Article
Gastroenterology & Hepatology
Lauren E. O'Connor, Jaime J. Gahche, Kirsten A. Herrick, Cindy D. Davis, Nancy Potischman, Ashley J. Vargas
Summary: The use of nonfood pre-, pro-, and synbiotic products has sharply increased in recent years, with one in 20 US adults or children using them. Most individuals voluntarily take these products for general digestive or overall health reasons.
Article
Food Science & Technology
Kariyawasam Majuwana Gamage Menaka Menike Kariyawam, Na-Kyoung Lee, Hyun-Dong Paik
Summary: This study aimed to develop a functional synbiotic yoghurt enriched with L. brevis KU200019 and FOS, which showed high antioxidant and immunomodulatory activities after storage. The supplementation of probiotics or FOS did not have adverse effects and could be used to improve the health benefits and quality of dairy products.
Article
Food Science & Technology
Ana Luiza Rocha Faria Duque, Fernanda Manaia Demarqui, Mariana Marchi Santoni, Cleslei Fernando Zanelli, Maria Angela Tallarico Adorno, Dragan Milenkovic, Victoria Mesa, Katia Sivieri
Summary: Imbalances in gut microbiota composition in individuals with ASD can be regulated by administering probiotics, prebiotics, and synbiotics, which have shown positive effects on gut microbiota and metabolic activity. Probiotic treatment increases the relative abundance of Lactobacillus, while prebiotic treatment increases Bifidobacterium and decreases Lachnoclostridium. Furthermore, changes in microbial metabolism, such as increased short-chain fatty acid concentrations and reduced ammonium levels, are associated with prebiotic and synbiotic treatments.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Microbiology
Carolina Szlufman, Moshe Shemesh
Summary: The human body harbors a variety of probiotic microorganisms that can positively affect physiology, with dietary fibers playing a crucial role in preserving probiotic efficacy and creating favorable conditions for probiotic colonization. Through prebiotic and synbiotic foods, these microorganisms can promote health in humans by stimulating various health characteristics. Additionally, the symbiotic interactions between probiotic Bacilli and prebiotic substances can serve as a novel platform for developing probiotic and synbiotic foods.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Fisheries
Juana Cristina del Valle, Maria Cecilia Bonadero, Analia Veronica Fernandez-Gimenez
Summary: Aquaculture is the fastest-growing food production area in the world. The use of probiotics, prebiotics, synbiotics, and parabiotics as alternatives to regular feed has been proven to improve the growth, immunity, and gut health of cultured species. Yeasts, particularly Saccharomyces cerevisiae, have shown health stimulating effects in various cultured species. However, the research on the application of S. cerevisiae in aquaculture has not been fully integrated, and this review aims to fill that gap and provide insights for future investigations.
Article
Food Science & Technology
Mei Zhi Alcine Chan, Shao-Quan Liu
Summary: The probiotic yeast Saccharomyces cerevisiae var. boulardii has gained attention in the field of functional food innovations. However, there is a lack of functional foods based on synbiotic or postbiotic preparations of S. boulardii, despite the potential improvements in shelf stability, sensorial properties, safety, and health benefits. This article explores the concepts of synbiotics and postbiotics with regards to S. boulardii, and examines the possibilities of adapting existing S. boulardii fortified food products into synbiotic and postbiotic formulations.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Pediatrics
Braden T. Tierney, James Versalovic, Alessio Fasano, Joseph F. Petrosino, Bruno P. Chumpitazi, Emeran A. Mayer, Jared Boetes, Gerard Smits, Shanthi G. Parkar, Noah Voreades, Ece Kartal, Gabriel A. Al-Ghalith, Marco Pane, Peter A. Bron, Gregor Reid, Raja Dhir, Christopher E. Mason
Summary: This study aimed to evaluate the efficacy of a synbiotic on increasing weekly bowel movements in constipated children. The results showed that treatment with the synbiotic increased the number of bowel movements in children with low baseline bowel movements, despite distinct baseline microbiome signatures. These findings suggest that multi-species synbiotic interventions may improve digestive health in pediatric population and that bioinformatics-based methods can predict response to microbial interventions in children.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, Research & Experimental
Chenyun Miao, Qingge Guo, Xiaojie Fang, Yun Chen, Ying Zhao, Qin Zhang
Summary: Probiotics and synbiotics seem to have a partially beneficial effect on indices of insulin resistance in patients with PCOS, with no significant impact on other indicators.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Food Science & Technology
Brenda Esmeralda Jimenez-Villeda, Reyna Nallely Falfan-Cortes, Esmeralda Rangel-Vargas, Eva Maria Santos-Lopez, Carlos Alberto Gomez-Aldapa, Ma. Refugio Torres-Vitela, Angelica Villarruel-Lopez, Javier Castro-Rosas
Summary: Probiotics are effective in assisting with human ailments, but they need to survive the gastrointestinal conditions before conferring their beneficial effects. Synbiotics, the combination of probiotics and prebiotics, can increase the beneficial effect, and microencapsulation is an efficient approach to protect synbiotics during their passage through the intestinal tract. This article thoroughly reviews the different encapsulation techniques of synbiotics and discusses the effect of microencapsulation on viability and probiotic properties in in vitro and in vivo models of microencapsulated synbiotics.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2023)
Review
Medicine, Research & Experimental
Ya Li, Tonghua Liu, Lingling Qin, Lili Wu
Summary: This study aimed to investigate the effects of probiotics on eight factors in overweight or obese children. Meta-analysis of four publications showed that probiotics significantly decreased levels of HDL-C, LDL-C, adiponectin, leptin, and TNF-α compared to placebo. However, there was no significant difference in BMI, TC, and TG between the two groups.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Food Science & Technology
A. Poshadri, H. W. Deshpande
Summary: The demand for non-dairy, thermostable synbiotic food is increasing. The food industry is promoting shelf-stable, non-dairy, and gluten-free alternatives that contain synbiotics, probiotics, and prebiotics for vegan, lactose-intolerant, and gluten-intolerant populations. This study investigated the properties of gluten-free vermicelli made from a blend of pseudocereals and compared it to wheat vermicelli. The addition of B. coagulans IS2 spores to the gluten-free vermicelli created synbiotic vermicelli with prebiotic properties.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
O. S. Fadare, V. Singh, O. I. Enabulele, O. H. Shittu, D. Pradhan
Summary: The study aimed to screen potential probiotic strains of Lactobacillus species for their synbiotic antibacterial action with garlic extract against Salmonella strains. L. plantarum NG6 was identified as the best probiotic lactobacilli, and the combination of garlic extract and Lactobacillus strains demonstrated synergistic antimicrobial action against Salmonella strains. This study suggests that probiotics can be combined with herbal preparations like garlic to combat gastrointestinal infections.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Estefania Valero-Cases, Maria Jose Frutos, Francisca Perez-Llamas
Summary: The study found that fermentation and inulin addition in mixed carrot-orange juice with Lactiplantibacillus plantarum (LP) can improve sensory profile and functional stability. The fermented drinks had high antioxidant capacity and were rich in bioactive compounds such as beta-carotene. Inulin helped maintain high LP concentration and positively influenced taste. Therefore, carrot-orange juice is a promising option for vegan probiotic delivery.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gonca Kilic Yildirim, Meltem Dinleyici, Yvan Vandenplas, Ener Cagri Dinleyici
Summary: This study is the first to demonstrate that the use of a multispecies synbiotic is associated with changes in intestinal microbiota composition and a decrease in BMI in children and adolescents with obesity.
Article
Microbiology
Jodi E. Nettleton, Teja Klancic, Alana Schick, Ashley C. Choo, Ning Cheng, Jane Shearer, Stephanie L. Borgland, Jong M. Rho, Raylene A. Reimer
Summary: The study showed that prebiotics and synbiotics can improve sociability, repetitive behavior, and gut health in a mouse model, while prebiotics may worsen sociability. Probiotic and symbiotic treatments also reduced intestinal permeability.
Review
Infectious Diseases
Edwin J. Asturias, Xilian Bai, Julie A. Bettinger, Ray Borrow, Delia Nais Castillo, Dominique A. Caugant, Grettel Chanto Chacon, Ener Cagri Dinleyici, Gabriela Echaniz-Aviles, Luis Garcia, Linda Glennie, Lee H. Harrison, Rebecca L. Howie, Mark Itsko, Jay Lucidarme, Jose Eduardo Oliva Marin, Henju Marjuki, Lucy A. McNamara, Mustapha M. Mustapha, Joan L. Robinson, Belkis Romeu, Manish Sadarangani, Xavier Saez-Llorens, Marco A. P. Safadi, David S. Stephens, James M. Stuart, Muhamed-Kheir Taha, Raymond S. W. Tsang, Julio Vazquez, Philippe De Wals
Summary: This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which focused on meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are monitored through passive and active surveillance networks. While IMD appears to be decreasing in many areas, there are regional variations and outbreaks among high-risk populations. Vaccination practices differ across North America, but overall vaccine uptake remains high.
JOURNAL OF INFECTION
(2022)
Article
Gastroenterology & Hepatology
Hania Szajewska, Roberto Berni Canani, Magnus Domellof, Alfredo Guarino, Iva Hojsak, Flavia Indrio, Andrea Lo Vecchio, Walter A. Mihatsch, Alexis Mosca, Rok Orel, Silvia Salvatore, Raanan Shamir, Chris H. P. van den Akker, Johannes B. van Goudoever, Yvan Vandenplas, Zvi Weizman
Summary: The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) provides updated recommendations for the use of probiotics for the management of selected pediatric gastrointestinal disorders. Specific probiotic strains are recommended for the treatment of acute gastroenteritis, prevention of antibiotic-associated diarrhea, nosocomial diarrhea and necrotizing enterocolitis, management of Helicobacter pylori infection, and management of functional abdominal pain disorders and infant colic. However, further studies are needed to confirm the effects and determine the type, dose, and timing of probiotics, and the use of probiotics without documented health benefits should be discouraged.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Pediatrics
Yalcin Kara, Mahmut Can Kizil, Omer Kilic, Tercan Us, Ener Cagri Dinleyici
Summary: This study evaluated the epidemiological and clinical features of pediatric patients whose gastrointestinal agents were detected by multiplex PCR. A total of 203 gastrointestinal pathogens were detected in the stool samples of 131 cases. The most common symptoms were diarrhea, fever, vomiting, and abdominal pain. The pathogen detection rate was 69% by multiplex PCR.
JOURNAL OF TROPICAL PEDIATRICS
(2022)
Article
Pediatrics
Sevgen Tanir Basaranoglu, Ayse Karaaslan, Enes Sali, Ergin Ciftci, Zeynep Gokce Gayretli Aydin, Bilge Aldemir Kocabas, Cemil Kaya, Semra Sen Bayturan, Soner Sertan Kara, Dilek Yilmaz Ciftdogan, Ummuhan Cay, Hacer Gundogdu Akturk, Melda Celik, Halil Ozdemir, Ayper Somer, Tijen Diri, Ahmet Sami Yazar, Murat Sutcu, Hasan Tezer, Eda Karadag Oncel, Manolya Kara, Solmaz Celebi, Aslinur Ozkaya Parlakay, Sabahat Karakaslilar, Emin Sami Arisoy, Gonul Tanir, Tugce Tural Kara, Ilker Devrim, Tugba Erat, Kubra Aykac, Ozge Kaba, Sirin Guven, Edanur Yesil, Ayse Tekin Yilmaz, Sevgi Yasar Durmus, Ilknur Caglar, Fatih Gunay, Metehan Ozen, Ener Cagri Dinleyici, Ates Kara
Summary: This study assessed the epidemiological data of pediatric patients with antibiotic-associated diarrhea in our region. The results showed that the prevalence of antibiotic-associated diarrhea was 10.4% for amoxicillin-clavulanate and 14.4% for cephalosporins. The occurrence of antibiotic-associated diarrhea differed significantly according to geographical regions in Turkey, particularly higher in The Eastern Anatolia and Southeastern Anatolia. This study provides epidemiological data and geographical differences for pediatric antibiotic-associated diarrhea.
Letter
Immunology
Mahmut Can Kizil, Yalcin Kara, Gurkan Bozan, Surhan Arda, Gul Durmaz, Omer Kilic, Ener Cagri Dinleyici
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Yalcin Kara, Mahmut Can Kizil, Mehmet Ozgur Arslanoglu, Ebru Kacmaz, Nidai Dalokay, Ezgi Pala, Eylem Kiral, Gurkan Bozan, Tercan Us, Omer Kilic, Ener Cagri Dinleyici
Summary: During the COVID-19 pandemic, pediatric cases of human bocavirus (HBoV) infection presented with severe respiratory symptoms, including common cold, acute otitis media, asthma exacerbations, and bronchiolitis pneumonia, and some cases required pediatric intensive care unit stay. A retrospective study evaluated the clinical characteristics of 54 children diagnosed with HBoV respiratory infections, revealing that cough, fever, and respiratory distress were the most prevalent symptoms, and a significant proportion of children required intensive care.
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Meltem Dinleyici, Jana Barbieur, Ener Cagri Dinleyici, Yvan Vandenplas
Summary: Human milk oligosaccharides (HMOs) are important components in human milk, varying greatly between mothers. HMOs improve gut health, protect against infection, and promote cognitive development. Supplementing formula with HMOs is safe and beneficial for microbiota composition and infection prevention, but the clinical benefits compared to non-human oligosaccharides are not known. More research is needed to understand the factors influencing HMO composition and their functions.
Article
Medicine, General & Internal
Gurkan Bozan, Vicente Perez-Brocal, Kaan Aslan, Eylem Kiral, Esra Sevketoglu, Mutlu Uysal Yazici, Ebru Azapagasi, Tanil Kendirli, Serhat Emeksiz, Oguz Dursun, Dincer Yildizdas, Ayse Berna Anil, Nihal Akcay, Hasan Serdar Kihtir, Merve Havan, Nazan Ulgen Tekerek, Faruk Ekinci, Omer Kilic, Andres Moya, Ener Cagri Dinleyici
Summary: The composition of microbiota in the intestines and nasopharynx of children with invasive meningococcal disease (IMD) was found to be different from that of healthy children. The infection itself or other care interventions led to changes in the microbiota composition. Understanding the interaction of microbiota with pathogens, such as N. meningitidis, could help us understand the dynamics of the disease.
Article
Pediatrics
Ayben Leblebici, Gurkan Bozan, Asli Kavaz Tufan, Eylem Kiral, Ebru Kacmaz, Ener Cagri Dinleyici
Summary: AKI in PICUs is a crucial factor affecting mortality in critically ill pediatric patients. This study compared the AKIN and pRIFLE AKI classifications and PICU scoring modalities, finding a significant correlation between AKI and PRISM III, PELOD-2, and pSOFA scores. However, there were no significant differences in the stages of kidney injury according to the AKIN criteria. Identifying the risk factors for AKI and planning antimicrobial regimens based on PICU admission could decrease mortality rates.
Article
Gastroenterology & Hepatology
Gonca Kilic Yildirim, Meltem Dinleyici, Yvan Vandenplas, Ener Cagri Dinleyici
Summary: This study is the first to demonstrate that the use of a multispecies synbiotic is associated with changes in intestinal microbiota composition and a decrease in BMI in children and adolescents with obesity.
Article
Microbiology
Gurkan Bozan, Yalcin Kara, Eylem Kiral, Mahmut Can Kizil, Ebru Kacmaz, Tercan Us, Gul Durmaz, Omer Kilic, Ener Cagri Dinleyici
Summary: This study evaluated the use of a rapid molecular diagnostic pneumonia panel in children with lower respiratory tract infections. The results showed that this approach has advantages in diagnosing pneumonia and guiding antibiotic therapy, as it provides results more quickly and enables the identification of resistance profiles.
Article
Microbiology
Pinar Yildiz, Melisa Sahin Tekin, Mucahit Kaya, Ener Cagri Dinleyici
Summary: The prevalence of Neisseria meningitidis carriage and serogroup distribution among older adults in Turkiye was assessed. The study found that 13.9% of participants carried Nm, with MenY being the most common serogroup. Only MenY was detected in patients over 75 years of age. Adequate surveillance and carriage studies can inform vaccination strategies for older adults.
Article
Pediatrics
Dilek Yilmaz, Gulnihan Ustundag, Ayse Buyukcam, Enes Sali, Umit Celik, Gulhadiye Avcu, Nursen Belet, Esra Cakmak Taskin, Sevliya Ocal Demir, Ahmet Ziya Birbilen, Omer Kilic, Ozge Metin Akcan, Ayse Tekin Yilmaz, Bilge Aldemir Kocabas, Nevin Hatipoglu, Adem Karbuz, Deniz Cakir, Murat Sutcu, Fatma Deniz Aygun, Taylan Celik, Semra Bayturan Sen, Nazan Dalgic, Zuhal Umit, Soner Sertan Kara, Eda Karadag Oncel, Ahmet Bolat, Merve Kilic Cil, Caner Turan, Ayse Cakil Guzin, Sevgi Topal, Gulser Esen Besli, Gizem Dogan, Sabiha Sahin, Fatih Akin, Yasar Bildirici, Gulperi Timurtas Dayar, Emine Ergul Sari, Didem Kizmaz Isancli, Manolya Kara, Pinar Onal, Hakan Aylac, Duygu Luleci, Belma Yasar, Elif Dede, Aykut Caglar, Sevgi Akova, Elif Afat Turgut, Pinar Yazici Ozkaya, Tugba Kandemir Gulmez, Emel Ulusoy, Muhterem Duyu, Yalcin Kara, Huseyin Celiktas, Onur Tekeli, Fatma Caglar, Doruk Gul, Sinem Oral Cebeci, Fatih Battal, Alkan Bal, Emre Aygun, Metin Uysalol, Gazi Arslan, Ayberk Ozkavakli, Mahmut Can Kizil, Abdullah Yazar, Fatih Aygun, Ayper Somer, Necdet Kuyucu, Ener Cagri Dinleyici, Ates Kara
Summary: This is a multi-center point prevalence study on children diagnosed with coronavirus disease 2019 (COVID-19). The study included inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 12 cities and 24 centers in Turkey on February 2nd, 2022. Among 8605 patients in participating centers on that day, 706 (8.2%) had COVID-19. The study found that fever, cough, and fatigue were the most common symptoms of COVID-19 in children, and asthma, neurologic disorders, and obesity were the most common underlying chronic diseases. The vaccination rate for COVID-19 was 12.5%.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Meeting Abstract
Critical Care Medicine
E. Kiral, O. Kilic, G. Bozan, E. Kacmaz, Y. Kara, M. C. Kizil, G. Durmaz, E. C. Dinleyici
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Correction
Pediatrics
Cansu Suskun, Omer Kilic, Dilek Yilmaz Ciftdogan, Sirin Guven, Adem Karbuz, Aslinur Ozkaya Parlakay, Yalcin Kara, Ebru Kacmaz, Aslihan Sahin, Aysun Boga, Didem Kizmaz Isancli, Belgin Gulhan, Saliha Kanik-Yuksek, Eylem Kiral, Gurkan Bozan, Mehmet Ozgur Arslanoglu, Mahmut Can Kizil, Meltem Dinleyici, Tercan Us, Ahmet Varis, Mucahit Kaya, Yvan Vandenplas, Ener Cagri Dinleyici
EUROPEAN JOURNAL OF PEDIATRICS
(2022)