Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Cancer cell metabolism and the modulating effects of nitric oxide

(2015) Ching-Fang Chang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer

(2015) Vincenzo Bronte et al.   NATURE MEDICINE

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

(2015) Frank Szulzewsky et al.   PLoS One

Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway

(2015) Emeline Tabouret et al.   Oncotarget

The role of CXCR4 in highly malignant human gliomas biology: Current knowledge and future directions

(2014) Filippo Gagliardi et al.   GLIA

CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells

(2014) C Ieranò et al.   Cell Death & Disease

Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

(2013) E. Zajac et al.   BLOOD

Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia

(2013) Aleksandra Ellert-Miklaszewska et al.   GLIA

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cytokine Patterns in Brain Tumour Progression

(2013) Radu Albulescu et al.   MEDIATORS OF INFLAMMATION

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats

(2013) Shie-Chau Liu et al.   NEURO-ONCOLOGY

CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia

(2013) J. Lipfert et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases

(2013) Luigi Portella et al.   PLoS One

Radiation Therapy-Induced Tumor Invasiveness Is Associated with SDF-1-Regulated Macrophage Mobilization and Vasculogenesis

(2013) Shu-Chi Wang et al.   PLoS One

Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity

(2013) Monica Gatti et al.   TOXICOLOGY

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

CXCR4 Expression Predicts Patient Outcome and Recurrence Patterns after Hepatic Resection for Colorectal Liver Metastases

(2011) Adam C. Yopp et al.   ANNALS OF SURGICAL ONCOLOGY

Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas

(2011) D Tseng et al.   BRITISH JOURNAL OF CANCER

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

(2011) Konrad Gabrusiewicz et al.   PLoS One

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE