期刊
SCIENCE ADVANCES
卷 8, 期 30, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abn5360
关键词
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资金
- National Key R&D Program of China [2019YFA0110500]
- International Science and Technology Cooperation Program of Guangdong Province [2019A050510028]
- Guangdong Pearl River Talents Program [2017GC010411]
- National Natural Science Foundation of China [31961133017, 31961133018, 31961133019, 82020108020, 81873941, 21761132013, 31870859]
- Ministry of Science and Technology of China [2018YFA0900200]
- Tsinghua University-INDITEX Sustainable Development Fund [TISD201907]
- Center of Life Sciences of Tsinghua-Peking University
- European Union [870294]
Organohydrogels with stability and good biocompatibility were successfully fabricated using click chemistry and the combination of two-dimensional materials. These hydrogels demonstrated fatigue resistance, long-term stability in body fluids, and exhibited excellent performance in in vitro and in vivo experiments.
Hydrogels are used in vascular tissue engineering because of their good biocompatibility. However, most natural hydrogels exhibit high swelling ratio, poor mechanical stability, and low durability, which are key limitations for wider applications. Amphiphilic and fatigue-resistant organohydrogels were fabricated here via the click chemical reaction of unsaturated functional microbial polyhydroxyalkanoates and polyethylene glycol diacrylate and a combination of two-dimensional material graphdiyne. These organohydrogels were maintained stable in body fluids over time, and their tensile moduli remained unchanged after more than 2000 cycles of cyclic stretching. The tubular scaffolds presented good biocompatibility and perfusion in vitro. After transplantation in vivo, the vascular grafts exhibited obvious cell infiltration and tissue regeneration, having a higher patency rate than the control group in 3 months. This fabrication method provides a strategy of improving and promoting the application of organohydrogels as implant materials for small-diameter vascular graft.
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