Steckler et al.   NEUROPHARMACOLOGY