Article
Cell Biology
Nathalie Scrima, Romain Le Bars, Quentin Nevers, Damien Glon, Guillaume Chevreux, Ahmet Civas, Danielle Blondel, Cecile Lagaudriere-Gesbert, Yves Gaudin
Summary: Rabies virus P protein can inhibit interferon production by binding to TBK1, which is a key kinase in interferon induction pathways. This study reveals that upon RABV infection or detection of dsRNA, TBK1 and its adaptor proteins can form liquid condensates in the cytoplasm, and P protein binding disrupts the formation of these structures.
Article
Cell Biology
Baoming Xie, Mingqiu Zhao, Dan Song, Keke Wu, Lin Yi, Wenhui Li, Xiaoming Li, Kun Wang, Jinding Chen
Summary: The study revealed that CSFV infection inhibits the phosphorylation of MTOR leading to autophagy initiation. The MAPK/ERK signaling pathway is involved in CSFV-induced autophagy. CSFV non-structural protein NS5A induced autophagy through the CAMKK2-PRKAA-MTOR signaling pathway.
Review
Plant Sciences
Yugo Lima-Melo, Mehmet Kilic, Eva-Mari Aro, Peter J. Gollan
Summary: Photosynthesis is a crucial process for harnessing energy, and Photosystem I (PSI) plays a key role in balancing energy harvesting and utilization. Damage to PSI can have significant impacts on plant photosynthetic efficiency. Understanding the protection mechanisms and impact of PSI photoinhibition on signaling and metabolism is essential for improving photosynthetic efficiency in crop species.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Immunology
Yuke Gao, Yangyi Li, Zaihuan Lin, Yuxin Zeng, Zhengrong Huang, Linzhi Han, Yahua Zhong, Yan Gong, Qiuji Wu, Conghua Xie
Summary: This study found that ionizing radiation can promote PD-L1 expression in macrophages, and ATM kinase inhibitor further enhances this effect. ATM inhibition leads to DNA damage, which activates the STING/IRF3 signaling pathway, upregulates type I interferon expression in macrophages, and ultimately leads to PD-L1 upregulation. ATM inhibition also increases CD8(+) T cell infiltration induced by IR and promotes anti-tumor efficacy in vivo.
Article
Pharmacology & Pharmacy
Andrea Marcellini, Dawid Swieboda, Anabel Guedan, Stuart N. Farrow, Paolo Casolari, Marco Contoli, Sebastian L. Johnston, Alberto Papi, Roberto Solari
Summary: The study found that inhaled corticosteroids may inhibit the innate antiviral immune response, leading to an increase in viral replication. This could have significant clinical implications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R. Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F. Dagley, Michael J. Mlodzianoski, Kelly L. Rogers, Thomas Zillinger, Gunther Hartmann, Michael P. Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L. Masters
Summary: Deficiency in COPI complex I may lead to aberrant activation of the STING pathway and inflammatory diseases, with cGAS possibly being the upstream immune sensor driving this process. Targeted inhibition of the cGAS/STING pathway can alleviate inflammation in diseases such as COPA syndrome.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Shannon M. Reilly, Mohammad Abu-Odeh, Magdalene Ameka, Julia H. DeLuca, Meghan C. Naber, Benyamin Dadpey, Nima Ebadat, Andrew Gomez, Xiaoling Peng, BreAnne Poirier, Elyse Walk, Matthew J. Potthof, Alan R. Saltiel
Summary: Amlexanox improves metabolic health by promoting adipose tissue browning and increasing energy expenditure, achieved through the action of FGF21 and IL-6. Adipocyte-derived IL-6 inhibits hepatic gluconeogenesis by activating STAT3, while FGF21 promotes browning of adipose tissue, leading to weight loss and improved insulin sensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Xiao Li, Xinyuan Sun, Zhongyi Yan, Zhenxiang Zhao, Zhaojun Pang, Han Yang, Xiaoxin Ji, Yi Lei, Zixiang Zhu, Xiangqian Guo, Xin Mu
Summary: A study has found that an antibiotic called gramicidin A can enhance MDA5-mediated interferon signaling by increasing the oligomerization of MDA5 and dsRNA.
Article
Dermatology
Xiaoli Min, Meiling Zheng, Yaqin Yu, Jiali Wu, Qiqi Kuang, Zhi Hu, Lianlian Ouyang, Shuang Lu, Ming Zhao
Summary: This study reveals that UVB irradiation activates human endogenous retroviruses (HERVs), leading to immune response. The study also suggests that UVB-induced overexpression of HERV-dsRNA promotes the production of type I interferon, which contributes to skin inflammatory response and skin lesions in SLE/DLE.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Virology
Xiao Yang, Mingming Wan, Linjun Cai, Ali Hou, Bo Sun, Yan Zhou, Feng Gao, Weiheng Su, Chunlai Jiang
Summary: Inactivated vaccines based on cell culture are valuable in disease prevention and control. Using human diploid cells for vaccine production presents challenges, but inhibiting the interferon response increased virus production, leading to the establishment of a stable cell line and a pilot scale virus production platform for rabies vaccines.
Article
Biochemistry & Molecular Biology
Hua-Yang Guo, Hong-Xi He, Bao-Suo Liu, Nan Zhang, Ke-Cheng Zhu, Dian-Chang Zhang
Summary: Interferon regulatory factor 7 (IRF7) regulates type I interferon (IFN) genes in the immune response against bacteria. In this study, IRF7 and two IFNa3s (IFNa3 and IFNa3-like) were identified in A. latus. AlIRF7 is expressed in various organs with high levels in the spleen and liver. S. iniae challenge promoted the expression of AlIRF7 in multiple organs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Shanlong Zhang, Li Kang, Xiaoxue Dai, Junlan Chen, Zhengtao Chen, Meixiang Wang, Huantong Jiang, Xin Wang, Suqin Bu, Xinyuan Liu, Guohui Zhang, Hua Tang
Summary: This study found that administration of MnCl2 to tumor cells induces lipid peroxidation and increased mitochondrial ROS levels, leading to ferroptosis. Additionally, the activated cGAS-STING signaling pathway by manganese treatment promotes mitochondrial lipid peroxidation and ROS production, resulting in ferroptosis in tumor cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Oyahida Khatun, Mansi Sharma, Rohan Narayan, Shashank Tripathi
Summary: Evasion and antagonism of host cellular immunity provide replication advantage to SARS-CoV-2. ORF6 protein was found to mitigate type-I interferon induction and signaling. ORF6 directly interacts with RIG-I and reduces K63-linked ubiquitinated RIG-I, blocking downstream type-I interferon induction and signaling. These findings contribute to understanding how SARS-CoV-2 evades the host immune response.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Genetics & Heredity
Christopher J. A. Duncan, Richard E. Randall, Sophie Hambleton
Summary: IFN-I is essential in antiviral immunity, with most pathogenic viruses evolving countermeasures against it. Recent discoveries of genetic defects in IFN-I signaling shed light on the importance of IFN-III in humans, enhancing our understanding of the role of the IFN system in the antiviral response.
TRENDS IN GENETICS
(2021)
Article
Plant Sciences
Zheng Jin, Yuan Luo, Huanyi Zhao, Jiayan Cui, Weifeng He, Junlong Li, Jianbin Pi, Lijin Qing, Wei Wu
Summary: This study investigated the effect and mechanism of Qingre Huoxue Decoction (QRHX) on the treatment of atherosclerosis (AS) using both in vivo and in vitro experiments. The results demonstrated that QRHX induced M2 polarization of macrophages through the NF-kappa B signaling pathway, leading to reduced inflammatory response and stabilization of plaques.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yuji Fujii, Mihoko Hirayama, Shoko Nishiyama, Tatsuki Takahashi, Misuzu Okajima, Fumiki Izumi, Kazuaki Takehara, Tatsunori Masatani, Makoto Sugiyama, Naoto Ito
Summary: This study found that migratory birds may play an important role in the global spread of avian rotaviruses that are pathogenic in mammals by analyzing the genetic characteristics of the RK1 strain.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Microbiology
Ian Cary B. Prado, Larry Xerxes B. Capuno, Princess DLP. Collera, Aaron Paul D. Cabralda, Kristina Andrea S. De Ramos, John Michael G. Bernardo, Billy P. Divina, Tatsunori Masatani, Tetsuya Tanaka, Remil L. Galay
Summary: Tick-borne protozoan parasites Babesia and Theileria can cause economic losses in the cattle industry. This study investigated the presence of these parasites in large ruminants in the Philippines, confirming the prevalence of T. orientalis and reporting the genetic diversity of B. bovis and T. orientalis.
Review
Immunology
Junna Kawasaki, Keizo Tomonaga, Masayuki Horie
Summary: Zoonotic diseases have a significant impact on public health and socioeconomics. RNA viruses are responsible for the majority of zoonotic diseases, highlighting the need to investigate RNA viruses in animals. There are still many animal viruses capable of infecting humans yet to be discovered, indicating a lack of understanding of viral diversity. High-throughput sequencing has allowed for the identification of viral infections with minimal bias, revealing hidden viral infections in both symptomatic and asymptomatic animals. This review discusses the history, current limitations, and future potential of viral searches using high-throughput sequencing technology, and summarizes recent large-scale investigations of viral infections using public databases.
MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Virology
Sumire Mitarai, Kosuke Okuya, Kazuhiro Miyane, Machiko Miyamoto, Shingo Ishikawa, Hiroaki Kawaguchi, Itaru Hatazoe, Yasuo Suda, Eriko Arima, Hiroshi Nakazato, Seiji Hobo, Tatsunori Masatani, Makoto Ozawa
Summary: A study conducted genetic sequencing on Bovine respiratory syncytial virus (BRSV) strains detected in Kagoshima prefecture and isolated in Hokkaido between 2017 and 2019, and compared them to a BRSV vaccine strain. The Japanese BRSV strains were found to be genetically similar to each other but different from the vaccine strain. Specific amino acid differences were identified in the glycoprotein (G protein) of the recent Japanese BRSV strains, suggesting potential antigenic differences from the vaccine strains.
ARCHIVES OF VIROLOGY
(2023)
Article
Immunology
Nonoka Matsunaga, Moe Ijiri, Kemi Ishikawa, Makoto Ozawa, Kosuke Okuya, Ahmed Magdy Khalil, Isshu Kojima, Mana Esaki, Tatsunori Masatani, Tsutomu Matsui, Yoshikazu Fujimoto
Summary: This study conducted the first epidemiological survey of APMV-1 in Japan, and found that environmental water samples could be an effective method for detecting the virus in wild birds. The results also showed the continuous presence of APMV-1 strains with potential pathogenicity to chickens, circulating among waterfowl in Far East Asian countries.
MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Virology
Takashi Kajiya, Hayate Sawayama, Eriko Arima, Mika Okamoto, Masanori Baba, Masaaki Toyama, Kosuke Okuya, Makoto Ozawa, Nobuhiko Atsuchi, Junichiro Nishi, Yasuo Suda
Summary: This study provides a follow-up on hospitalized COVID-19 patients and explores the impact of SARS-CoV-2 variants on recovery time. The findings demonstrate that patients infected with the Delta variant have a longer recovery period, and the SGNP method shows a stronger correlation with patient symptoms compared to the commonly used Qiagen method.
Article
Biochemistry & Molecular Biology
Yuya Hirai, Masayuki Horie
Summary: Researchers have discovered that Nyamanini virus (NYMV), a tick-borne mononegavirus, forms inclusion bodies (IBs) in the nucleus of infected cells. They found that these IBs consist of condensates and puncta of various sizes and morphologies. Additionally, the expression of NYMV nucleoprotein (N) and phosphoprotein (P) alone can induce the formation of condensates and puncta in the nucleus, respectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Kosuke Okuya, Ahmed Magdy Khalil, Mana Esaki, Natsuko Nishi, Donna Koyamada, Rara Saito, Kaori Tokorozaki, Taichi Hasegawa, Makoto Ozawa
Summary: During the 2020/21 winter season in Kagoshima prefecture, Japan, both H5N8 high pathogenicity avian influenza viruses (HPAIVs) and low pathogenicity avian influenza viruses (LPAIVs) of various subtypes were isolated from environmental water and wild birds. The H5 HPAIVs belonged to two different clusters, and the H5N8 HPAIVs could be classified into six genotypes. The study emphasizes the importance of monitoring both HPAIV and LPAIV to better understand avian influenza ecology in migratory waterfowl populations.
JOURNAL OF GENERAL VIROLOGY
(2023)
Article
Virology
Hayato Harima, Yongjin Qiu, Junya Yamagishi, Masahiro Kajihara, Katendi Changula, Kosuke Okuya, Mao Isono, Tomoyuki Yamaguchi, Hirohito Ogawa, Naganori Nao, Michihito Sasaki, Edgar Simulundu, Aaron S. Mweene, Hirofumi Sawa, Kanako Ishihara, Bernard M. Hang'ombe, Ayato Takada
Summary: Novel gammaherpesviruses were isolated from bats in Zambia, expanding our knowledge on the genetic diversity of herpesviruses in African bats.
Article
Virology
Bea Clarise B. Garcia, Yahiro Mukai, Keizo Tomonaga, Masayuki Horie
Summary: This study developed a new strategy to detect endogenous bornavirus-like elements (EBLX/Ps) derived from orthobornaviral X and P genes. It found that an EBLX/P is expressed as a fusion transcript with the cellular gene ZNF451, potentially encoding the ZNF451/EBLP fusion protein in bat cells.
Article
Immunology
Kosuke Okuya, Junki Mine, Kaori Tokorozaki, Isshu Kojima, Mana Esaki, Kohtaro Miyazawa, Ryota Tsunekuni, Saki Sakuma, Asuka Kumagai, Yoshihiro Takadate, Yuto Kikutani, Tsutomu Matsui, Yuko Uchida, Makoto Ozawa
Summary: Genetic analyses revealed the coexistence of two genetic groups of highly pathogenic avian influenza H5 subtype viruses among migratory waterfowl in the Izumi Plain, Japan. Continuous surveillance and timely information sharing are crucial for rapid risk assessment.
EMERGING INFECTIOUS DISEASES
(2022)