Air pollution, metabolites and respiratory health across the life-course

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

(2022) Alvar Agustí et al.   Lancet Respiratory Medicine

Metabolomic signatures of the long-term exposure to air pollution and temperature

(2021) Feiby L. Nassan et al.   Environmental Health

Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project

(2021) Shuo Liu et al.   EUROPEAN RESPIRATORY JOURNAL

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype

(2021) Daniela Rago et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hallmarks of environmental insults

(2021) Annette Peters et al.   CELL

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

(2021) Maria Michelle Papamichael et al.   Metabolites

Fine particulate matter exposure and perturbation of serum metabolome: A longitudinal study in Baoding, China

(2021) Shu Huan et al.   CHEMOSPHERE

Ambient PM2.5 species and ultrafine particle exposure and their differential metabolomic signatures

(2021) Feiby L. Nassan et al.   ENVIRONMENT INTERNATIONAL

Perturbation of amino acid metabolism mediates air pollution associated vascular dysfunction in healthy adults

(2021) Baihuan Feng et al.   ENVIRONMENTAL RESEARCH

Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma

(2021) Nima Afshar-Mohajer et al.   EUROPEAN RESPIRATORY JOURNAL

Global metabolome profiling of exhaled breath condensates in male smokers with asthma COPD overlap and prediction of the disease

(2021) Nilanjana Ghosh et al.   Scientific Reports

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

(2021) Pei Zhang et al.   Environmental Science & Technology Letters

Potential Metabolic Biomarkers in Adult Asthmatics

(2021) Soyoon Sim et al.   Metabolites

Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction

(2021) Audrey J. Gaskins et al.   ENVIRONMENT INTERNATIONAL

Metabolomic signatures of the short-term exposure to air pollution and temperature

(2021) Feiby L. Nassan et al.   ENVIRONMENTAL RESEARCH

Child serum metabolome and traffic-related air pollution exposure in pregnancy

(2021) Beate Ritz et al.   ENVIRONMENTAL RESEARCH

Clean air for healthy lungs – an urgent call to action: European Respiratory Society position on the launch of the WHO 2021 Air Quality Guidelines

(2021) Zorana Jovanovic Andersen et al.   EUROPEAN RESPIRATORY JOURNAL

Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study

(2021) Stacey N. Reinke et al.   EUROPEAN RESPIRATORY JOURNAL

Dynamic molecular choreography induced by traffic exposure: A randomized, crossover trial using multi-omics profiling

(2021) Xihao Du et al.   JOURNAL OF HAZARDOUS MATERIALS

The role of gene–environment interactions in lung disease: the urgent need for the exposome

(2020) Craig E. Wheelock et al.   EUROPEAN RESPIRATORY JOURNAL

Long-term effects of air pollution: an exposome meet-in-the-middle approach

(2020) Paolo Vineis et al.   International Journal of Public Health

The exposome and health: Where chemistry meets biology

(2020) Roel Vermeulen et al.   SCIENCE

Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in lymphangioleiomyomatosis

(2020) Leonardo Bottolo et al.   THORAX

Asthma genetics revisited: understanding disease mechanisms by studying ethnically diverse groups

(2020) Erik Melén   Lancet Respiratory Medicine

Identifying Protein–metabolite Networks Associated with COPD Phenotypes

(2020) Emily Mastej et al.   Metabolites

Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study

(2020) Ikenna C. Eze et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

(2020) Ivana Prokić et al.   BMC Pulmonary Medicine

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

(2020) Matthew Moll et al.   Lancet Respiratory Medicine

Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure

(2020) Simon Kebede Merid et al.   ENVIRONMENT INTERNATIONAL

Metabolomics identifying biomarkers of PM2.5 exposure for vulnerable population: based on a prospective cohort study

(2020) Haiyan Chu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution

(2020) Zhenjiang Li et al.   ENVIRONMENTAL RESEARCH

Metabolomics in chronic lung diseases

(2019) Shabarinath Nambiar et al.   RESPIROLOGY

Environmental exposures and mechanisms in allergy and asthma development

(2019) Liza Bronner Murrison et al.   JOURNAL OF CLINICAL INVESTIGATION

Linking COPD epidemiology with pediatric asthma care; implications for the patient and the physician

(2019) Erik Melén et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Lung function trajectories in health and disease

(2019) Alvar Agusti et al.   Lancet Respiratory Medicine

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma

(2019) Donghai Liang et al.   ENVIRONMENT INTERNATIONAL

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

(2019) Olena Gruzieva et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Metabolomic signatures of asthma-COPD overlap (ACO) are different from asthma and COPD

(2019) Nilanjana Ghosh et al.   Metabolomics

The mediating effect of immune markers on the association between ambient air pollution and adult-onset asthma

(2019) Nahid Mostafavi et al.   Scientific Reports

Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma

(2019) Eitan Halper-Stromberg et al.   Metabolites

Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population

(2019) Bing Yu et al.   Metabolites

Urine metabolites associated with cardiovascular effects from exposure of size-fractioned particulate matter in a subway environment: A randomized crossover study

(2019) Yannan Zhang et al.   ENVIRONMENT INTERNATIONAL

An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma

(2018) Rachel S. Kelly et al.   CHEST

Increased urinary L-histidine in patients with asthma–COPD overlap: a pilot study

(2018) Jee Youn Oh et al.   International Journal of Chronic Obstructive Pulmonary Disease

Air pollution exposure and lung function until age 16 years: the PIAMA birth cohort study

(2018) Edith B. Milanzi et al.   EUROPEAN RESPIRATORY JOURNAL

Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD

(2018) Charmion I. Cruickshank-Quinn et al.   Scientific Reports

Linking sources to early effects by profiling urine metabolome of residents living near oil refineries and coal-fired power plants

(2017) Chi-Hsin Sally Chen et al.   ENVIRONMENT INTERNATIONAL

Oxidative stress and inflammation mediate the effect of air pollution on cardio- and cerebrovascular disease: A prospective study in nonsmokers

(2017) Giovanni Fiorito et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children

(2017) Olena Gruzieva et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The impact of ambient air pollution on the human blood metabolome

(2017) J.J. Vlaanderen et al.   ENVIRONMENTAL RESEARCH

Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015

(2017) Aaron J Cohen et al.   LANCET

Hippurate as a metabolomic marker of gut microbiome diversity: Modulation by diet and relationship to metabolic syndrome

(2017) Tess Pallister et al.   Scientific Reports

Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure

(2016) Olena Gruzieva et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Peptides in Bronchoalveolar Lavage in Chronic Obstructive Pulmonary Disease

(2016) Chris H. Wendt et al.   PLoS One

Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis

(2015) Chun Chang et al.   ACTA PHARMACOLOGICA SINICA

Circulating Levels of Antioxidant Vitamins Correlate with Better Lung Function and Reduced Exposure to Ambient Pollution

(2015) Cristina Menni et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

(2015) Peter Lange et al.   NEW ENGLAND JOURNAL OF MEDICINE

Causal mediation analysis with multiple mediators

(2014) R. M. Daniel et al.   BIOMETRICS

Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells

(2014) K. M. Hew et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Metabolomic markers reveal novel pathways of ageing and early development in human populations

(2013) Cristina Menni et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Meeting-in-the-middle using metabolic profiling – a strategy for the identification of intermediate biomarkers in cohort studies

(2010) Marc Chadeau-Hyam et al.   BIOMARKERS

1H Nuclear Magnetic Resonance Metabolomics Analysis Identifies Novel Urinary Biomarkers for Lung Function

(2010) Joseph L. McClay et al.   JOURNAL OF PROTEOME RESEARCH

Identification, Inference and Sensitivity Analysis for Causal Mediation Effects

(2010) Kosuke Imai et al.   STATISTICAL SCIENCE