Article
Nutrition & Dietetics
Marek Kluza, Sylwia Paszek, Katarzyna Kluza, Slawomir Januszek, Natalia Potocka, Marzena Skrzypa, Alina Zuchowska, Andrzej Wrobel, Piotr Baszuk, Wojciech Marciniak, Marcin Misiek, Jan Lubinski, Jacek Gronwald, Izabela Zawlik, Tomasz Kluz
Summary: This study investigated the correlation between serum selenium levels and the occurrence of ovarian cancer. The results showed that women with ovarian cancer had significantly lower mean selenium concentration compared to the control group. Further analysis indicated a clear association between low selenium concentration and the occurrence of ovarian cancer.
Article
Endocrinology & Metabolism
Naser Owji, Fatemeh Moradi, Mohammad Reza Khalili, Hamidreza Jahanbani-Ardakani
Summary: This study found a reverse association between serum selenium levels and thyroid hormones in patients with Graves disease, with differences observed between the groups with and without orbitopathy. However, there were no significant differences in serum selenium levels between the GO and GD groups compared to the control group.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Yuni Hisbiyah, Anang Endaryanto, Bagus Setyoboedi, Nur Rochmah, Muhammad Faizi, Katherine Fedora
Summary: This study finds that low selenium levels are associated with autoimmune thyroid disease (AITD) in children with Down syndrome. The levels of selenoprotein-P (SePP) and glutathione peroxidase-3 (GPx3) are correlated with AITD. Therefore, it is recommended to increase selenium levels through the consumption of selenium-rich foods to reduce the risks of AITD and thyroid dysfunction in children with Down syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ann-Elin Meling Stokland, Grethe Ueland, Kari Lima, Kaja Gronning, Trine E. Finnes, Margrethe Svendsen, Aneta Ewa Tomkowicz, Synnove Emblem Holte, Stina Therese Sollid, Aleksandra Debowska, Hallvard Singsas, Marthe Landsverk Rensvik, Helle Lejon, Dag-Erik Sormo, Anders Svare, Sigrid Blika, Petya Milova, Elin Korsgaard, Oystein Husby, Lars Breivik, Anders P. Jorgensen, Eystein Sverre Husebye
Summary: Autoimmune thyroid disease is a common comorbidity in autoimmune Addison disease (AAD). This study found that 48% of AAD patients had autoimmune thyroid disease, with 42% having autoimmune hypothyroidism. Among the patients diagnosed with autoimmune hypothyroidism, 20% had overt hypothyroidism, 73% had subclinical hypothyroidism, and 7% had normal thyroid function. A significant percentage of patients had negative thyroid peroxidase antibodies. The majority of patients were treated with levothyroxine, while a small percentage received combination therapy or no treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Nadia Sawicka-Gutaj, Dawid Gruszczynski, Natalia Zawalna, Kacper Nijakowski, Ilaria Muller, Tomasz Karpinski, Mario Salvi, Marek Ruchala
Summary: This systematic review revealed significant alterations in the diversity and composition of intestinal microbiota in both GD and HT patients, with HT patients showing higher diversity indices and GD patients showing lower values. Thyroid peroxidase antibodies showed significant correlations between bacterial levels and thyroid functional parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Gelsy Arianna Lupoli, Marco Tasso, Luisa Costa, Francesco Caso, Raffaele Scarpa, Antonio Del Puente, Rosario Peluso
Summary: The study found that about one-third of patients with Hashimoto's thyroiditis have joint involvement, but the prevalence of inflammatory arthropathy is only 8.33%. Additionally, 34.26% of patients have other coexisting autoimmune disorders, with a significant prevalence of celiac disease.
Review
Endocrinology & Metabolism
Viktor Kravchenko, Tamara Zakharchenko
Summary: Thyroid hormones and essential elements such as iodine, selenium, iron, copper, zinc, calcium, and magnesium play important roles in various organs and systems of the body, including the immune system and the thyroid gland, and disruptions in their supply can cause pathological changes. This review examines the immunomodulatory role of thyroid hormones and minerals, their properties, and their involvement in the pathogenesis of autoimmune thyroid diseases. It also discusses the imbalance between oxidants and antioxidants and the potential use of immunocorrection with dietary supplements in the treatment and prevention of autoimmune thyroid diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Shenghui Ge, Junyu Zhao, Jinming Yao, Hang Fu, Yutian Tian, Yuanyuan Shan, Mengli Sun, Jing Feng, Jianjun Dong, Lin Liao
Summary: This study investigated the relationship between serum selenium levels and papillary thyroid cancer (PTC) in a Chinese population. The results showed that serum selenium levels were lower in female PTC patients compared to males, and high serum selenium levels may be a protective factor for PTC patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Nicole Lafontaine, Scott G. Wilson, John P. Walsh
Summary: This review summarizes the current understanding of DNA methylation (DNAm) in autoimmune thyroid disease (AITD), highlighting differential DNAm in several genes implicated in AITD. However, further replication and functional studies are needed to support the causal roles of these differential DNAm in AITD pathogenesis. Additionally, the influence of thyroid hormones on DNAm and the confounding effects of reverse causation need to be considered. Recent studies suggest a potential mechanism for the association between iodine and AITD through differential DNAm patterns in candidate genes. The research focus is shifting towards epigenome-wide studies to elucidate the role of DNAm in AITD and identify diagnostic, prognostic, and therapeutic targets.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Immunology
Tatjana Zake, Ieva Kalere, Sabine Upmale-Engela, Simons Svirskis, Gita Gersone, Andrejs Skesters, Valerija Groma, Ilze Konrade
Summary: The study found no significant differences in Th17-related cytokine levels in newly diagnosed GD and HT patients. In HT patients, IL-17a levels were positively correlated with other cytokines, while in GD patients, IL-17a levels were positively correlated with IL-22 and IL-23. Plasma selenium levels were negatively correlated with antibody titers in HT patients.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Medicine, General & Internal
Maria Pina Dore, Giuseppe Fanciulli, Malik Rouatbi, Sandro Mereu, Giovanni Mario Pes
Summary: This retrospective case-control study aimed to explore the prevalence of thyroid disorders (TDs) in adult celiac patients from Northern Sardinia. The results showed a significantly higher incidence of autoimmune thyroid disorders in celiac patients compared to non-autoimmune thyroid disorders. These results suggest the need for surveillance for thyroid disorders in patients with celiac disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Chao-Wen Cheng, Kam-Tsun Tang, Wen-Fang Fang, Ting- Lee, Jiunn-Diann Lin
Summary: In this study, the association between serum IFN-beta levels and AITD was explored in an ethnic Chinese population. It was found that serum IFN-beta levels were lower in HT patients and correlated with TSHRA beta and BAFF levels, but the correlations were gender-specific. Larger studies are needed to confirm these findings.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Teresa Urbano, Tommaso Filippini, Daniela Lasagni, Tiziana De Luca, Peter Grill, Sabrina Sucato, Elisa Polledri, Guy Djeukeu Noumbi, Marcella Malavolti, Annalisa Santachiara, Thelma A. Pertinhez, Roberto Baricchi, Silvia Fustinoni, Bernhard Michalke, Marco Vinceti
Summary: Selenium is a trace element with toxic and nutritional properties that can increase the risk of type 2 diabetes and NAFLD with excess intake. This study found a positive association between overall selenium exposure, especially certain chemical forms, and ALT levels, even at levels considered safe.
Article
Medical Laboratory Technology
Luping Gong, Guoqing Huang, Linjie Weng, Jialu Xu, Yan Li, Wugeng Cui, Mingcai Li
Summary: This study found that GD patients have decreased serum IL-41 levels, and IL-41 plays a potential role in abnormal immune response of GD patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, Research & Experimental
Hui Liu, Yuqi Wang, Peng Wang, Xin Wang, Yunyun Yi, Xin Li
Summary: Autoimmune hepatitis (AIH) is often complicated with immune diseases, which greatly affected the course and clinical outcome of AIH. In this retrospective study of AIH patients, the prevalence of immune diseases was 26.5%, with connective tissue disease being the most common. Patients with AIH and thyroid dysfunction had a worse prognosis, while ANA negative can be used as an independent indicator to predict the poor prognosis of AIH.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
