Article
Materials Science, Multidisciplinary
Linda Waldherr, Maria Seitanidou, Marie Jakesova, Verena Handl, Sophie Honeder, Marta Nowakowska, Tamara Tomin, Meysam Karami Rad, Tony Schmidt, Joachim Distl, Ruth Birner-Gruenberger, Gord Campe, Ute Schafer, Magnus Berggren, Beate Rinner, Martin Asslaber, Nassim Ghaffari-Tabrizi-Wizsy, Silke Patz, Daniel T. Simon, Rainer Schindl
Summary: The study confirms Gem's significantly greater potency in killing GBM cells compared to temozolomide, and demonstrates the potential of the electronically-driven organic ion pump GemIP for targeted delivery to GBM cells.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Oncology
Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li, Md Abdus Subhan, Farzana Parveen, Janaina Artem Ataide, Bharat Ashok Rajmalani, Vladimir P. Torchilin
Summary: Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to traditional cancer treatments. The unique biology of GBM cells and the blood-brain barrier contribute to this resistance. However, there are several treatment options available, including surgery, chemoradiotherapy, adjuvant chemotherapy, immunotherapy, targeted therapies, and tumor-treating fields. Ongoing clinical trials aim to improve outcomes for GBM patients.
Article
Materials Science, Biomaterials
Chang Du, Chenwei Wang, Shu-Heng Jiang, Xiangqin Zheng, Zelong Li, Yong Yao, Yue Ding, Tingting Chen, Huan Yi
Summary: In this research, a ferrocene-containing supramolecular nanomedicine (PFC/GOD-TPZ) with a PEG corona and disulfide-bond cross-linked core was designed to simultaneously encapsulate 4-di-N-oxide tirapazamine (TPZ) and glucose oxidase (GOD). The PEG corona of PFC/GOD-TPZ could detach responsively at weakly acidic tumor pH, enhancing cellular internalization. Glutathione (GSH) triggered the drug release by cleavaging the disulfide-bond cross-linked core, leading to cascade reactions generating H2O2 and activating the cytotoxic therapeutic agent benzotriazinyl (BTZ) radical.
BIOMATERIALS SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Maya A. Dymova, Elena Kuligina, Vladimir A. Richter
Summary: This review summarizes recent advances in understanding the molecular mechanisms of therapeutic resistance of GBM, molecular characteristics of glioblastoma cells, and barriers in the brain that contribute to drug resistance. The progress in developing new targeted drugs for glioblastoma and drug delivery across the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Chemical
Tamer M. Shehata, Heba S. Elsewedy
Summary: This study successfully formulated PEGylated PX nanoemulsion with appropriate particle size for intravenous administration, moderate in vitro release, and low hemolytic activity, demonstrating its promising anti-proliferative effect.
Article
Immunology
Bahareh Vakili, Mahboubeh Karami-Darehnaranji, Esmaeil Mirzaei, Farnaz Hosseini, Navid Nezafat
Summary: Graphene, as a new type of vaccine adjuvant, has been found to enhance antigen immunogenicity and stimulate immune responses. However, its injection may lead to oxidative stress and inflammation, thereby requiring modifications to reduce adverse effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gioacchino Schifino, Claudio Gasparini, Simone Drudi, Marta Giannelli, Giovanna Sotgiu, Tamara Posati, Roberto Zamboni, Emanuele Treossi, Emanuele Maccaferri, Loris Giorgini, Raffaello Mazzarro, Vittorio Morandi, Vincenzo Palermo, Monica Bertoldo, Annalisa Aluigi
Summary: In this study, keratin/poly(lactic acid) blend nanofibers with different loadings of graphene-oxide were prepared and tested as drug delivery systems. The addition of graphene-oxide improved the performance of the nanofibers and slowed down the drug release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Federica Catania, Elena Marras, Mauro Giorcelli, Pravin Jagdale, Luca Lavagna, Alberto Tagliaferro, Mattia Bartoli
Summary: Graphene, with its remarkable properties, has brought about a significant change in the field of material science. Recent achievements in the biological applications of graphene and related materials show great potential for future advancements.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Weiqian Ma, Huailin Yang, Yanfang Hu, Li Chen
Summary: A reduced-graphene-oxide-based drug delivery system was developed for combination therapy, utilizing PEGylated THPPEG to modify rGO and achieve good biocompatibility and water solubility. The system integrated photothermal therapy with photodynamic therapy, showing significant potential for future cancer treatment.
POLYMER INTERNATIONAL
(2021)
Review
Oncology
Tapan Behl, Aditi Sharma, Lalit Sharma, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Mirela Marioara Toma, Daniela Gitea, Elena Emilia Babes, Claudia Teodora Judea Pusta, Adrian Gheorghe Bumbu
Summary: GBM is a highly aggressive tumor with poor prognosis and limited treatment options, leading to the need for the development of more effective therapeutic strategies. Natural compounds are suggested as possible solutions to combat GBM, offering potential benefits in reducing oxidative stress and inflammation, inhibiting proliferation, inducing apoptosis, and enhancing anti-tumor therapies. Targeting cellular pathways and utilizing advanced drug delivery techniques may provide novel approaches for the treatment of GBM.
Article
Biochemistry & Molecular Biology
Bilal Javed, Xinyi Zhao, Daxiang Cui, James Curtin, Furong Tian
Summary: The study synthesized Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel loaded with curcumin and piperine to treat GBM, which exhibited enhanced anticancer properties, improved drug toxicity and release, and induced apoptosis through endocytic pathways. The experimental evidence suggests that the combinatorial curcumin-piperine gold nanogels have the potential to overcome the limitations of conventional chemotherapeutic treatments for glioma cells.
Review
Pharmacology & Pharmacy
Zufika Qamar, Ali Sartaj, Mohammad Kashif Iqubal, Farheen Fatima Qizilbash, Suhaira Sabir, Javed Ali, Asgar Ali, Sanjula Baboota
Summary: This article provides a brief review of using various lipid-based nanocarriers loaded with drug combinations against GBM.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Asif Mohd Itoo, Sree Lakshmi Vemula, Mahima Tejasvni Gupta, Mahesh Vilasrao Giram, Sangishetty Akhil Kumar, Balaram Ghosh, Swati Biswas
Summary: This review discusses the potential applications of two-dimensional graphene oxide nanoparticles in cancer therapy, including drug delivery, chemo-photothermal therapy, bioimaging, etc. It also examines the challenges and opportunities associated with these applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Giuseppe Di Mauro, Roberta Amoriello, Neus Lozano, Alberto Carnasciali, Daniele Guasti, Maurizio Becucci, Giada Cellot, Kostas Kostarelos, Clara Ballerini, Laura Ballerini
Summary: In neuroinflammation, astrocytes respond to pro-inflammatory cytokines (CKs) through Ca2+ signaling and play important roles in disease progression. Graphene oxide (GO) nanoparticles offer a promising approach to target astrocytes and regulate their reactivity. This study investigates the effects of CKs on astrocytic Ca2+ signaling and demonstrates the potential of GO to reverse the dysregulated cellular changes in astrocytes. The findings suggest that GO-based therapeutics may be effective in treating immune-mediated neuroinflammatory diseases.
Article
Polymer Science
Erhan Demirel, Yasemin Yuksel Durmaz
Summary: Combination therapy involving anticancer drugs and gene therapy agents has been proven effective in treating different types of cancer. In this study, a modified strategy was developed to enhance the use of reduced graphene oxide (rGO) as a carrier for delivering drugs and nucleotides. The newly designed copolymer allowed for the conjugation of a targeting peptide and the loading of hydrophobic drugs, resulting in a multifunctional nanoplatform with controlled drug release and high transfection efficiency. The experiments demonstrated the potential of this nanoplatform in selectively delivering different cargoes to tumor sites.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Cell Biology
Anirudh Pillai, Akhila Gungi, Puli Chandramouli Reddy, Sanjeev Galande
Summary: Studying cnidarians like Hydra can enhance our understanding of the evolutionary foundations underlying eumetazoan tissue development, homeostasis, and regeneration. These organisms exhibit unique regenerative potential and continuously active axial patterning, necessitating large-scale gene expression changes governed by a variety of epigenetic mechanisms within cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Saurabh J. Pradhan, Puli Chandramouli Reddy, Michael Smutny, Ankita Sharma, Keisuke Sako, Meghana S. Oak, Rini Shah, Mrinmoy Pal, Ojas Deshpande, Greg Dsilva, Yin Tang, Rakesh Mishra, Girish Deshpande, Antonio J. Giraldez, Mahendra Sonawane, Carl-Philipp Heisenberg, Sanjeev Galande
Summary: Activation of the zygotic genome is a critical transition during development, though the link to tissue-specific gene regulation remains unclear. Here the authors demonstrate distinct functions for Satb2 before and after zygotic genome activation, highlighting the temporal coordination of these roles.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Nutan Rani, Nidhi Goswami, Sapna Yadav, Dipak Maity, Sachin Patil, Kalawati Saini
Summary: In this study, a method for the efficient and eco-friendly biosynthesis of hydrophilic zinc oxide nanoparticles (ZnO NPs) for antidiabetic treatment was reported. The as-synthesized nanoparticles showed good dispersibility and stability, and exhibited significant antidiabetic potential in in vitro and in vivo experiments.
Article
Materials Science, Multidisciplinary
Sachin Patil, Vishnu S. Mishra, Puli Chandramouli Reddy, Bimlesh Lochab
Summary: Researchers have developed a nanoformulation using nanodiamonds and iron oxide, which effectively delivers artesunate (ART) to cancer cells, increasing its anticancer properties. This nanoformulation enhances the production of reactive oxygen species (ROS), leading to DNA damage and cellular apoptosis.
ACS MATERIALS LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Sachin Patil, Vishnu S. Mishra, Nisha Yadav, Puli Chandramouli Reddy, Bimlesh Lochab
Summary: This study demonstrates the potential applications of nanodiamonds in drug delivery. The modified nanodiamonds showed enhanced stability and controlled release of the loaded drug. The nanodiamond-drug conjugates exhibited significant inhibitory effects on cancer cells and potential for treating glioblastoma multiforme.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Sachin Patil, Vishnu S. Mishra, Nisha Yadav, Puli Chandramouli Reddy, Bimlesh Lochab
Summary: In this study, a new nanocarrier was successfully prepared by modifying nanodiamonds. The nanocarrier exhibited stable dispersion in aqueous solution and could effectively encapsulate poorly water-soluble drugs. The results demonstrated that the nanocarrier had high cellular uptake in tumor cells and could control and sustain drug release, leading to reduced cell viability and suppressed tumor proliferation.
ACS APPLIED BIO MATERIALS
(2022)