Article
Medicine, Research & Experimental
Wei Liu, Dunwei Wang, Lidi Liu, Lin Wang, Ming Yan
Summary: The study revealed the important role of miR-140 in osteosarcoma development, inhibiting tumor cell proliferation, migration, and invasion, as well as promoting cell apoptosis by targeting USP22.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Jian Li, Zhuangzhuang Wu, Jiani Wang, Taiyong Wu, Zhen Shen, Long Zhang, Jia Lv, Junjun Bai, Yi Feng
Summary: MiR-200c acts as a tumor suppressor in osteosarcoma (OS) and the regulatory pathway protein NDN may play a role in inhibiting OS progression. Upregulating miR-200c suppresses cell proliferation, invasion, and metastasis, promotes apoptosis, and inhibits tumor growth. The correlation between miR-200c and NDN suggests theirpotential as targets for OS treatment.
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Jianzhong Wu, Ling Gao, Hong Chen, Xiaojun Zhou, Xialiang Lu, Zhongqi Mao
Summary: This study revealed that in poorly differentiated gastric cancer (PDGC), the upregulation of LINC02535 expression contributes to cell proliferation, migration, invasion, and wound healing, while its inhibition facilitates cell apoptosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Cell Biology
Lu Ding, Rongxin Sun, Qi Yan, Chengwei Wang, Xiaoping Han, Yong Cui, Rong Li, Jiwen Liu
Summary: In osteosarcoma, miR-506 directly targets Skp2 to inhibit cell proliferation, induce apoptosis, and reduce migration and invasion abilities. Upregulation of Skp2 reverses the tumor suppressive effects of miR-506, while downregulation of Skp2 enhances the anticancer activity of miR-506 mimic transfection in osteosarcoma cells.
Article
Biotechnology & Applied Microbiology
Weiguo Wang, Yuezhan Li, Shuang Zhi, Jinsong Li, Jinglei Miao, Zhiyu Ding, Yi Peng, Yan Huang, Ruping Zheng, Haiyang Yu, Pei Qi, Jianlong Wang, Xingchang Fu, Minghua Hu, Shijie Chen
Summary: This study demonstrates that down-regulation of lncRNA-ROR or up-regulation of miR-185-3p inhibits osteosarcoma progression through the repression of YAP1.
Article
Oncology
Yong Li, Dai Song, Ting An, Jie Liu, Qian Yang, Shaokui Nan
Summary: miR-1226-3p was found to promote the proliferation of osteosarcoma cells, and it targeted TRAF3 in SaOS-2 cells.
Article
Oncology
Wacili Da, Lin Tao, Yue Zhu
Summary: This study demonstrates that CTAB inhibits the proliferation and metastasis of osteosarcoma cells, induces apoptosis through the PI3K/AKT signaling pathway, and does not inhibit the growth of human osteoblasts.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Angela De Luca, Daniele Bellavia, Lavinia Raimondi, Valeria Carina, Viviana Costa, Milena Fini, Gianluca Giavaresi
Summary: Resveratrol (RSV) exhibits multiple tumor-suppressing activities on osteosarcoma (OS) cell lines, including inhibition of cell growth, promotion of cell differentiation, inhibition of cell migration, and enhancement of cytotoxic effect in combination with chemotherapy.
Article
Medicine, General & Internal
Feng Gao, Feng Xu
Summary: This study analyzed the role of LncRNA GAL1 in osteosarcoma cancer proliferation, migration and invasion of cancer cells. The results showed that GASL1 exhibits lower expression in osteosarcoma tissues and cell lines than normal surroundings tissues and osteoblasts respectively. GASL1 overexpression resulted in a decline of cancer cell viability and decreased migration and invasion of cancer cells.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Guofeng Zhang, Yonglin Zhu, Chengzhen Jin, Qingpeng Shi, Xiaochun An, Licheng Song, Fengguang Gao, Shanhui Li
Summary: Circular RNA (circRNA) associated ceRNA network plays a critical role in the initiation and progression of osteosarcoma by upregulating CDK14 in a miR-330-3p-dependent manner.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Gastroenterology & Hepatology
Binbin Li, Yan Chu, Bing Yan, Xiaoli Ma, Duanrui Liu, Shanglin Wang, Yunshan Wang, Yanfei Jia
Summary: The reciprocal expression of DEC1 and DEC2 works together to sustain gastric cancer progression by promoting cell growth. DEC1 suppresses DEC2 expression by directly binding to the E-box of the DEC2 promoter, enabling further indirect or cooperative activation of additional downstream target genes.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Shu-fan Ji, Sheng-Lian Wen, Yu Sun, Pi-Wei Huang, Hao Wu, Mao-lin He
Summary: STIL is closely associated with the proliferation and invasion of osteosarcoma, and may promote the progression of osteosarcoma by regulating the expression of key genes such as CDK1, CCNB2, CDC20, CCNA2, BUB1, and AURKB.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yu Wen, Bin Li, Ming He, Songling Teng, Yuxiu Sun, Guangbin Wang
Summary: The study revealed that circHIPK3 was upregulated in osteosarcoma and promoted cell proliferation, migration, and invasion by sponging miR-637 to increase HDAC4 expression. This circHIPK3/miR-637/HDAC4 axis plays a crucial role in the progression of osteosarcoma.
Article
Developmental Biology
Joanna Smeeton, Natasha Natarajan, Arati Naveen Kumar, Tetsuto Miyashita, Pranidhi Baddam, Peter Fabian, Daniel Graf, J. Gage Crump
Summary: The study found that nkx3.2 mutant zebrafish exhibit cartilage overgrowth in place of missing jaw joints, as well as severe dysmorphologies of the facial skeleton, skullcap, and spine, revealing post-embryonic roles for Nkx3.2.