Review
Dermatology
Anna Geueke, Catherin Niemann
Summary: Sebaceous glands play a critical role in skin homeostasis, with defects linked to various skin disorders. Recent research has made significant progress in understanding the mechanisms underlying sebaceous gland development, homeostasis, and disease formation.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Er-Yi Lin, Lang Rao, Wen-Ju Wang, Yong-Feng Chen
Summary: This study describes the imaging features of sebaceous gland hyperplasia (SGH) using dermoscopy and reflectance confocal microscopy (RCM), providing a non-invasive basis for accurate clinical diagnosis.
FRONTIERS IN MEDICINE
(2023)
Review
Immunology
Christos C. Zouboulis, Tom Coenye, Li He, Kenji Kabashima, Tetsuro Kobayashi, Catherin Niemann, Takashi Nomura, Attila Olah, Mauro Picardo, Sven R. Quist, Hironobu Sasano, Marlon R. Schneider, Daniel Torocsik, Sunny Y. Wong
Summary: This review presents the innovative concept of sebaceous immunobiology, discussing the physiological and pathophysiological tasks of sebaceous glands, the role of sebaceous lipids in the skin barrier function and innate immune processes, the connection between sebaceous glands and hair follicle morphogenesis, the involvement of inflammation in acne, the behavior of sebocytes as immune regulators, the regulation of sebaceous gland function by immune cells, the contribution of sebaceous glands to the immune response of perifollicular infiltrate, the role of inflammatory mediators and pattern recognition receptors in acne pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Koki Takamatsu, Junichi Tanaka, Ryogo Katada, Kotaro Azuma, Ikuko Takakura, Keiko Aota, Takaaki Kamatani, Tatsuo Shirota, Satoshi Inoue, Kenji Mishima
Summary: Research has shown a decline in the stem cell ability of CD133-positive stem/progenitor cells in the salivary glands of aged mice, with a decrease in the number of these cells and a lower sphere formation capacity compared to young and adult mice. CD133-positive cells in aged mice exhibited lower gene expression of aging-related genes than those in young and adult mice, indicating a potential role of FoxO3a in inhibiting stem cell aging via oxidative stress.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Katharina Klas, Dragan Copic, Martin Direder, Maria Laggner, Patricia Sandee Prucksamas, Florian Gruber, Hendrik Jan Ankersmit, Michael Mildner
Summary: Although sebocytes from sebaceous glands and preputial glands share common lipid-producing properties, significant differences were found in the expression levels of enzymes involved in the biogenesis of specialized lipid classes. This suggests major developmental, functional, and biosynthetic differences between the two gland types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Becky Massey, Natali Ronen, Nino Javakhishvili, Tamara Giorgadze
Summary: We present a case of sebaceous lymphadenoma, a rare benign salivary gland neoplasm, in a 74-year-old female. The preoperative diagnosis of sebaceous neoplasms can be challenging. This manuscript provides detailed information about the epidemiological characteristics, histogenesis, and cytomorphologic differential diagnosis of sebaceous salivary gland neoplasms, with a focus on sebaceous lymphadenoma.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Biology
Kohei Saeki, Gregory Chang, Noriko Kanaya, Xiwei Wu, Jinhui Wang, Lauren Bernal, Desiree Ha, Susan L. Neuhausen, Shiuan Chen
Summary: The study presents an integrated mammary cell gene expression atlas derived from mouse and human single-cell RNA-sequence data, characterizing key life stages of mammary gland remodeling and inferring cells of origin for various breast cancer subtypes using breast cancer expression data.
COMMUNICATIONS BIOLOGY
(2021)
Review
Medicine, General & Internal
Ilias Papadimitriou, Efstratios Vakirlis, Elena Sotiriou, Katerina Bakirtzi, Aimilios Lallas, Demetrios Ioannides
Summary: Sebaceous neoplasms are a group of tumors with sebaceous differentiation commonly found in the face and neck. Most of these tumors are benign, but malignant ones are rare. They are strongly associated with the Muir-Torre Syndrome. Patients suspected to have this syndrome should undergo neoplasm excision, followed by histopathologic and additional immunohistochemistry and genetics examinations.
Article
Oncology
Li Hu, Liming Su, Hainan Cheng, Chunling Mo, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Jianguang Zhang, Yuntao Xie
Summary: This study reveals that breast cancer in BRCA1 mutation carriers may originate from luminal cells and abnormal luminal progenitor cells in normal tissues may contribute to the development of basal-like tumors. Additionally, ERhigh luminal breast cancer may stem from mature luminal cells.
Review
Dermatology
A. Gan, A. Therianou
Summary: The literature review suggests that low-dose isotretinoin can safely and effectively treat acne in patients on renal dialysis, improving their quality of life. Although limited, more studies could help further establish the safety of isotretinoin in these patients.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Ophthalmology
A. C. Clemens, K. U. Loeffler, F. G. Holz, M. C. Herwig-Carl
Summary: Analysing surgically removed caruncular tumors over the past 22 years reveals a wide spectrum of mostly benign tumors, with oncocytomas and malignant lesions mainly occurring in patients over 60 years old. Clinical diagnosis was confirmed in only 68.3% cases, highlighting the importance of detailed histopathological examination for accurate diagnosis and management of potentially malignant caruncular lesions.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biology
Leonard Herault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Elisabeth Remy, Estelle Duprez
Summary: By analyzing 15,000 young and aged HSC transcriptomes, the study identified 15 groups of HSCs showing rare and new specific abilities that change with age. This established a new reference map of HSC differentiation and revealed a potential mechanism that delays differentiation in aged HSCs, potentially contributing to age-related hematologic diseases.
Review
Dermatology
Lama Hussein, Conal M. Perrett
Summary: Our findings show that the literature is categorized according to the treatment modalities ranging from conventional techniques such as oral isotretinoin and cryotherapy to more advanced topical PDT, lasers and a combination of both. We found that effectiveness does not depend on the technique itself but instead on the number of lesions, financial cost, psychological factors, skin phototype and age. Our work shows that SGH can be treated effectively by customizing the treatment modality according to different parameters, while effectively maintaining clearance of SGH lesions with best cosmetic outcome.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Multidisciplinary Sciences
Qihong Yu, Jin-Xin Liu, Xichuan Zheng, Xueke Yan, Peng Zhao, Chuanzheng Yin, Wei Li, Zifang Song
Summary: This study reveals the significant role of Sox9 in mediating autophagy-dependent vSMC phenotypic modulation and the development of TA. Inhibition of Sox9 expression can attenuate neointimal formation, providing a potential therapeutic approach for vascular pathologies.
Article
Dermatology
Shiho Tanaka, Hiroaki Sakaue, Toshikazu Koiwai, Natsuki Okuda, Katsuki Okuyama, Yoshihiko Horioka, Yasunari Hiramatsu, Makoto Kawashima, Naoko Ishiguro, Takashi Sato
Summary: In this study, it was found that near-infrared radiation causes sebaceous gland enlargement and skin thickening in hamsters. The mechanism involves the proliferation of sebocytes and the increase in reactive oxygen species levels, leading to the transcriptional augmentation of epidermal growth factor receptor production. These findings provide new evidence for the understanding of the effects of near-infrared radiation on the skin.
EXPERIMENTAL DERMATOLOGY
(2023)
