Review
Pharmacology & Pharmacy
Most Afia Akhtar
Summary: This article reviews the use of traditional medicinal plants in Bangladesh for the treatment of inflammatory disorders and discusses their anti-inflammatory potential and future research directions. A total of 48 plant species have been reviewed, and the mechanisms, habitats, and anti-inflammatory studies conducted outside of Bangladesh are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Emir Muzurovic, Zoja Stankovic, Zlata Kovacevic, Benida Sahmanovic Skrijelj, Dimitri P. Mikhailidis
Summary: Diabetes mellitus is a chronic metabolic disorder that is also a significant cause of cardiovascular diseases. Inflammatory markers are associated with the risk of developing diabetes and its complications, but their practical use is limited by the intertwining of physiological processes and lack of specificity. Future research should focus on the specificity, non-invasiveness, and cost-effectiveness of biomarkers.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Pritika Mala, Gausal A. Khan, Romila Gopalan, Desta Gedefaw, Katy Soapi
Summary: Medicinal plants are natural sources of active compounds that have the potential to alleviate various illnesses, including diabetes. This study investigated the antidiabetic potential of Fijian medicinal plants and found that some of them showed significant inhibitory effects on enzymes linked to Type 2 diabetes.
BIOSCIENCE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Clement G. G. Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson, Bryan Mildort, Lekan Latinwo, Paul B. B. Tchounwou
Summary: Diabetes mellitus (DM) is a chronic metabolic disease associated with high blood sugar levels and various complications. Medicinal plants and vitamins have shown potential in the prevention and treatment of DM. This review article aims to study DM and explore the therapeutic modalities based on medicinal plants and vitamins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Lina T. Al Kury
Summary: Hyperglycemia, a hallmark of diabetes, can lead to various health complications. Medicinal plants offer bioactive compounds with pharmacological effects and fewer side effects. This review focuses on their modulation of the pancreatic K-ATP channel and emphasizes the importance of studying their interaction for diabetes treatment.
Article
Multidisciplinary Sciences
Simeon Omale, Kennedy I. Amagon, Titilayo O. Johnson, Shaun Kennedy Bremner, Gwyn W. Gould
Summary: Diabetes is a growing health emergency, causing economic burden and requiring more cost-effective therapies. This review explores the use of plant-based compounds in diabetes management, discussing their effects on insulin signaling pathways and providing evidence from both animal studies and clinical trials, suggesting their potential as novel therapeutics for diabetes.
Review
Pharmacology & Pharmacy
Arpita Das, Chiao-Ming Chen, Shu-Chi Mu, Shu-Hui Yang, Yu-Ming Ju, Sing-Chung Li
Summary: Edible mushrooms have various pharmaceutical properties that may help prevent diabetes and insulin resistance. However, there is a lack of in-depth research on the medicinal properties of many mushroom varieties, and further experimental and clinical studies are needed.
Article
Plant Sciences
Windmi Kagambega, Hadidjatou Belem, Roland Nag-Tiero Meda, Benjamin Kouliga Koama, Anne-Flora Drabo, Jacques Kabore, Amadou Traore, Georges Anicet Ouedraogo, Daniela Benedec, Daniela Hanganu, Laurian Vlase, Ana-Maria Vlase, Oliviu Vostinaru, Cristina Mogosan, Ilioara Oniga
Summary: The present study aimed to investigate the polyphenolic profile and anti-inflammatory and anti-nociceptive activities of four traditionally used medicinal plants from Burkina Faso. The results showed that these plants contained high levels of phenolic compounds and demonstrated significant inhibitory effects on inflammation and pain.
Review
Biochemistry & Molecular Biology
Alaa M. Abu-Odeh, Wamidh H. Talib
Summary: Diabetes is a global health problem, with the Middle East region showing interest in using traditional medicine and plant extracts to treat the disease. Studies have shown potential antidiabetic activity in plants, particularly those in the Asteraceae and Lamiaceae families, encouraging further research to confirm their medicinal value.
Review
Biochemistry & Molecular Biology
Mingyang Sun, Shiqiang Xu, Yu Mei, Jingyu Li, Yan Gu, Wenting Zhang, Jihua Wang
Summary: This review discusses the biosynthesis and function of medicinal plant miRNAs, including their regulation of animal gene expression and participation in plant metabolism, development, and stress adaptation. The research on medicinal plant miRNAs has its challenges, but it holds significant potential for drug development and agricultural production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lyudmila V. Nedosugova, Yuliya V. Markina, Leyla A. Bochkareva, Irina A. Kuzina, Nina A. Petunina, Irina Y. Yudina, Tatiana V. Kirichenko
Summary: The association between type 2 diabetes and cardiovascular complications is complex, primarily due to the oxidative stress and inflammation caused by hyperglycemia. Understanding the pathogenesis of type 2 diabetes and associated cardiovascular diseases can aid in the development of new diagnostic and therapeutic approaches.
Review
Pharmacology & Pharmacy
Gerardo Mata-Torres, Adolfo Andrade-Cetto, Fernanda Espinoza-Hernandez
Summary: The liver plays a crucial role in maintaining blood glucose levels by disposing, storing, and producing carbohydrates. Insulin regulates hepatic glucose production and storage, with dysfunction leading to hyperglycemia in obese or diabetic patients. Medicinal plants offer potential in improving hepatic glucose metabolism by inhibiting key enzymes and proteins, such as protein tyrosine phosphatase 1B, and regulating gluconeogenic pathways. Several plants, including Coreopsis tinctoria, Lithocarpus polystachyus, and Panax ginseng, show promise in developing herbal medicines targeting hepatic glucose output.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Hosna Khazaei, Mirko Pesce, Antonia Patruno, Ina Y. Aneva, Mohammad H. Farzaei
Summary: Diabetes and its complications are leading to increasing deaths, with neurological disorders being one of the most serious consequences. This study evaluated medicinal plants used for treating cognitive impairments and neurodegenerative diseases associated with diabetes from 2004 to 2020, finding that herbal medicine may be more effective due to the high antioxidant activity of some medicinal plants.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hira Zahoor, Kwanrutai Watchaputi, Janejira Hata, Wachirachai Pabuprapap, Apichart Suksamrarn, Lee Suan Chua, Nitnipa Soontorngun
Summary: There is a global demand for herbal extracts used in cosmetics, food, and health supplements. This study focuses on examining the antioxidant and anti-aging potential of flavonoids extracted from medicinal plants using Saccharomyces cerevisiae as a model organism. The results show that certain quercetin analogs can protect yeast cells against oxidative stress and extend the lifespan of wild-type S. cerevisiae.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Francisco Javier Aguirre Crespo, Elias Cerino Perez, Janice D. G. Valdovinos Estrella, Maria G. Maldonado Velazquez, Benjamin O. Ortega Morales, Pedro Zamora Crecencio, Emanuel Hernandez Nunez, Samuel E. Estrada Soto
Summary: Methanol leaf extracts of Brosimum alicastrum, Jatropha gaumeri, and Turnera diffusa exhibit high levels of simple phenolic and flavonoids compounds. J. gaumeri extract shows antioxidant and vasorelaxant activities, potentially linked to its content of gallic acid and quercetin. The interaction between gallic acid and quercetin improves the inhibition of beta-carotene bleaching, suggesting potential synergistic effects in lipophilic systems.
PHARMACOGNOSY MAGAZINE
(2021)
Review
Food Science & Technology
Ashraful Alam, Abdullah Al Arif Jahan, Md Sazzadul Bari, Labony Khandokar, Md Hasan Mahmud, Muhammed Junaid, Mohammed Salahuddin Chowdhury, Mohammad Forhad Khan, Veronique Seidel, Md Areeful Haque
Summary: This review provides an overview of the traditional uses, phytoconstituents, anti-inflammatory and anticancer activity of Allium species. These plants contain a wide range of chemical constituents and show potential for anti-inflammatory and anticancer effects. Garlic and onion, in particular, have been extensively studied, suggesting that other Allium species may also possess similar bioactive constituents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Plant Sciences
Ehfazul Haque, Md Sazzadul Bari, Labony Khandokar, Juhaer Anjum, Ibrahim Jantan, Veronique Seidel, Md Areeful Haque
Summary: This review provides a comprehensive update and analysis on the ethnomedicinal uses, phytochemistry, pharmacological activity, and toxicological profile of T. crispa. It summarizes the traditional uses of this plant in treating various diseases and discusses its potential in pharmaceutical research.
PHYTOCHEMISTRY REVIEWS
(2023)
Review
Biotechnology & Applied Microbiology
Gregorio Peron, Alice M. Lopez, Paulina Cabada-Aquirre, Karen D. Garay Buenrosto, Keila C. Ostos Mendoza, Gail B. Mahady, Veronique Seidel, Oksana Sytar, Niranjan Koirala, Roshani Gurung, Zenisha Acharya, Sundar Adhikari, Antoni Sureda, Miquel Martorell, Javad Sharifi-Rad
Summary: This article analyzes the antiviral and antibacterial capacity of phloroglucinols and their derivatives, indicating that these compounds have significant antimicrobial properties in vitro. However, the absence of in vivo studies and limited information on their mechanisms of action hinder their therapeutic use, requiring further research.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Faiza Riaz, Md. Sanower Hossain, Miah Roney, Yousaf Ali, Saira Qureshi, Riaz Muhammad, Said Moshawih, Shafida Abd Hamid, Veronique Seidel, Haroon Ur Rashid, Long Chiau Ming
Summary: Antimicrobial drug resistance poses a serious threat to global public health, and the discovery of new antibacterial agents is urgently needed. Quinoline derivatives have shown a range of pharmacological properties, including potential antibacterial effects. This study evaluated the binding affinity of three newly designed hydroxyquinoline compounds to multiple bacterial protein targets, and identified two compounds that may serve as new antibiotic scaffolds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Rana Mohammad Qasaymeh, Dino Rotondo, Veronique Seidel
Summary: This study identified the constituents of Fraxinus excelsior leaves and evaluated their effects on cell viability and the release of pro-inflammatory cytokines. The results showed that Fraxinus excelsior was able to reduce the production of pro-inflammatory cytokines.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Prawej Ansari, Sara S. Islam, Samia Akther, Joyeeta T. Khan, Jaber A. Shihab, Yasser H. A. Abdel-Wahab
Summary: The aim of this study was to investigate the insulinotropic and antidiabetic properties of ethanol extract of Acacia arabica (EEAA) bark through in vitro and in vivo studies. The results showed that EEAA significantly increased insulin secretion, regulated blood glucose levels, and improved insulin resistance. These findings suggest that EEAA has potential antidiabetic effects.
BIOSCIENCE REPORTS
(2023)
Review
Cell Biology
Javad Sharifi-Rad, Veronique Seidel, Michalak Izabela, Margalida Monserrat-Mequida, Antoni Sureda, Valeska Ormazabal, Felipe A. Zuniga, Shivaprasad Shetty Mangalpady, Raffaele Pezzani, Alibek Ydyrys, Gulmira Tussupbekova, Miquel Martorell, Daniela Calina, William C. Cho
Summary: Cancer is a leading cause of death worldwide, and its development is linked to oxidative stress. The transcription factor Nrf2 plays a vital role in protecting cells against oxidative stress in cancer growth, progression, and therapy resistance. Therefore, innovative inhibitors targeting Nrf2 are being investigated. This comprehensive review explores the potential of phenolic compounds, found in traditional plant-based remedies, as effective anticancer agents by inhibiting Nrf2. The clinical applications of naturally-occurring bioactive compounds as Nrf2 inhibitors, specifically polyphenols, are also discussed.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Oncology
Md Arman Islam, Maisha Maliha Medha, Akhlak Un Nahar, Md Abdullah Al Fahad, Md Afjalus Siraj, Veronique Seidel
Summary: The Keap1/Nrf2/ARE signaling pathway plays a critical role in regulating the cellular response to oxidative stress. This review focuses on the cancer protective role of 21 selected dietary polyphenols by modulating this signaling pathway and associated proteins. The majority of the studies demonstrate the cancer protective effects of these polyphenols mainly in-vitro, highlighting the need for further in-vivo studies and clinical trials to verify their effectiveness in humans.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Saud I. Al-Resayes, Fatima Y. Laria, Miloud M. Miloud, Marei M. El-ajaily, Najla M. El-Barasi, Ashish K. Sarangi, Sarika Verma, Mohammad Azam, Veronique Seidel, Ranjan K. Mohapatra
Summary: A series of mixed-ligand complexes of Fe(III), Cr(III), and La(III) were synthesized and characterized using various physicochemical techniques. The synthesized complexes exhibited an octahedral structure. The biological activity of these complexes was investigated against pathogenic bacterial strains and liver cancer cells.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Ranjan K. K. Mohapatra, Sarika Verma, Venkataramana Kandi, Ashish K. K. Sarangi, Veronique Seidel, Subrata Narayan Das, Ajit Behera, Hardeep Singh Tuli, Ashwani K. K. Sharma, Kuldeep Dhama
Summary: The Omicron variant is the fifth variant of concern of SARS-CoV-2, characterized by high mutation and contagiousness but low mortality. It shows resistance to antibodies generated by vaccination or prior infection, as well as monoclonal antibodies used for treatment. The importance lies in the need for booster doses and the development of more effective vaccines and treatments.
Review
Plant Sciences
Abhay Prakash Mishra, Pratichi Swetanshu, Pratichi Singh, Shikha Yadav, Manisha Nigam, Veronique Seidel, Celia Fortuna Rodrigues
Summary: Curcumin, a diarylheptanoid compound found in turmeric, has gained attention for its potential therapeutic effects in cancer. Various drug delivery approaches have been developed to optimize its pharmacokinetic profile and enhance its efficacy. Curcumin exhibits multiple biological activities, including anti-inflammatory, cardioprotective, antidiabetic, and anti-aging effects, and has been extensively studied for its role as a cancer chemopreventive and anticancer agent. This review focuses on curcumin's role in targeting cancer-related cell signaling pathways, including modulation of growth factors, transcription factors, kinases, enzymes, pro-inflammatory cytokines, and apoptotic proteins.
Review
Nutrition & Dietetics
Prawej Ansari, Jannatul F. Samia, Joyeeta T. Khan, Musfiqur R. Rafi, Md. Sifat Rahman, Akib B. Rahman, Yasser H. A. Abdel-Wahab, Veronique Seidel
Summary: Diabetes mellitus is a metabolic disorder characterized by high blood glucose levels due to defects in insulin release or action. It is a global health crisis with increasing prevalence. Although drugs are available for diabetes management, they have adverse side effects and are costly in underdeveloped countries. Traditional medicinal plants have been shown to possess antidiabetic activity and could be a potential alternative for managing diabetes. This article reviews the therapeutic effects, phytoconstituents, and molecular mechanisms of medicinal plant-based foods for diabetes management and suggests future research directions.
Article
Chemistry, Multidisciplinary
Hadjira Naoui, Mohamed Benalia, Soumaya Hachani, Amar Djeridane, Ziyad Ben Ahmed, Veronique Seidel, Mohamed Yousfi
Summary: Chemical characteristics, sterols, tocopherols, fatty acids profiles, and antioxidant activity of oils extracted from seven types of Ficus carica L. fruits from Algeria were investigated. The results showed that the figs oils had high acid values indicating a high amount of free fatty acids. The dominant lipid fraction in the oils was neutral lipids, followed by glycolipids and phospholipids. Linoleic and linolenic acids were the major unsaturated fatty acids, while palmitic acid was the major saturated fatty acid. The fig oils exhibited good antioxidant activity, which may be associated with their alleged health benefits.
CHEMISTRY JOURNAL OF MOLDOVA
(2023)
