Biodegradable Metal–Organic-Frameworks-Mediated Protein Delivery Enables Intracellular Cascade Biocatalysis and Pyroptosis In Vivo

Enhanced Cancer Starvation Therapy Enabled by an Autophagy Inhibitors-Encapsulated Biomimetic ZIF-8 Nanodrug: Disrupting and Harnessing Dual Pro-Survival Autophagic Responses

(2022) Fenglan Li et al.   ACS Applied Materials & Interfaces

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED MATERIALS

Metal–Organic Framework-Based Enzyme Biocomposites

(2021) Weibin Liang et al.   CHEMICAL REVIEWS

Metal‐Organic Frameworks‐Based Antitumor Agents

(2021) Peng Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation

(2021) Min Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of Proteins to the Cytosol Using Delivery Systems with Engineered Polymer Architecture

(2021) Jessica A. Kretzmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Virus‐Spike Tumor‐Activatable Pyroptotic Agent

(2021) Sadia Nadeem et al.   Small

Correlation between Protonation of Tailor-Made Polypiperazines and Endosomal Escape for Cytosolic Protein Delivery

(2021) Franziska Hausig et al.   ACS Applied Materials & Interfaces

Phosphate-Degradable Nanoparticles Based on Metal–Organic Frameworks for Chemo-Starvation-Chemodynamic Synergistic Antitumor Therapy

(2021) Hui Peng et al.   ACS Applied Materials & Interfaces

Hypoxia‐Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild‐Photothermal Therapy

(2021) Xueqing Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

(2021) Charles L. Evavold et al.   CELL

Tumor Microenvironment-Activated Theranostics Nanozymes for Fluorescence Imaging and Enhanced Chemo-Chemodynamic Therapy of Tumors

(2021) Dong-Hui Zhao et al.   ACS Applied Materials & Interfaces

Engineering Multienzyme‐Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

(2021) Liang Zhang et al.   ADVANCED MATERIALS

Dynamic Polymer Amphiphiles for Efficient Intracellular and In Vivo Protein Delivery

(2021) Jingke Xu et al.   ADVANCED MATERIALS

A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

(2021) Xuxian Su et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

(2021) Binbin Ding et al.   NANO LETTERS

Armoring the Enzymes with Metal-Organic Frameworks

(2020) Siming Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks

(2020) Mram Z. Alyami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Observation of Amorphous Precursor Phases in the Nucleation of Protein–Metal–Organic Frameworks

(2020) Alana F. Ogata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

(2020) Zhao Wang et al.   ACS Applied Materials & Interfaces

Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

(2020) Evelyn Ploetz et al.   ADVANCED MATERIALS

Self‐Boosting Catalytic Nanoreactor Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis

(2020) Junjie Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Hypoxia‐instructed pro‐protein therapy assisted with self‐catalyzed nanozymogen

(2020) Xudong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery

(2020) Ji Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Na2S2O8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

(2020) Yang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

(2020) Hailong Tian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing

(2019) Xiaoti Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy

(2019) Li-Sen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of Nanocarriers for Intracellular Protein Delivery

(2019) Xiaofei Qin et al.   ADVANCED MATERIALS

Enzyme-Instructed Activation of Pro-protein Therapeutics In Vivo

(2019) Jin Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomineralized Metal-Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins

(2018) Ting-Ting Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing

(2018) Jin Chang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

(2018) Baojin Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal–Organic Framework Engenders Thermal and Long-Term Stability

(2016) Peng Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Stable metal-organic frameworks containing single-molecule traps for enzyme encapsulation

(2015) Dawei Feng et al.   Nature Communications

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

(2015) Kang Liang et al.   Nature Communications

The Chemistry and Applications of Metal-Organic Frameworks

(2013) H. Furukawa et al.   SCIENCE

Tailoring nanocarriers for intracellular protein delivery

(2011) Zhen Gu et al.   CHEMICAL SOCIETY REVIEWS