Synthesis of Novel Phthalazinedione-Based Derivatives with Promising Cytotoxic, Anti-bacterial, and Molecular Docking Studies as VEGFR2 Inhibitors

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations

(2021) Fathalla Khedr et al.   ARCHIV DER PHARMAZIE

Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches

(2021) Ahmed T.A. Boraei et al.   BIOORGANIC CHEMISTRY

Design, synthesis, docking, and anticancer evaluations of phthalazines as VEGFR‐2 inhibitors

(2021) Khaled El‐Adl et al.   ARCHIV DER PHARMAZIE

Design, synthesis and antiproliferative activity of new amine, amino acid and dipeptide-coupled benzamides as potential sigma-1 receptor

(2020) Eman Youssef et al.   Journal of the Iranian Chemical Society

Synthesis, characterization of some pyrazine derivatives as anti-cancer agents: In vitro and in Silico approaches

(2020) Eman S. Tantawy et al.   JOURNAL OF MOLECULAR STRUCTURE

Antimicrobial and antiproliferative activities of novel synthesized 6‐(quinolin‐2‐ylthio) pyridine derivatives with molecular docking study as multi‐targeted JAK2/STAT3 inhibitors

(2020) Mohamed S. Nafie et al.   Chemical Biology & Drug Design

Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells

(2020) Mohamed S. Nafie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Convenient Synthesis and Anticancer Activity of Methyl 2-[3-(3-Phenyl-quinoxalin-2-ylsulfanyl)propanamido]alkanoates and N-Alkyl 3-((3-Phenyl-quinoxalin-2-yl)sulfanyl)propanamides

(2019) Samir M. El Rayes et al.   ACS Omega

Screening of different drug design tools to predict the mode of action of steroidal derivatives as anti-cancer agents

(2019) Mohamed S. Nafie et al.   STEROIDS

Eco-friendly one-pot synthesis of some new pyrazolo[1,2-b]phthalazinediones with antiproliferative efficacy on human hepatic cancer cell lines

(2018) Huda R. M. Rashdan et al.   Green Chemistry Letters and Reviews

Convenient Synthesis of Some Novel Pyridazinone-Bearing Triazole Moieties

(2018) Samir Mohamed El Rayes et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity

(2016) Kamilia M. Amin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

(2016) Sahar M. Abou-Seri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phthalazine-triones: Calix[4]arene-assisted synthesis using green solvents and their anticancer activities against human cancer cells

(2016) Yuri F. Rego et al.   Arabian Journal of Chemistry

Some Recent Approaches of Biologically Active Substituted Pyridazine and Phthalazine Drugs

(2012) M. Asif   CURRENT MEDICINAL CHEMISTRY

Convenient Synthesis and Antimicrobial Activity of Some Novel Amino Acid Coupled Triazoles

(2010) S. M. El Rayes   MOLECULES

Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines

(2007) Xin Zhai et al.   CHINESE CHEMICAL LETTERS