Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site
出版年份 2016 全文链接
标题
Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site
作者
关键词
-
出版物
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 31, Issue sup4, Pages 170-175
出版商
Informa UK Limited
发表日期
2016-07-20
DOI
10.1080/14756366.2016.1201812
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting mitochondria metabolism for cancer therapy
- (2015) Samuel E Weinberg et al. Nature Chemical Biology
- VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells
- (2015) Jonathan D. Moore et al. Oncotarget
- The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation
- (2014) Mulchand S. Patel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of ligand efficiency metrics in drug discovery
- (2014) Andrew L. Hopkins et al. NATURE REVIEWS DRUG DISCOVERY
- Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
- (2013) Shih-Chia Tso et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- How cancer metabolism is tuned for proliferation and vulnerable to disruption
- (2012) Almut Schulze et al. NATURE
- Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
- (2011) Mutsuko Kukimoto-Niino et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Microbial degradation of furanic compounds: biochemistry, genetics, and impact
- (2011) Nick Wierckx et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Semiempirical Quantum Mechanical Method PM6-DH2X Describes the Geometry and Energetics of CK2-Inhibitor Complexes Involving Halogen Bonds Well, While the Empirical Potential Fails
- (2011) Petr Dobeš et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC
- (2010) Luke H. Stockwin et al. INTERNATIONAL JOURNAL OF CANCER
- Third-Generation Hydrogen-Bonding Corrections for Semiempirical QM Methods and Force Fields
- (2010) Martin Korth Journal of Chemical Theory and Computation
- Severe encephalopathy and polyneuropathy induced by dichloroacetate
- (2010) Dieta Brandsma et al. JOURNAL OF NEUROLOGY
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Pivotal Role of the C-terminal DW-motif in Mediating Inhibition of Pyruvate Dehydrogenase Kinase 2 by Dichloroacetate
- (2009) Jun Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Consistent van der Waals Radii for the Whole Main Group
- (2009) Manjeera Mantina et al. JOURNAL OF PHYSICAL CHEMISTRY A
- Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition
- (2008) Mark E. Schnute et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started