Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling

Predicted Structures of the Proton-Bound Membrane-Embedded Rotor Rings of the Saccharomyces cerevisiae and Escherichia coli ATP Synthases

(2016) Wenchang Zhou et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

(2016) Alexander Hahn et al.   MOLECULAR CELL

Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase

(2015) Matteo Allegretti et al.   NATURE

On the principle of ion selectivity in Na+/H+-coupled membrane proteins: Experimental and theoretical studies of an ATP synthase rotor

(2015) Vanessa Leone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of ATP synthase fromParacoccus denitrificansdetermined by X-ray crystallography at 4.0 Å resolution

(2015) Edgar Morales-Rios et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

(2015) Anna Zhou et al.   eLife

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

Half channels mediating H+ transport and the mechanism of gating in the Fo sector of Escherichia coli F1Fo ATP synthase

(2014) Robert H. Fillingame et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ATP synthase in mycobacteria: Special features and implications for a function as drug target

(2014) Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I

(2014) V. R. I. Kaila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution structure and mechanism of an F/V-hybrid rotor ring in a Na+-coupled ATP synthase

(2014) Doreen Matthies et al.   Nature Communications

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

(2014) Thomas Eicher et al.   eLife

Sequence co-evolution gives 3D contacts and structures of protein complexes

(2014) Thomas A Hopf et al.   eLife

The ATP synthase: the understood, the uncertain and the unknown

(2013) John E. Walker   BIOCHEMICAL SOCIETY TRANSACTIONS

ATP Synthase: A Molecular Therapeutic Drug Target for Antimicrobial and Antitumor Peptides

(2013) Zulfiqar Ahmad et al.   CURRENT MEDICINAL CHEMISTRY

TMC207 becomes bedaquiline, a new anti-TB drug

(2013) Juan Carlos Palomino et al.   Future Microbiology

Residues in the Polar Loop of SubunitcinEscherichia coliATP Synthase Function in Gating Proton Transport to the Cytoplasm

(2013) P. Ryan Steed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Type of Na+-Driven ATP Synthase Membrane Rotor with a Two-Carboxylate Ion-Coupling Motif

(2013) Sarah Schulz et al.   PLOS BIOLOGY

Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing

(2012) Thomas A. Hopf et al.   CELL

Protein structure prediction from sequence variation

(2012) Debora S Marks et al.   NATURE BIOTECHNOLOGY

Structure of the c10 ring of the yeast mitochondrial ATP synthase in the open conformation

(2012) Jindrich Symersky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oligomycin frames a common drug-binding site in the ATP synthase

(2012) J. Symersky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering rotor ring stoichiometries in the ATP synthase

(2012) D. Pogoryelov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Realistic simulations of the coupling between the protomotive force and the mechanical rotation of the F0-ATPase

(2012) S. Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats

(2011) Sebastian Radestock et al.   JOURNAL OF MOLECULAR BIOLOGY

HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment

(2011) Michael Remmert et al.   NATURE METHODS

Protein 3D Structure Computed from Evolutionary Sequence Variation

(2011) Debora S. Marks et al.   PLoS One

Essential arginine residue of the Fo-asubunit in FoF1-ATP synthase has a role to prevent the proton shortcut withoutc-ring rotation in the Foproton channel

(2010) Noriyo Mitome et al.   BIOCHEMICAL JOURNAL

Proton transport coupled ATP synthesis by the purified yeast H+-ATP synthase in proteoliposomes

(2010) Kathrin Förster et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structural and energetic basis for H+ versus Na+ binding selectivity in ATP synthase Fo rotors

(2010) Alexander Krah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

On the Question of Hydronium Binding to ATP-Synthase Membrane Rotors

(2010) Vanessa Leone et al.   BIOPHYSICAL JOURNAL

Chemical Reactivities of Cysteine Substitutions in Subunitaof ATP Synthase Define Residues Gating H+Transport from Each Side of the Membrane

(2010) Hui Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microscopic rotary mechanism of ion translocation in the Fo complex of ATP synthases

(2010) Denys Pogoryelov et al.   Nature Chemical Biology

Cryo-EM of macromolecular assemblies at near-atomic resolution

(2010) Matthew L Baker et al.   Nature Protocols

A New Type of Proton Coordination in an F1Fo-ATP Synthase Rotor Ring

(2010) Laura Preiss et al.   PLOS BIOLOGY

A more robust version of the Arginine 210-switched mutant in subunit a of the Escherichia coli ATP synthase

(2009) Leon Bae et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Aqueous Accessibility to the Transmembrane Regions of Subunitcof the Escherichia coli F1F0ATP Synthase

(2009) P. Ryan Steed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete Ion-Coordination Structure in the Rotor Ring of Na+-Dependent F-ATP Synthases

(2009) Thomas Meier et al.   JOURNAL OF MOLECULAR BIOLOGY

Refinement of Protein Structures into Low-Resolution Density Maps Using Rosetta

(2009) Frank DiMaio et al.   JOURNAL OF MOLECULAR BIOLOGY

On the Structure of the Proton-Binding Site in the Fo Rotor of Chloroplast ATP Synthases

(2009) Alexander Krah et al.   JOURNAL OF MOLECULAR BIOLOGY

High-resolution structure of the rotor ring of a proton-dependent ATP synthase

(2009) Denys Pogoryelov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Cytoplasmic Loops of SubunitaofEscherichia coliATP Synthase May Participate in the Proton Translocating Mechanism

(2008) Kyle J. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SubunitaFacilitates Aqueous Access to a Membrane-embedded Region of SubunitcinEscherichia coliF1F0ATP Synthase

(2008) P. Ryan Steed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Interactions between Transmembrane Helices 4 and 5 of Subunitaand the SubunitcRing ofEscherichia coliATP Synthase

(2008) Kyle J. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP Synthase and the Actions of Inhibitors Utilized To Study Its Roles in Human Health, Disease, and Other Scientific Areas

(2008) S. Hong et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

ATP synthesis without R210 of subunit a in the Escherichia coli ATP synthase

(2007) Robert R. Ishmukhametov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS