期刊
FRONTIERS IN NUTRITION
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2022.877917
关键词
dietary selenium; kidney stones; National Health and Nutrition Examination Survey; calcium oxalate; Randall plaques
资金
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Fundamental Research Funds for the Central Universities of Central South University
- [82170781]
- [2021JJ31050]
- [2022ZZTS0294]
This study evaluated the association between dietary selenium intake and the risk of kidney stones in adults. The findings showed an inverse relation between dietary selenium intake and the risk of kidney stones, especially for younger individuals, males, and overweight/obese individuals. The study provides preliminary guidance on dietary selenium intake for the prevention of kidney stones in different populations.
PurposeTo evaluate the association between dietary selenium intake and the risk of kidney stones in adults. Materials and methodsWe performed a cross-sectional analysis using data from 2007 to 2018 National Health and Nutrition Examination Survey (NHANES). Dietary intake information of 30,184 participants was obtained using first 24-h dietary recall interview, and kidney stones were presented by a standard questionnaire. The quartile analysis, stratified analysis and non-linearity analysis were used to estimate the association between dietary selenium intake and kidney stones after an adjustment for potential confounders. ResultsThe multiple logistic regression indicated that the fourth quantile (Q4) of dietary selenium intake had a lower risk of kidney stones than the first quantile (Q1) in Model 3 (OR 0.82, P < 0.05). The stratified analyses indicated there were statistical differences between dietary selenium intake and kidney stones among younger (age < 50) (OR 0.65, P < 0.01), male (OR 0.73, P < 0.01) and overweight/obese (BMI >= 25.0) (OR 0.80, P < 0.05) individuals in Model 3. The non-linear relationship was founded between dietary selenium intake and kidney stones in all participants, younger, male and overweight/obese individuals after adjusting for confounding factors. ConclusionOur study revealed an inverse relation between the level of dietary selenium intake and the risk of kidney stones for the United States population, especially for younger (age < 50), male and overweight/obese (BMI >= 25.0) individuals. The study provides preliminary guidance on dietary selenium intake for the prevention of kidney stones in different populations. Further studies are required to confirm our findings and clarified the biological mechanisms.
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