期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 213, 期 2, 页码 167-176出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20150785
关键词
-
资金
- American Cancer Society Institutional Research Grant [57-001-53]
T cell immunoglobulin and ITIM domain (TIG IT) and CD226 emerge as a novel T cell cosignaling pathway in which CD226 and TIG IT serve as costimulatory and coinhibitory receptors, respectively, for the ligands CD155 and CD112. In this study, we describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for human T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. We further identify that CD112, widely expressed on antigen-presenting cells and tumor cells, is the ligand for CD112R with high affinity. CD112R competes with CD226 to bind to CD112. Disrupting the CD112R-CD112 interaction enhances human T cell response. Our experiments identify CD112R as a novel checkpoint for human T cells via interaction with CD112.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据