Article
Chemistry, Physical
Junjie Zhou, Xianbin Ma, Hao Li, Derun Chen, Liang Mao, Leilei Yang, Tian Zhang, Wei Qiu, Zhigang Xu, Zhi-Jun Sun
Summary: The study introduces a tumor-specific prodrug combining tanespimycin with chlorin e6 to induce pyroptosis in a targeted manner, enhancing the response to anti-PD-1 therapy and prolonging the survival of 4T1 breast tumor-bearing mice.
Article
Engineering, Biomedical
Yang Lu, Feng Xu, Yang Wang, Chao Shi, Yuzhuo Sha, Guangli He, Qichao Yao, Kun Shao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng
Summary: NBS-1MT, an organic photo-immune activator, effectively triggers pyroptosis and disrupts the suppressive tumor microenvironment, activating the immune response and inhibiting tumor growth.
Article
Engineering, Biomedical
Qing Xie, Zhen Li, Yang Liu, Dawei Zhang, Meng Su, Hiroaki Niitsu, Yuanyuan Lu, Robert J. Coffey, Mingfeng Bai
Summary: This study demonstrates the potential of TSPO-PDT as a successful therapeutic for CRC, with direct tumor growth suppression and the provocation of host anti-tumor immunity. The abscopal effect was observed in untreated tumors, highlighting the systemic effects of TSPO-PDT.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Physical
Qi Meng, Binbin Ding, Ping'an Ma, Jun Lin
Summary: Programmed cell death (PCD) and immunogenic cell death (ICD) are important mechanisms in cancer therapy, and understanding their relationship is significant for tumor treatments. This review describes the interrelationship between PCD and ICD using nanomedicines as examples. It provides an overview of PCD patterns, explores the link between apoptosis and ICD, introduces non-apoptotic signaling pathways and their relationship with ICD, and summarizes the potential application of PCD and ICD in the development of new nanomaterials. The review aims to deepen understanding, extend biomedical applications, and promote progress in clinical tumor therapy.
Article
Engineering, Biomedical
Qian Wang, Weiji Qin, Lei Qiao, Min Gao, Man Zhou, Huiru Zhang, Qiuting Sun, Wanqing Yao, Tianhao Yang, Xiaohe Ren, Gengyun Sun, Xiaoyan He
Summary: A photo-activated ROS amplifying system is developed to induce antitumor immune response and improve the efficacy of immunotherapy in cancer treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Feiyang Jin, Di Liu, Xiaoling Xu, Jiansong Ji, Yongzhong Du
Summary: With the rapid development of nanotechnology, photodynamic therapy is emerging as a novel non-invasive clinical treatment for specific cancers. Although induced cell death related to T cell-mediated antitumor immune responses through immunogenic cell death is promising, enhancing this immunogenic cell death for better efficacy remains a challenge.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Zhaoyun Liu, Xintong Xu, Kaining Liu, Jingtian Zhang, Dan Ding, Rong Fu
Summary: Although the treatment efficacy for hematological malignancies has improved, relapse or drug resistance remains a challenge. Microenvironment disorder plays a significant role in the pathogenesis of these malignancies. Immunogenic cell death (ICD) is a unique mechanism that triggers an adaptive immune response through danger signals or damage-associated molecular patterns, making it a potential immunotherapeutic approach for hematological malignancies. This review provides an overview of ICD induction in hematological malignancies and current research on combining ICD inducers with other treatment strategies.
Article
Engineering, Biomedical
Shenwu Zhang, Jing Wang, Zhiqiang Kong, Xinxin Sun, Zhonggui He, Bingjun Sun, Cong Luo, Jin Sun
Summary: Immunotherapy is a promising cancer treatment, but its efficacy for immune-cold tumors is not satisfactory. Photodynamic therapy can effectively induce immunogenic cell death, and the use of nanotechnology enhances the effectiveness of cancer immunotherapy. This article reviews recent advances in photodynamic therapy, nanotechnology, and immunogenic cell death, and discusses the prospects and challenges in this field.
Review
Oncology
Ting Wang, Wangrui Peng, Meng Du, Zhiyi Chen
Summary: Immunotherapy is a promising treatment for cancer, but its application is limited due to the suppression of tumor microenvironment and immune-related adverse events. Sonodynamic therapy (SDT) has been shown to effectively activate antitumor immunity and kill tumor cells. Various SDT therapies alone or in combination with other treatments have been developed to induce immunogenic cell death (ICD) and enhance immunotherapy. This paper provides an overview of the research progress in SDT and nanotechnology, discusses the strategies involving SDT alone, SDT-based synergistic induction of antitumor immunity, and SDT-based immunotherapy for multimodal immunotherapy. The prospects and challenges of SDT-based therapies in cancer immunotherapy are also discussed.
FRONTIERS IN ONCOLOGY
(2023)
Review
Immunology
Elena Catanzaro, Olivier Feron, Andre G. Skirtach, Dmitri V. Krysko
Summary: Immunogenic cell death (ICD) is an emerging therapeutic strategy in cancer immunotherapy, and nanomaterials can be used to enhance the immunogenicity of cancer cells killed by anti-cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Minji Choi, Jisoo Shin, Chae-Eun Lee, Joo-Yoon Chung, Minji Kim, Xiuwen Yan, Wen-Hao Yang, Jong-Ho Cha
Summary: Cancer immunotherapy has shown significant therapeutic effects on certain types of cancer, but has low response rates in most solid tumors. Combination therapies that enhance tumor immunogenicity, such as immunogenic cell death and T-cell therapies, are being considered as relevant therapeutic options.
Article
Biotechnology & Applied Microbiology
Ying Tian, Muhammad Rizwan Younis, Yuxia Tang, Xiang Liao, Gang He, Shouju Wang, Zhaogang Teng, Peng Huang, Longjiang Zhang, Guangming Lu
Summary: The study presented a compact and biocompatible platform using IR-780 loaded MPDA, showing high loading capacity, good solubility and stability, reduced toxicity, and efficient tumor accumulation. The combined PDT/PTT of IR-780@MPDA induced ICD, activating cytotoxic T cells for immunotherapeutic response to breast tumor and significantly suppressing tumor growth in vivo. The platform offered multimodal tumor theranostics with negligible systemic toxicity.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Editorial Material
Oncology
Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar
Summary: A new class of ruthenium-based photosensitizers have been discovered to induce potent cytotoxicity and immunogenic cell death in melanoma cells when activated by NIR light, potentially establishing protective antitumor immunity.
Article
Chemistry, Multidisciplinary
Shao-Zhe Wang, Yuxin Guo, Xinping Zhang, Hui-Heng Feng, Shun-Yu Wu, Ya-Xuan Zhu, Hao-Ran Jia, Qiu-Yi Duan, Shi-Jie Hao, Fu-Gen Wu
Summary: A mitochondria-targeting "mito-missile" is constructed, which can achieve targeted photodynamic therapy (PDT)/mild-temperature photothermal therapy (MTPTT) as well as immune cell death (ICD)-induced cancer immunotherapy. This study develops a dendrimer-based nanoplatform for realizing mitochondrion-acting PDT/MTPTT and mitochondrial stress-induced potentiated ICD, providing a guideline for designing effective ICD inducers in the future.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yan He, Shiyang Wu, Yibo Yuan, Yueci Sun, Qiangjuan Ai, Ruiqi Zhou, Guozhi Chai, Dawei Chen, Haiyang Hu
Summary: This study developed a novel nanoparticle to regulate tumor-associated fibroblasts and improve the efficacy of tumor immunotherapy. It was found that inhibiting tryptase secreted by mast cells can reduce the activation of tumor-associated fibroblasts and enhance the immunogenic cell death effect. Furthermore, this nanoparticle can remodel the immunosuppressive microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bingxin Gu, Xin Liu, Shuoer Wang, Xiaoping Xu, Xiaosheng Liu, Silong Hu, Wangjun Yan, Zhiguo Luo, Shaoli Song
Summary: This study evaluated the diagnostic value of [(68)Ga]Ga-DOTA-FAPI-04 PET/CT for recurrent soft tissue sarcoma (STS) and compared it with [F-18]FDG PET/CT. The results showed that [(68)Ga]Ga-DOTA-FAPI-04 PET/CT was more accurate than [F-18]FDG PET/CT in detecting recurrent lesions of liposarcoma, MSFT, and IDCS.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Hematology
Beibei Sun, Xiaoqian Ge, Xiao Li, Jianjian Zhang, Zizhou Zhao, Xiaosheng Liu, Yan Zhou, Jianrong Xu, Huilin Zhao, Jie Sun
Summary: This study evaluated the impact of diabetes on carotid plaque neovasculature as assessed by dynamic contrast-enhanced magnetic resonance imaging. The results showed that carotid plaques in patients with diabetes had higher K-trans values, indicating leaky plaque neovasculature. This leak was associated with hemoglobin A1c and may play a role in accelerated atherosclerosis progression in diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yves S. S. Kafuti, Shuang Zeng, Xiaosheng Liu, Jingjing Han, Ming Qian, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, Haidong Li
Summary: In this study, the fluorescent probe ER-Nap-NBD was developed to detect H2S levels in solution and living systems (cells and zebrafish) using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting.
CHEMICAL COMMUNICATIONS
(2023)
Review
Immunology
Xiaosheng Liu, Yuelun Zhang, Lianfeng Lu, Xiaodi Li, Yuanni Wu, Yang Yang, Taisheng Li, Wei Cao
Summary: According to a systematic review of 17 studies, high-dose intravenous immunoglobulin (IVIg) treatment for COVID-19 patients shows a potential benefit in reducing the risk of death, particularly for severe cases. However, there is no significant impact of IVIg compared to routine care on overall mortality, hospital stay duration, mechanical ventilation requirement, and incidence of adverse events among all hospitalized patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Liuwei Zhang, Jingyun Wang, Hongyan Cui, Haonan Zheng, Xiaolan Yin, Jiaqi Lin, Yue Wang, Yan Zhao, Haidong Li, Qixian Chen
Summary: Targeted therapy, inhibition of immune suppressive molecules, and the use of chemotherapy drugs can improve anti-tumor outcomes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Xiaodi Li, Ling Xu, Lianfeng Lu, Xiaosheng Liu, Yang Yang, Yuanni Wu, Yang Han, Xiaoxia Li, Yanling Li, Xiaojing Song, Wei Cao, Taisheng Li
Summary: This study evaluates the kinetics of HBsAg and the determinants of early HBsAg decline in HIV/HBV coinfected patients during cART. The results show that CD4(+) T cell levels, sPD-1 levels, and immune activation are closely related to the rate of HBsAg decline after cART initiation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiaosheng Liu, Weijun Wang, Hai Wu, Jiaren Chen, Xuan Zhang, Liming Zhang
Summary: The fill mining method is popular due to its advantages of high resource recovery rate, reliability and safety, and reduced surface tailings storage. However, the cemented fillings in fill mining exhibit similar properties to ultra-low strength plain concrete, resulting in issues such as high brittleness, low bending and tensile strength, and sudden failure. In this study, flexible grid reinforcement material was used and tests were carried out to compare the mechanical properties with and without the flexible grid. The results showed that the compressive strength of the flexible grid filling body increased with decreasing grid spacing, while the grid dimension had little effect on the compressive strength. The tensile and shear strength increased with increasing grid dimension and showed an optimal grid spacing. The macroscopic failure modes varied based on the test conducted, with shear failure observed in the compression test, tensile failure in the tensile test, and shear slip failure in the shear test. The experimental results provide guidance for mine filling by considering the strengthening coefficients of tensile strength, shear strength, cohesion, and internal friction angle.
APPLIED SCIENCES-BASEL
(2023)
Article
Immunology
Ling Xu, Li Zhang, Shuang Kang, Xiaodi Li, Lianfeng Lu, Xiaosheng Liu, Xiaojing Song, Yanling Li, Xiaoxia Li, Wei Lyu, Wei Cao, Zhengyin Liu, Taisheng Li
Summary: In this prospective study, PLWHs achieved protective antibody levels after HBV vaccine immunization, but cellular immunity and decline in HIV reservoir were suboptimal.
Article
Health Care Sciences & Services
Wei Cao, Xiaosheng Liu, Yang Han, Xiaojing Song, Lianfeng Lu, Xiaodi Li, Ling Lin, Lijun Sun, An Liu, Hongxin Zhao, Ning Han, Hongxia Wei, Jian Cheng, Biao Zhu, Min Wang, Ying Li, Ping Ma, Liying Gao, Xicheng Wang, Jianhua Yu, Ting Zhu, Jean-Pierre Routy, Min Zuo, Taisheng Li
Summary: This study evaluated the efficacy of the Chinese herbal derivative LLDT-8 in HIV-suppressed immunological non-responders. The results showed that LLDT-8 was well-tolerated and effective in inhibiting viral replication and improving CD4 T cell counts. It provides a potential therapeutic option for long-term suppressed INRs.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Nanoscience & Nanotechnology
Liuwei Zhang, Haonan Zheng, Hongyan Cui, Xiaolan Yin, Cheng Zhang, Yue Wang, Yan Zhao, Jiaqi Lin, Zheng Wang, Jingyun Wang, Qixian Chen
Summary: One challenge in antitumor therapy is delivering the therapeutic agent precisely to cancerous cells. This study developed a redox-responsive polymeric dual-prodrug nanocarrier that could activate and release cytotoxic chemotherapy drugs and an immune checkpoint inhibitor simultaneously within tumor cells, resulting in significant cytotoxicity. This dual-prodrug delivery system shows great potential in chemotherapy and immunotherapy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Liuwei Zhang, Jingyun Wang, Hongyan Cui, Haonan Zheng, Xiaolan Yin, Jiaqi Lin, Yue Wang, Yan Zhao, Haidong Li, Qixian Chen
Summary: Tumors that can escape immune clearance can be effectively treated by a chemotherapeutic nanomedicine that targets the tumors and delivers siRNA payloads to knock down immune suppressive molecules, resulting in the reactivation of anti-tumor immunities. This study demonstrated significant anti-tumor effects in triple-negative breast tumors by using a chemotherapeutic nanomedicine that combines targeted delivery and RNA interference.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Lianfeng Lu, Yang Yang, Zhangong Yang, Yuanni Wu, Xiaosheng Liu, Xiaodi Li, Ling Chen, Yang Han, Xiaojing Song, Ziqing Kong, Wei Cao, Taisheng Li
Summary: Significant metabolic changes were observed in HIV-infected individuals before and after ART treatment, regardless of their immunological recovery status. The disturbed profiles of lipids and nucleotides in HIV infection did not return to normal levels even after long-term ART, and were correlated with modified cytokines and biomarkers of chronic non-AIDS events, suggesting the need for interventions beyond ART.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)