Gastrointestinal mucosal barrier function and diseases

Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis

(2016) Sun A Kim et al.   BRITISH JOURNAL OF CANCER

Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model

(2016) Liping Wu et al.   JOURNAL OF GASTROENTEROLOGY

Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome

(2016) Julien Bertrand et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Histological Response to Fluticasone Propionate in Patients With Eosinophilic Esophagitis Is Associated With Improved Functional Esophageal Mucosal Integrity

(2015) Bram D van Rhijn et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Endoscopic Mucosal Impedance Measurements Correlate With Eosinophilia and Dilation of Intercellular Spaces in Patients With Eosinophilic Esophagitis

(2015) David A. Katzka et al.   Clinical Gastroenterology and Hepatology

Increased permeability of the epithelium of middle ear cholesteatoma

(2015) H. Koizumi et al.   CLINICAL OTOLARYNGOLOGY

Intestinal E-cadherin Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis

(2015) Jessica I. Grill et al.   DIGESTIVE DISEASES AND SCIENCES

Intestinal Permeability in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: Is There a Place for Glutamine Supplementation?

(2015) Moïse Coëffier et al.   GASTROENTEROLOGY

MicroRNA 29 Targets Nuclear Factor-κB–Repressing Factor and Claudin 1 to Increase Intestinal Permeability

(2015) QiQi Zhou et al.   GASTROENTEROLOGY

Mucosal Impedance Discriminates GERD From Non-GERD Conditions

(2015) Fehmi Ates et al.   GASTROENTEROLOGY

Intestinal deletion ofClaudin-7enhances paracellular organic solute flux and initiates colonic inflammation in mice

(2015) Hiroo Tanaka et al.   GUT

Genes involved in the regulation of intestinal permeability and their role in ulcerative colitis

(2015) Matthias Prager et al.   Journal of Digestive Diseases

Reproducibility crisis: Blame it on the antibodies

(2015) Monya Baker   NATURE

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

Effects of Topical Steroids on Tight Junction Proteins and Spongiosis in Esophageal Epithelia of Patients With Eosinophilic Esophagitis

(2014) David A. Katzka et al.   Clinical Gastroenterology and Hepatology

Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis

(2014) Jing Shan et al.   JOURNAL OF GASTROENTEROLOGY

Food antigen-induced immune responses in Crohn’s disease patients and experimental colitis mice

(2014) Takaaki Kawaguchi et al.   JOURNAL OF GASTROENTEROLOGY

Evidence-based clinical practice guidelines for irritable bowel syndrome

(2014) Shin Fukudo et al.   JOURNAL OF GASTROENTEROLOGY

Distinct Patterns of IgG and IgA against Food and Microbial Antigens in Serum and Feces of Patients with Inflammatory Bowel Diseases

(2014) Lisa Frehn et al.   PLoS One

Histomorphological differentiation of non-erosive reflux disease and functional heartburn in patients with PPI-refractory heartburn

(2013) A. Kandulski et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mast Cell Tryptase Reduces Junctional Adhesion Molecule-A (JAM-A) Expression in Intestinal Epithelial Cells: Implications for the Mechanisms of Barrier Dysfunction in Irritable Bowel Syndrome

(2013) Ewa M Wilcz-Villega et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Alterations in junctional proteins, inflammatory mediators and extracellular matrix molecules in eosinophilic esophagitis

(2013) Solange M. Abdulnour-Nakhoul et al.   CLINICAL IMMUNOLOGY

Beyond Gene Discovery in Inflammatory Bowel Disease: The Emerging Role of Epigenetics

(2013) Nicholas T. Ventham et al.   GASTROENTEROLOGY

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

(2013) Hanne Vanheel et al.   GUT

Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation

(2013) M Vivinus-Nébot et al.   GUT

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium

(2013) Hao Chen et al.   GUT

Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: a characteristic pattern is associated with sessile serrated lesion

(2013) Kazuhiro Sentani et al.   HISTOPATHOLOGY

Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS

(2013) E. Wilcz-Villega et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Down-Regulation of Claudin-18 Is Associated with the Proliferative and Invasive Potential of Gastric Cancer at the Invasive Front

(2013) Tadayuki Oshima et al.   PLoS One

Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro

(2013) Eleonora Victoria Charlotta Björkman et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Relevance of Ultrastructural Alterations of Intercellular Junction Morphology in Inflamed Human Esophagus

(2013) Chia-Chin Liu et al.   Journal of Neurogastroenterology and Motility

The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations

(2012) Cristina Martínez et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins

(2012) Xin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of tight junction proteins in gastroesophageal reflux disease

(2012) Klaus Mönkemüller et al.   BMC GASTROENTEROLOGY

Down-Regulation of Claudin-3 Is Associated with Proliferative Potential in Early Gastric Cancers

(2012) Takuya Okugawa et al.   DIGESTIVE DISEASES AND SCIENCES

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

(2012) Cristina Martínez et al.   GUT

The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype

(2011) Nathalie Bertiaux-Vandaële et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease

(2011) Biljana Jovov et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Esophageal Acid Exposure Decreases Intraluminal Baseline Impedance Levels

(2011) Boudewijn F Kessing et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Establishment of esophageal-like non-keratinized stratified epithelium using normal human bronchial epithelial cells

(2011) Tadayuki Oshima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins

(2011) Xin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Leaky Gut in Patients with Diarrhea-Predominant Irritable Bowel Syndrome and Inactive Ulcerative Colitis

(2011) Krisztina Gecse et al.   DIGESTION

Predicted expansion of the claudin multigene family

(2011) Katsuhiko Mineta et al.   FEBS LETTERS

Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice

(2011) Daisuke Hayashi et al.   GASTROENTEROLOGY

Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique

(2011) R. Farre et al.   GUT

Eosinophilic esophagitis: Updated consensus recommendations for children and adults

(2011) Chris A. Liacouras et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease

(2011) Masako Oguro et al.   JOURNAL OF GASTROENTEROLOGY

Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers

(2011) Tadayuki Oshima et al.   LABORATORY INVESTIGATION

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation

(2011) P Dhawan et al.   ONCOGENE

Refractory Heartburn: Comparison of Intercellular Space Diameter in Documented GERD vs. Functional Heartburn

(2010) Marcelo F Vela et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis

(2010) Alexandra–Chloé Villani et al.   GASTROENTEROLOGY

Coordinate Interaction between IL-13 and Epithelial Differentiation Cluster Genes in Eosinophilic Esophagitis

(2010) C. Blanchard et al.   JOURNAL OF IMMUNOLOGY

The Expression of Claudin-1, Claudin-2, Claudin-3, and Claudin-4 in Gastric Cancer Tissue

(2010) Hun Jung et al.   JOURNAL OF SURGICAL RESEARCH

Immunohistochemical analysis of colorectal cancer with gastric phenotype: Claudin-18 is associated with poor prognosis

(2010) Miho Matsuda et al.   PATHOLOGY INTERNATIONAL

Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome

(2009) Moïse Coëffier et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Expression of tight-junction-associated proteins in human gastric cancer: downregulation of claudin-4 correlates with tumor aggressiveness and survival

(2009) Satoshi Ohtani et al.   Gastric Cancer

Acid and weakly acidic solutions impair mucosal integrity of distal exposed and proximal non-exposed human oesophagus

(2009) R. Farre et al.   GUT

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome

(2009) Q. Zhou et al.   GUT

Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa

(2009) Hiroto Miwa et al.   JOURNAL OF GASTROENTEROLOGY

Significance of lymphatic invasion and cancer invasion-related proteins on lymph node metastasis in gastric cancer

(2009) Itaru Kamata et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Esophageal Dilated Intercellular Spaces (DIS) and Nonerosive Reflux Disease

(2008) Hannah van Malenstein et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

(2008) Stefania Vetrano et al.   GASTROENTEROLOGY

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

(2008) T Piche et al.   GUT

Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces

(2008) R Farre et al.   GUT

Changes in the expression of claudins in active ulcerative colitis

(2008) Tadayuki Oshima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

(2008) Christopher R Weber et al.   LABORATORY INVESTIGATION

Experimental oesophagitis in the rat is associated with decreased voluntary movement

(2008) h. miwa et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Hypermethylation-Modulated Downregulation of Claudin-7 Expression Promotes the Progression of Colorectal Carcinoma

(2008) Fumihito Nakayama et al.   PATHOBIOLOGY

Structure and function of claudins

(2007) Gerd Krause et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES