Article
Pharmacology & Pharmacy
Ye Gu, Yu-Tung Lai, Fang-Rong Chang, Chung-Yu Chen
Summary: This study evaluated patterns of traditional Chinese medicine (TCM) utilization and clinical features in IBS patients in Taiwan. The findings showed that females were more likely to use TCM for IBS than males. Chinese herbal medicine (CHM) was the most commonly used TCM modality, with Jia-wei-xiao-yao-san being the most frequently prescribed Chinese herbal formula and Bai-zhu being the most frequently prescribed single Chinese herb.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yoshiyuki Mishima, Shunji Ishihara
Summary: Irritable bowel syndrome (IBS) is a chronic functional disorder affecting the gastrointestinal tract, with the dysregulation of the brain-gut-microbiome (BGM) axis potentially playing a major role in its pathogenesis. Serotonin is a key neurotransmitter involved in IBS pathology, and genome studies have identified susceptible genes. Treatment strategies targeting 5-HT have shown effectiveness in certain IBS cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Emeran A. Mayer, Hyo Jin Ryu, Ravi R. Bhatt
Summary: Irritable bowel syndrome (IBS) is a prevalent disorder of brain-gut interactions, affecting 5-10% of the global population. The current diagnosis criteria focus on recurrent abdominal pain and altered bowel habits, but patients also experience non-painful abdominal discomfort, psychiatric conditions, and other pain-related symptoms. Recent research has revealed a comprehensive disease model of brain-gut-microbiome interactions, explaining the various symptoms of IBS. This model incorporates the gut connectome, enteric nervous system, brain alterations, and correlations with genetic, gastrointestinal, immune, and gut microbiome-related factors.
MOLECULAR PSYCHIATRY
(2023)
Review
Chemistry, Medicinal
Atefeh Jalali, Negar Firouzabadi, Mohammad M. Zarshenas
Summary: Depression is a common mental disorder worldwide, with genetic factors and bioactive compounds in medicinal plants being linked to its treatment outcomes. Traditional Persian medicine manuscripts provide various anti-depressant remedies, which may offer new insights into depression prevention and management when combined with genetics science.
PHYTOTHERAPY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Ghazaleh Mosleh, Parmis Badr, Meysam Zaeri, Abdolali Mohagheghzadeh
Summary: Traditional Persian Medicine (TPM) recommends potential functional foods (FFs) for managing the global pandemic of COVID-19. Through searching traditional Persian pharmacopoeia and academic literature, 12 TPM FFs were found with pharmacological mechanisms including antiviral, anti-inflammatory, and antioxidant effects. These FFs could serve as cost-effective, easily accessible, and safe options for both treatment and prevention of COVID-19.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Si-qi Tang, Yun-liang Wang, Zi-ye Xie, Yang Zhang, Yi Guo, Kang-li Gao, Tang-you Mao, Chun-e Xie, Jun-xiang Li, Xiao-yan Gao
Summary: This study revealed through serum metabolomics that different TCM syndrome types in IBS-D may exhibit distinct metabolic patterns, with glycerophospholipid metabolism being a significant pathway affected differently among the three TCM syndromes.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Review
Pharmacology & Pharmacy
Hyejin Jun, Seok-Jae Ko, Keumji Kim, Jinsung Kim, Jae-Woo Park
Summary: This study assessed the methodology and quality of evidence of systematic reviews (SRs) on the use of herbal medicines (HMs) for irritable bowel syndrome (IBS). The findings suggest that HM can be considered as an effective and safe treatment for IBS. However, the methodological quality of the included SRs and the quality of evidence were generally low. Well-designed randomized controlled trials are needed to better evaluate the safety and efficacy of HM in IBS treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Weina Qian, Weili Li, Xiaoyang Chen, Lingwen Cui, Xiangning Liu, Junkai Yao, Xiaoping Wang, Yizhou Liu, Chun Li, Yong Wang, Wei Wang
Summary: This study investigated the efficacy of Xingpi Capsule (XP) in treating diarrhea-predominant irritable bowel syndrome (IBS-D) and elucidated the underlying molecular mechanisms. The results showed that XP displayed multifaceted protection against IBS-D in rats by regulating the intestinal microbiota, increasing the relative expression level of HPX, a metabolite of the microbiota, and inhibiting the ASK1/P38 MAPK signaling pathway.
Article
Gastroenterology & Hepatology
Tarkan Karakan, Aycan Gundogdu, Hakan Alagozlu, Nergiz Ekmen, Seckin Ozgul, Varol Tunali, Mehmet Hora, Damla Beyazgul, O. Ufuk Nalbantoglu
Summary: AI-based personalized microbiome modulation through diet significantly improves IBS-related symptoms in patients with IBS-M. The personalized nutrition group showed more significant changes in IBS-SSS scores and improvement in gut microbiome features compared to the standard IBS diet group.
Review
Pharmacology & Pharmacy
Shuo Yuan, You Li, Jiao Li, Jia-Chen Xue, Qi Wang, Xiao-Ting Hou, Huan Meng, Ji-Xing Nan, Qing-Gao Zhang
Summary: This paper provides a scientific and theoretical basis for the treatment of IBD by reviewing the mechanism and research status of traditional Chinese medicine and natural products in IBD treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Huynh Nguyen Loc, Truong Thi Ngoc Lan, Dinh Thi Lan Huong, Nguyen Thanh Tuyen, Tran Minh Quang, Ly Minh Dao, Pham Hung Van, Nguyen Lam Vuong
Summary: Kovir capsule, developed from Ren Shen Bai Du San formulation, has been found to be safe and effective in improving symptom resolution in mild COVID-19 patients. Further large-scale trials are needed to confirm these findings.
PHYTOTHERAPY RESEARCH
(2022)
Review
Integrative & Complementary Medicine
Guan-ru Chen, Xiao-fang Xie, Cheng Peng
Summary: Irritable bowel syndrome (IBS) is a common and difficult-to-treat disease, and Chinese medicine has shown remarkable efficacy and advantages in its treatment. This review summarizes the literature on the treatment of IBS with Chinese medicine, highlighting the latest treatment methods and underlying mechanisms. The primary methods of Chinese medicine treatment for IBS are herbal prescriptions, acupuncture, and moxibustion, with potential mechanisms involving the regulation of the enteric nervous system, alleviation of visceral hypersensitivity, stability of intestinal flora, and regulation of the immune system.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Medicine, General & Internal
Jun Zhao, Min Chen, Xin Wang, Kun Ye, Suhua Shi, Huixia Li, Jianfang Wang, Xiaowei Chen, Jinxia Ni, Qingshuang Wei, Yunzhou Shi, Yu Hu, Jingwen Sun, Da Li, Siyuan Liu, Zhigang Li, Hui Zheng, Shu-guang Yu
Summary: This study aims to investigate the efficacy and safety of acupuncture therapy for refractory IBS. Randomly assigned patients will receive either acupuncture or sham acupuncture, and outcomes will be compared to evaluate the effectiveness of acupuncture treatment.
Review
Gastroenterology & Hepatology
Stuart M. Brierley, Beverley Greenwood-Van Meerveld, Giovanni Sarnelli, Keith A. Sharkey, Martin Storr, Jan Tack
Summary: This review provides an overview of the potential of the gastrointestinal endocannabinoid system as a therapeutic target for the management of pain in irritable bowel syndrome. It discusses the role of endocannabinoid system in regulating gastrointestinal function and pain processing, compares cannabinoids to other treatment modalities, and explores emerging therapeutic candidates targeting the endocannabinoid system for pain relief in irritable bowel syndrome.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hui Zheng, Song Jin, Yin-Li Shen, Wen-Yan Peng, Kun Ye, Tai-Chun Tang, Jun Zhao, Min Chen, Zhi-Gang Li
Summary: This study found that Chinese herbal medicine is effective in relieving IBS symptoms but may cause a higher rate of adverse events compared to placebo. The findings were confirmed through trial sequential analysis with sufficient information size.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rehabilitation
Saeed Shahabi, Parviz Mojgani, Masoud Behzadifar, Reza Tabrizi, Seyed Taghi Heydari, Kamran Bagheri Lankarani
Summary: The physiotherapy sector in Iran has faced various challenges after the implementation of the Health Transformation Plan, including issues related to financing, payment, behaviors, organization, and regulation. Enhancing policymakers' awareness and aligning health reforms such as the HTP with current documents can help reduce these challenges.
DISABILITY AND REHABILITATION
(2022)
Article
Rehabilitation
Saeed Shahabi, Dimitrios Skempes, Parviz Mojgani, Kamran Bagheri Lankarani, Seyed Taghi Heydari
Summary: This study investigates the common pitfalls and potential policy solutions to improve the stewardship of physiotherapy services in Iran from the perspective of key stakeholders. Participants identified several challenges across various dimensions of stewardship and suggested policy options to address critical deficiencies in the system. Insights from participants can inform decision-making processes to support the development, expansion, and implementation of physiotherapy services.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Article
Multidisciplinary Sciences
Sulmaz Ghahramani, Navid Omidifar, Saghar Garayemi, Mohammad Sayari, Kamran Bagheri Lankarani
Summary: This study evaluated the prevalence of burnout in hospital staff in southwest Iran and emphasized the importance of individual factors in their work life. The findings revealed that emotional exhaustion and depersonalization were common among the staff, and factors such as considering job change and work experience were associated with burnout.
Article
Public, Environmental & Occupational Health
Kamran Bagheri Lankarani, Camellia Hemyari, Behnam Honarvar, Elahe Khaksar, Fatemeh Shaygani, Mohammad Reza Rahmanian Haghighi, Mohammad Reza Shaygani
Summary: This study investigates the rate of change in domestic violence (DV) and its associated factors during the COVID-19 epidemic in Shiraz, Iran. The study finds that the occurrence of DV increased by 37.5% during the quarantine period, and factors such as COVID-19 infection, drug use, strict observation of anti-COVID prevention protocols, and low physical activity during quarantine are significantly associated with the occurrence of DV.
Review
Pharmacology & Pharmacy
Zohre Montaseri, Samira Sadat Abolmaali, Ali Mohammad Tamaddon, Fakhrossadat Farvadi
Summary: Cartilage tissue engineering requires an appropriate microenvironment for chondrocyte proliferation. Composite silk fibroin hydrogels have shown strong potential and advantages for cartilage regeneration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Integrative & Complementary Medicine
Maryam Azimi, Mohammad Javad Zahedi, Mahboobeh Raeiszadeh, Aida Iraji, Holger Cramer, Mehdi Pasalar
Summary: This clinical trial compared the effects of Celery and Ajwain with Domperidone for the treatment of postprandial distress syndrome. The results showed that patients who received Celery and Ajwain had lower symptom severity and higher quality of life. Therefore, this herbal mixture can be considered as a safe and effective remedy.
COMPLEMENTARY MEDICINE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Mana Heidari, Mohsen Salmanpour, Haniyeh Najafi, Maryam Monajati, Zahra Rahiminezhad, Negar Azarpira, Samira Sadat Abolmaali, Ali Mohammad Tamaddon
Summary: Over-expression of miR21a is shown to drive cancer progression by promoting cancer cell proliferation, migration, invasion, and metastasis. In this study, a beta cyclodextrin-polyethyleneimine-graphene quantum dot (beta CD-PEI-GQD) nanocarrier was developed for efficient delivery of miR21a, leading to significant downregulation of miR21 expression levels.
Review
Dentistry, Oral Surgery & Medicine
Morteza Banakar, K. B. Lankarani, Mohebat Vali, Reza Tabrizi, Erfan Taherifard, Maryam Akbari
Summary: This study conducted a systematic meta-analysis to evaluate the effect of mass media campaigns on oral health knowledge. The results showed that these campaigns have positive effects, especially among the working-age population. However, more initiatives are needed to improve health knowledge among children, and the effects seem to be time-dependent and higher in shorter follow-up periods.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2023)
Review
Multidisciplinary Sciences
Shabnam Shahali, Saeed Shahabi, Manal Etemadi, Maryam Hedayati, Cornelia Anne Barth, Parviz Mojgani, Masoud Behzadifar, Kamran Bagheri Lankarani
Summary: This scoping review investigated the barriers and facilitators to integrating physiotherapy into primary health care. It found that poor knowledge of physicians about physiotherapy, ineffective teamwork, and physiotherapists' time constraints/workload were the most common barriers. Clarifying the role of involved professionals, strengthening teamwork, and improving intra-and inter-professional collaborations were suggested as important measures for facilitating the integration process.
Article
Multidisciplinary Sciences
Ali Mohammad Tamaddon, Rahman Bashiri, Haniyeh Najafi, Khadijeh Mousavi, Mahboobeh Jafari, Sedigheh Borandeh, Mahdokht H. Aghdaie, Mina Shafiee, Samira Sadat Abolmaali, Negar Azarpira
Summary: The cytotoxicity and genotoxicity of graphene oxide (GO) modified by different amino acids were evaluated. The results showed that the modified GO caused less cellular and genetic damage, with GO modified with aspartic acid exhibiting the lowest toxicity. This indicates the superior potential of modified GO in biomedical applications such as cell therapy and tissue engineering.
Article
Pediatrics
Najmeh Maharlouei, Arash Khojasteh Zonoozi, Zaynab Noeizad, Atila Erami, Hamidreza Parsa, Zahra Eskandari Kootahi, Sara Raji, Kamran B. Lankarani
Summary: This study investigates the prevalence, clinical characteristics, and outcomes of COVID-19 among neonates in Iran. The incidence of COVID-19 among neonates in Fars Province was found to be 47.5 per 100,000 living births in one year. Most neonates recovered, but there were also cases of mortality, with all deceased neonates having symptoms. Some neonates required admission to the neonatal intensive care unit (NICU).
INTERNATIONAL JOURNAL OF PEDIATRICS
(2023)
Article
Nanoscience & Nanotechnology
Zahra Janipour, Haniyeh Najafi, Samira Sadat Abolmaali, Reza Heidari, Negar Azarpira, Emine Dilek Ozyilmaz, Ali Mohammad Tamaddon
Summary: In this study, a peptide hydrogel containing SMV was designed and characterized. The results showed that the FmocFF-SMV hydrogel had fibrous structure and shear-thinning characteristics, leading to improved diabetic wound recovery and reduced inflammation.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mahboobeh Jafari, Samira Sadat Abolmaali, Sedigheh Borandeh, Haniyeh Najafi, Zahra Zareshahrabadi, Omid Koohi-Hosseinabadi, Negar Azarpira, Kamiar Zomorodian, Ali Mohammad Tamaddon
Summary: In this study, we successfully reduced the toxicity of amphotericin B (AMB) and improved its therapeutic efficacy by developing POSS-HPG@Chol/AMB nanostructures. These nanostructures provided complete protection against Candida infections in a mouse model and effectively reduced or eliminated AMB-induced liver and kidney injuries.
Article
Chemistry, Multidisciplinary
Mahboobeh Jafari, Samira Sadat Abolmaali, Sedigheh Borandeh, Haniyeh Najafi, Zahra Zareshahrabadi, Omid Koohi-Hosseinabadi, Negar Azarpira, Kamiar Zomorodian, Ali Mohammad Tamaddon
Summary: In this study, new polyhedral oligomeric silsesquioxane – hyperbranched polyglycerol dendrimers were developed to improve the safety and therapeutic efficacy of AMB. The synthesized dendrimers showed lower concentrations and toxicities against Candida spp. compared to conventional formulations, and they effectively protected mice from severe Candida infections and reduced organ injuries caused by AMB.
Article
Integrative & Complementary Medicine
Alireza Khosropanah, Mojgan Mehri Ardestani, Nematollah Rostami, Fatemeh Hashemi, Mehdi Pasalar, Jennifer Hunter, Ghazaleh Heydarirad
Summary: This study is the first to report the effects of using chicory and fumitory for the treatment of hot flashes in breast cancer survivors. The findings provide preliminary evidence that CFS can improve hot flashes in breast cancer survivors undergoing hormone deprivation therapy.
JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)