Article
Rheumatology
Anja Strangfeld, Martin Schafer, Milena A. Gianfrancesco, Saskia Lawson-Tovey, Jean W. Liew, Lotta Ljung, Elsa F. Mateus, Christophe Richez, Maria J. Santos, Gabriela Schmajuk, Carlo A. Scire, Emily Sirotich, Jeffrey A. Sparks, Paul Sufka, Thierry Thomas, Laura Trupin, Zachary S. Wallace, Sarah Al-Adely, Javier Bachiller-Corral, Suleman Bhana, Patrice Cacoub, Loreto Carmona, Ruth Costello, Wendy Costello, Laure Gossec, Rebecca Grainger, Eric Hachulla, Rebecca Hasseli, Jonathan S. Hausmann, Kimme L. Hyrich, Zara Izadi, Lindsay Jacobsohn, Patricia Katz, Lianne Kearsley-Fleet, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
Summary: Factors associated with COVID-19-related death in people with rheumatic diseases include age, sex, comorbidities, disease activity, and specific medications. Adequate disease control with disease-modifying anti-rheumatic drugs (DMARDs) without increasing glucocorticoid dosages is important, while caution may be required with certain medications such as rituximab and sulfasalazine.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Rheumatology
Rebecca Grainger, Alfred H. J. Kim, Richard Conway, Jinoos Yazdany, Philip C. Robinson
Summary: This review summarizes the current knowledge on SARS-CoV-2 infection, COVID-19 prevention and treatment in people with rheumatic disease. It suggests that rheumatic disease is associated with a slightly higher risk of SARS-CoV-2 infection, but outcomes of COVID-19 are influenced by comorbidities and specific disease states or treatments. Further research is needed to address the specific considerations for people with rheumatic disease.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alessandro Pierri, Giulia Gagno, Alessandra Fluca, Davide Radaelli, Diana Bonuccelli, Laura Giusti, Michela Bulfoni, Antonio P. Beltrami, Aneta Aleksova, Stefano D'Errico
Summary: There is increasing evidence of cardiac involvement in COVID-19 cases, with a wide range of clinical manifestations. Acute myocarditis is a rare but frightening complication of SARS-CoV-2 infection, and most reports lack histological confirmation of cardiac injury. This case report provides microscopic and genetic evidence suggesting direct cardiac involvement compatible with fulminant myocarditis in a young lady who died suddenly after testing positive for SARS-CoV-2.
Article
Immunology
Sinem Nihal Esatoglu, Koray Tascilar, Hakan Babaoglu, Cemal Bes, Berna Yurttas, Servet Akar, Ozlem Pehlivan, Cansu Akleylek, Duygu Tecer, Emire Seyahi, Tuba Yuce-Inel, Nilufer Alpay-Kanitez, Erdal Bodakci, Emre Tekgoz, Seda Colak, Ertugrul Cagri Bolek, Suleyman Serdar Koca, Umut Kalyoncu, Ozan Cemal Icacan, Serdal Ugurlu, Hande Ece Oz, Vedat Hamuryudan, Gulen Hatemi
Summary: This study found that among patients with inflammatory rheumatic diseases (IRDs) and COVID-19, factors such as glucocorticoid use, chronic kidney disease, pulmonary disease, and obesity were associated with worse outcomes, while biologic disease-modifying antirheumatic drugs did not seem to be associated with worse outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marco Krasselt, Christoph Baerwald, Olga Seifert
Summary: Vaccination coverage against SARS-CoV-2 is high in patients with rheumatic diseases, but there is still a need for improved vaccination education.
Article
Green & Sustainable Science & Technology
Smiljana Cvjetkovic, Vida Jeremic Stojkovic, Sanja Matovic-Miljanovic, Janko Jankovic, Aleksandra Jovic Vranes, Aleksandar Stevanovic, Zeljka Stamenkovic
Summary: The lower COVID-19 vaccination rates in Western Balkans countries can be attributed to the societal distrust among citizens. A study was conducted to determine the level and predictors of societal trust in the region. The findings showed significant variations in societal trust across countries, indicating the need for tailored communication campaigns.
Article
Rheumatology
Richard Conway, Elena Nikiphorou, Christiana A. Demetriou, Candice Low, Kelly Leamy, John G. Ryan, Ronan Kavanagh, Alexander D. Fraser, John J. Carey, Paul O'Connell, Rachael M. Flood, Ronan H. Mullan, David J. Kane, Nicola Ambrose, Frances Stafford, Philip C. Robinson, Jean W. Liew, Rebecca Grainger, Geraldine M. McCarthy
Summary: This study used data from the COVID-19 Global Rheumatology Alliance to describe COVID-19 outcomes for people with rheumatic disease in Ireland. The results showed that there was no temporal trend in COVID-19-related hospitalization and mortality outcomes for these patients.
Article
Microbiology
Harald Brussow, Kenneth Timmis
Summary: COVID-19 is an acute respiratory infection that can have long-term sequelae, leading to "long covid". This disease will leave long-lasting scars on society.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Ronald L. G. Flumignan, Vinicius T. Civile, Jessica Dantas de Sa Tinoco, Patricia I. F. Pascoal, Libnah L. Areias, Charbel F. Matar, Britta Tendal, Virginia F. M. Trevisani, Alvaro N. Atallah, Luis C. U. Nakano
Summary: COVID-19 patients often develop respiratory insufficiency and may experience pulmonary microthrombosis and thromboembolic events. The use of anticoagulants can prevent and treat these thrombotic issues, but their benefits are still under debate.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Oncology
Julia Steinberg, Suzanne Hughes, Harriet Hui, Matthew J. Allsop, Sam Egger, Michael David, Michael Caruana, Peter Coxeter, Chelsea Carle, Tonia Onyeka, Isabel Rewais, Maria J. Monroy Iglesias, Nuria Vives, Feixue Wei, Derrick Bary Abila, Giulia Carreras, Marilina Santero, Emma L. O'Dowd, Gigi Lui, Musliu Adetola Tolani, Maeve Mullooly, Shing Fung Lee, Rebecca Landy, Sharon J. B. Hanley, Gemma Binefa, Charlene M. Mcshane, Muluken Gizaw, Poongulali Selvamuthu, Houda Boukheris, Annet Nakaganda, Isil Ergin, Fabio Ynoe Moraes, Nahari Timilshina, Ashutosh Kumar, Diama B. Vale, Ana Molina-Barcelo, Lisa M. Force, Denise Joan Campbell, Yuqing Wang, Fang Wan, Anna-Lisa Baker, Ramnik Singh, Rehana Abdus Salam, Susan Yuill, Richa Shah, Iris Lansdorp-Vogelaar, Aasim Yusuf, Ajay Aggarwal, Raul Murillo, Julie S. Torode, Erich V. Kliewer, Freddie Bray, Kelvin K. W. Chan, Stuart Peacock, Timothy P. Hanna, Ophira Ginsburg, Mieke Van Hemelrijck, Richard Sullivan, Felipe Roitberg, Andre M. Ilbawi, Isabelle Soerjomataram, Karen Canfell
Summary: Before COVID-19 vaccination, people with recent or active cancer had a higher risk of COVID-19-related death, with the risk depending on the type of cancer and the time since diagnosis/treatment.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Jason Bouziotis, Marianna Arvanitakis, Jean-Charles Preiser
Summary: Patients with extreme BMI may have an increased risk of death while hospitalized for COVID-19, with underweight patients having a higher mortality risk, while normal weight, overweight, and obese patients have lower mortality rates.
CLINICAL NUTRITION
(2022)
Article
Clinical Neurology
Mar Ariza, Neus Cano, Barbara Segura, Ana Adan, Nuria Bargallo, Xavier Caldu, Anna Campabadal, Maria Angeles J. Jurado, Maria Mataro, Roser Pueyo, Roser Sala-Llonch, Cristian Barrue, Javier Bejar, Claudio Ulises Cortes, Maite Garolera, Carme Junque
Summary: Patients with post-COVID-19 conditions often experience cognitive problems, with severe cases leading to long-term cognitive damage. This study aimed to clarify the relationship between COVID-19 severity and long-term cognitive outcomes, as well as determine if initial symptoms can predict long-term cognitive problems. Cognitive evaluations were conducted on healthy controls and post-COVID individuals categorized into severity groups. The severe group exhibited significant deficits in executive function, and several initial symptoms predicted long-term sequelae, suggesting the role of systemic inflammation and neuroinflammation in COVID-19's acute-phase symptoms.
JOURNAL OF NEUROLOGY
(2023)
Review
Immunology
Athanasios-Dimitrios Bakasis, Clio P. Mavragani, Kyriaki A. Boki, Athanasios G. Tzioufas, Panayiotis G. Vlachoyiannopoulos, Ioanna E. Stergiou, Fotini N. Skopouli, Haralampos M. Moutsopoulos
Summary: While most AARD patients experienced a mild course of COVID-19, certain underlying disease features and COVID-19 related manifestations should alert physicians to identify high-risk patients and the need for hospitalization.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Environmental Sciences
Roberta Pastorino, Angelo Maria Pezzullo, Leonardo Villani, Francesco Andrea Causio, Cathrine Axfors, Despina G. Contopoulos-Ioannidis, Stefania Boccia, John P. A. Ioannidis
Summary: This study found a substantial shift in the age distribution of COVID-19 deaths in countries that rapidly implemented vaccination predominantly among elderly, indicating the population-level effectiveness of COVID-19 vaccination and a favorable evolution of the pandemic towards endemicity with fewer elderly deaths.
ENVIRONMENTAL RESEARCH
(2022)
Article
Rheumatology
Tim Y. Koppert, Johannes W. G. Jacobs, Rinie Geenen
Summary: Patients with inflammatory rheumatic disease experienced higher levels of worry and stress during the peak of the COVID-19 pandemic, but their mental well-being was not reduced. Levels of psychological flexibility did not have a moderating effect on mental well-being.
Letter
Rheumatology
Pedro M. Machado, Martin Schaefer, Anja Strangfeld, Laure Gossec, Milena Gianfrancesco, Saskia Lawson-Tovey, Elsa F. Mateus, Loreto Carmona, Kimme L. Hyrich, Philip C. Robinson, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Kimme L. Hyrich, Martin Schaefer, Anja Strangfeld, Loreto Carmona, Laure Gossec, Elsa F. Mateus, Saskia Lawson-Tovey, Milena Gianfrancesco, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Article
Rheumatology
Manuel F. Ugarte-Gil, Graciela S. Alarcon, Andrea M. Seet, Zara Izadi, Anna D. Montgomery, Ali Duarte-Garcia, Emily L. Gilbert, Maria O. Valenzuela-Almada, Leanna Wise, Jeffrey A. Sparks, Tiffany Y. -T. Hsu, Kristin M. D'Silva, Naomi J. Patel, Emily Sirotich, Jean W. Liew, Jonathan S. Hausmann, Paul Sufka, Rebecca Grainger, Suleman Bhana, Zachary Wallace, Lindsay Jacobsohn, Anja Strangfeld, Elsa F. Mateus, Kimme L. Hyrich, Laure Gossec, Loreto Carmona, Saskia Lawson-Tovey, Lianne Kearsley-Fleet, Martin Schaefer, Pedro M. Machado, Philip C. Robinson, Milena Gianfrancesco, Jinoos Yazdany
Summary: A study on individuals with SLE in the US found that Black and Hispanic patients had higher odds of experiencing more severe COVID-19 outcomes compared to White patients, which may be attributed to socioeconomic and health disparities.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Hui Li, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Jie Wei, Dongxing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Yuqing Zhang
Summary: Patients with rheumatoid arthritis (RA) are at higher risks of SARS-CoV-2 infection and severe outcomes even after COVID-19 vaccination. It is necessary to implement booster COVID-19 vaccinations and other preventive strategies for patients with RA.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Laure Gossec, Stefan Siebert, Paul Bergmans, Kurt de Vlam, Elisa Gremese, Beatriz Joven-Ibanez, Tatiana Korotaeva, Frederic Lavie, Wim Noel, Michael T. Nurmohamed, Petros P. Sfikakis, Mohamed Sharaf, Elke Theander, Josef S. Smolen
Summary: This study evaluated the real-world persistence and effectiveness of the IL-12/23 inhibitor ustekinumab or a tumour necrosis factor inhibitor (TNFi) for psoriatic arthritis over 3 years. The results showed that the proportion of patients still on their initial treatments after 3 years was similar with ustekinumab and TNFi, but ustekinumab had a lower rate of adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Agnete Overgaard Donskov, Sarah Louise Mackie, Ellen Margrethe Hauge, Carlos Enrique Toro-Gutierrez, Ib Tonder Hansen, Andrea Katharina Hemmig, Aatke Van der Maas, Tamer Gheita, Berit Dalsgaard Nielsen, Karen M. J. Douglas, Richard Conway, Elena Rezus, Bhaskar Dasgupta, Sara Monti, Eric L. Matteson, Sebastian E. Sattui, Mark Matza, Vanessa Ocampo, Margarita Gromova, Rebecca Grainger, Andrea Bran, Simone Appenzeller, Annelise Goecke, Nelly Colman, Helen Keen, Masataka Kuwana, Latika Gupta, Babur Salim, Ghita Harifi, Mariam Erraoui, Nelly Ziade, Nizar Abdulateef Al-Ani, Adeola Ajibade, Johannes Knitza, Line Frolund, Max Yates, Victor R. Pimentel-Quiroz, Andre Marun Lyrio, Maria Sandovici, Kornelis S. M. Van der Geest, Toby Helliwell, Elisabeth Brouwer, Christian Dejaco, Kresten Krarup Keller
Summary: A global survey of general practitioners and rheumatologists revealed that a significant proportion of patients with polymyalgia rheumatica (PMR) are not referred for diagnosis or correctly managed, which has implications for clinical trial recruitment.
Article
Rheumatology
Katinka Albrecht, Anja Strangfeld, Ursula Marschall, Johanna Callhoff
Summary: This study investigates the prevalence, incidence, and medication of interstitial lung disease (ILD) among individuals with rheumatoid arthritis (RA) in Germany. It finds that RA-ILD is rare and mainly affects elderly individuals. Although there is no trend in incidence, treatment strategies have expanded, and specialist care is necessary to provide disease-specific therapies.
Article
Oncology
Beatriz Frade-Sosa, Chafik Alejandro Chacur, Josep M. Auge, Andres Ponce, Juan C. Sarmiento-Monroy, Ana Belen Azuaga, Nuria Sapena, Julio Ramirez, Virginia Ruiz-Esquide, Rosa Morla, Sandra Farietta, Patricia Corzo, Juan D. Canete, Raimon Sanmarti, Jose A. Gomez-Puerta
Summary: This study aimed to evaluate the serum levels of calprotectin in patients with rheumatic immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) treatment. The results showed that calprotectin can serve as a marker of inflammatory activity in patients with rheumatic irAEs.
Article
Rheumatology
Kaitlin R. McCarter, Taylor Wolfgang, Senada Arabelovic, Xiaosong Wang, Kazuki Yoshida, Emily P. Banasiak, Grace Qian, Emily N. Kowalski, Kathleen M. M. Vanni, Nicole R. LeBoeuf, Elizabeth Buchbinder, Lydia Gedmintas, Lindsey A. MacFarlane, Deepak A. Rao, Nancy A. Shadick, Ellen M. Gravallese, Jeffrey A. Sparks
Summary: Patients with pre-existing rheumatoid arthritis initiating immune checkpoint inhibitors had similar risk of mortality and severe immune-related AEs as matched comparators. Although patients with pre-existing rheumatoid arthritis were more likely to have immune-related AEs, this finding was mostly due to mild rheumatoid arthritis flares. These results suggest that this patient population can safely receive immune checkpoint inhibitors for cancer treatment.
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Amelie Nicolas, Sylvie Leroy, Luc Mouthon, Yurdagul Uzunhan, Vincent Cottin, Arsene Mekinian, Viviane Queyrel, Eric Hachulla, Benoit Gachet, David Launay, Nihal Martis
Summary: This study provides an overview of the diagnostic approaches, follow-up, and treatment strategies used in France for the management of SSc-associated ILD. The results highlight the heterogeneity and gaps in current clinical practices, calling for improvement and standardization.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Letter
Rheumatology
A. C. Duarte, A. Cordeiro, M. Lopes, J. Soares, M. J. Santos
Meeting Abstract
Rheumatology
Giovanni Zanframundo, Sara Faghihi-Kashani, Paul Hansen, Carlo A. Scire, Garifallia Sakellariou, Lorenzo Cavagna, Rohit Aggarwal
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)