Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy

MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment

(2021) Ying Lu et al.   GASTROENTEROLOGY

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Ubiquitin-Specific Protease 21 Promotes Colorectal Cancer Metastasis by Acting as a Fra-1 Deubiquitinase

(2020) Sun-Il Yun et al.   Cancers

CRISPR screen in regulatory T cells reveals modulators of Foxp3

(2020) Jessica T. Cortez et al.   NATURE

The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation

(2020) Jing Yang et al.   EMBO REPORTS

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

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PD-1/PD-L1 pathway: Basic biology and role in cancer immunotherapy

(2019) Arash Salmaninejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

(2019) Pingping Hou et al.   GENES & DEVELOPMENT

VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancers

(2019) Chang Gon Kim et al.   Science Immunology

Regulation and Function of the PD-L1 Checkpoint

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Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity

(2018) Elise Alspach et al.   Cold Spring Harbor Perspectives in Biology

The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth

(2018) Wenjuan Li et al.   Cell Death & Disease

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

(2018) Ziliang Dong et al.   NANO LETTERS

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

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Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

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(2016) David H Munn et al.   CURRENT OPINION IN IMMUNOLOGY

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

(2016) Jiali Jin et al.   Nature Communications

USP21 prevents the generation of T-helper-1-like Treg cells

(2016) Yangyang Li et al.   Nature Communications

A Translational Perspective of a Deubiquitinase Inhibitor in Antitumor Immunity

(2016) Yangyang Li et al.   EBioMedicine

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

(2016) Liqing Wang et al.   EBioMedicine

Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms

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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

(2013) Zuojia Chen et al.   IMMUNITY

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

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(2012) Ethan Cerami et al.   Cancer Discovery

Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

(2009) Frank A. Sinicrope et al.   GASTROENTEROLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

A superoxide anion generator, pyrogallol, inhibits the growth of HeLa cells via cell cycle arrest and apoptosis

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