Article
Energy & Fuels
L. Shiamala, K. Vignesh, B. M. Jaffar Ali
Summary: This study explores photocatalysis as an alternative method for upstream processing in bioethanol production. By using a highly efficient visible light active TiO2-Bi2WO6 photocatalyst to deconstruct potato mash and casuarina sawdust, and subjecting the deconstructed biomass to fermentation by yeast, it was found that the ethanol yield from photocatalytically deconstructed biomass is comparable to that of biomass processed by standard enzymatic hydrolysis.
Article
Chemistry, Multidisciplinary
Yite Li, Liqian Liu, Tian Meng, Lei Wang, Zhigang Xie
Summary: An ionic ZIF-8@iCOF nanocomposite was designed as a sunlight-driven photocatalytic filter, which achieved improved visible light absorption and enhanced ROS generation, resulting in antibacterial efficiency of 99.99999%. Furthermore, the combination of the material with a commercial polymer formed fibrous membranes with high interception efficiency, good biocompatibility, and strong bacteria elimination under sunlight conditions.
Article
Chemistry, Physical
C. Mrabet, R. Jaballah, N. Mahdhi, A. Boukhachem, M. Amlouk
Summary: The formation of heterojunctions is commonly used to enhance photocatalytic efficiency. In this study, the photocatalytic activity of CuO-ZnO nanocomposite thin films was investigated and found to be greater than that of individual semiconductors. The produced nanocomposite thin films might be beneficial for environmentally friendly and energy-saving wastewater treatment.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Nanoscience & Nanotechnology
Xiaofeng Zhou, Fei Yan, Bo Shen, Jiwei Zhai, Niklas Hedin
Summary: Research has shown that utilizing the force-induced electric polarization field of piezoelectric semiconductors can enhance the transfer rate of photoexcited charge carriers, but effectively improving the photocatalytic reactivity and solar-to-chemical conversion efficiency of piezoelectric materials remains a challenge. By preparing catalysts based on nanopiezoelectric heterostructures, higher amounts of radicals and H2O2 concentrations were achieved, leading to increased piezophotocatalytic activities with improved separation and transportation of photoexcited charge carriers.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Shuailong Yang, Rongjian Sa, Hong Zhong, Haowei Lv, Daqiang Yuan, Ruihu Wang
Summary: In this study, a nickel-modified COF was reported to enhance the photocatalytic reduction of CO2 by modifying the linkage microenvironment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Deepalekshmi Ponnamma, Yara Elgawady, Sabari S. Nair, Mohammad K. Hassan, Mariam Al Ali Al-Maadeed
Summary: Highly stable and efficient coaxial electrospun fibers of PVA and PLA nanocomposites filled with TiO2 nanotubes were successfully prepared for natural sunlight-driven photocatalytic dye degradation, achieving approximately 80-85% degradation. The coaxial electrospinning process influenced the structure and performance of the nanofibers, optimizing the distribution of TiO2. The photocatalytic activity and distribution of TiO2 played a key role in the efficiency of dye degradation.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Polymer Science
Ume Arfa, Mubark Alshareef, Nimra Nadeem, Amjed Javid, Yasir Nawab, Khaled F. Alshammari, Usman Zubair
Summary: To reduce the harm to the ecosystem caused by frequent washing of textiles, this study proposes the development of sunlight-driven cleaning and antibacterial comfort fabrics by immobilizing functionalized Zn-doped TiO2 nanoparticles. A sol-gel method was used to fabricate the nanoparticles, which were then functionalized and immobilized on cotton fabric using silane coupling agents. The as-functionalized fabrics showed a high potential for sunlight-assisted degradation of selected pollutants, with 95-98% dye degradation achieved within 3 hours of sunlight exposure. The treated fabrics also maintained their comfort and mechanical properties. The reaction pathway followed a first-order kinetic model, with h(+) ions identified as the most influential species for dye degradation.
Article
Chemistry, Multidisciplinary
Pablo Salcedo-Abraira, Artem A. Babaryk, Eva Montero-Lanzuela, Oscar R. Contreras-Almengor, Maria Cabrero-Antonino, Erik Svensson Grape, Tom Willhammar, Sergio Navalon, Erik Elkaim, Hermenegildo Garcia, Patricia Horcajada
Summary: IEF-11 is a new porous titanium(IV) squarate metal-organic framework with permanent porosity and excellent chemical stability. Combining photoactive Ti(IV) and electroactive squarate, IEF-11 exhibits relevant optoelectronic properties used in photocatalytic overall water splitting reaction, producing record H-2 amounts for MOF-based materials under simulated sunlight without any activity loss for at least 10 days.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Archana Venkatachalam, John Abel Martin Mark, D. Deivatamil, J. Revathi, Joseph prince Jesuraj
Summary: Fe2O3@MgO, Fe2O3@Mn2O3, and Fe2O3@Co3O4 nanocomposites were synthesized using a two-pot wet chemical procedure. The study included analysis of structure, optical properties, surface morphology, elemental composition, porosity, surface area, functional groups, and photocatalytic activity. Experimental results were obtained through techniques like PXRD, PL, DRS, SEM, EDAX, BET, FTIR, and tests using MB, RhB, Phenol, COD, and radical scavengers.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Environmental Sciences
M. Beaula Ruby Kamalam, S. S. R. Inbanathan, K. Sethuraman, Ahmad Umar, Hassan Algadi, Ahmed A. Ibrahim, Qazi Inamur Rahman, Christos S. Garoufalis, Sotirios Baskoutas
Summary: In this study, a V2O5 nanorods/GO nanocomposite was synthesized and used as an efficient photocatalyst for the degradation of VB dye under direct sunlight illumination, achieving almost complete degradation within 90 minutes. The excellent photocatalytic efficiency was attributed to the outstanding transfer of interfacial charge and the suppression of charge-carrier recombination. Kinetics of the degradation process was analyzed by calculating rate constants and half-life times, and a possible mechanism for the degradation process was discussed.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xiaoqian Ai, Shun Yan, Chao Lin, Kehong Lu, Yujie Chen, Ligang Ma
Summary: CeO2@ZnO nanocomposites were prepared by pyrolyzing Ce@Zn metal-organic frameworks, which showed improved photocatalytic performance due to the formation of a nanoheterojunction structure. The effects of the Zn:Ce ratio on the microstructure, morphology, and optical properties of the nanocomposites were studied. The prepared photocatalysts exhibited higher photocatalytic activity than previously reported CeO2@ZnO nanocomposites, suggesting their potential in environmental remediation.
Article
Materials Science, Ceramics
Warda Shahzad, Ahmad K. Badawi, Zulfiqar A. Rehan, Asad Muhammad Khan, Rafaqat Ali Khan, Faheem Shah, Shahid Ali, Bushra Ismail
Summary: In search of better materials for visible light photocatalytic performance, perovskite Sr-0.3(Ba/Mn)(0.7)ZrO3 nanopowders anchored on graphene oxide were synthesized. The photocatalytic activity against methylene blue was evaluated. Chemical coprecipitation method and annealing at high temperature were used to synthesize the composite, resulting in improved charge separation and generation of hydroxyl radicals.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Hira Ashiq, Nimra Nadeem, Asim Mansha, Javed Iqbal, Muhammad Yaseen, Muhammad Zahid, Imran Shahid
Summary: The study presents a novel sunlight active heterogeneous photocatalyst for efficient degradation of rhodamine B dye. The composite catalyst was well characterized and showed outstanding photocatalytic activity and charge separation effects.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2022)
Article
Engineering, Environmental
Mekdes Gerawork
Summary: Heterogeneous photocatalysis using nanocomposites, particularly those impregnated with eggshells, has shown promising results in degrading organic dyes in industrial wastewater, indicating great potential for environmental applications.
WATER SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Naima Saif, Ayesha Tariq, Azeem Intisar, Zahida Batool, Muhammad Arshad, Aziz Ur Rehman, Rehana Kousar
Summary: Green synthesis was used to successfully synthesize SnO2 and SnO2/MoO3 composite. The leaf extract of Magnifera indica was employed as a reducing agent to produce nanomaterials with rod shape morphology. The synthesized nanomaterials were characterized by FTIR, XRD, and SEM, and exhibited enhanced photocatalytic performance in the degradation of Methylene blue compared to pure SnO2. The bandgap energy of SnO2/MoO3 composite was found to be 3.36 eV, lower than that of SnO2 (3.60 eV), leading to improved photocatalytic efficiency.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Pharmacology & Pharmacy
Mohamed Y. Y. Zakaria, Shady M. M. Abd El-Halim, Botros Y. Y. Beshay, Islam Zaki, Mohammed A. S. Abourehab
Summary: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a global catastrophe, prompting the development of a safe and effective therapeutic system. Polyphenols such as resveratrol (RSV) have proven antiviral activity. However, RSV suffers from limited solubility and degradation in the gastrointestinal tract and liver, hindering its clinical use. PEGylated bilosomes (PBs) containing a PEGylated edge activator were proposed to enhance the permeability and bioavailability of RSV. The optimized formula (F5) showed improved dissolution behavior, increased cellular uptake, and complete in vitro suppression of SARS-CoV-2, suggesting it as a promising oral treatment for SARS-CoV-2 infection.
Article
Chemistry, Analytical
Ahmed A. Hamad, Yasser F. Hassan, Walid E. Eltoukhi, Sayed M. Derayea, Mohammed A. S. Abourehab, Bassam S. Mohammed
Summary: A green, fast, and easy fluorimetric technique for the assay of mitoxantrone (MXN) as a topoisomerase type II enzyme suppressor was developed. Methanol was shown to enhance the intrinsic fluorescence of MXN. The method achieved linearity in the range of 0.02-1.50 μg ml(-1) and had low toxicity.
Article
Biochemistry & Molecular Biology
Mohammed M. Amin, Gamal El-Din A. Abuo-Rahma, Montaser Sh. A. Shaykoon, Adel A. Marzouk, Mohammed A. S. Abourehab, Roshdy E. Saraya, Mohamed Badr, Ahmed M. Sayed, Eman A. M. Beshr
Summary: This study successfully synthesized thirteen novel 8-hydroxyquinoline/chalcone hybrids, compounds 3a-m, which showed promising anticancer activity. Among these compounds, 3e and 3f exhibited superior activity against cancer cells and better safety towards normal cells compared to Staurosporine. Furthermore, compounds 3e, 3d, and 3i demonstrated good inhibition of tubulin polymerization and compounds 3e, 3l, and 3f showed EGFR inhibition. These compounds also showed potential effects on cell cycle, apoptosis induction, and gene suppression. In-silico molecular docking and other studies validated their dual mechanisms and bioavailability standards.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shoaib Khan, Shahid Iqbal, Muhammad Taha, Rafaqat Hussain, Fazal Rahim, Mazloom Shah, Nasser S. Awwad, Hala A. Ibrahium, Mohammed Issa Alahmdi, Ayed A. Dera, Hayat Ullah, Ali Bahadur, Samar O. Aljazzar, Eslam B. Elkaeed, Muhammad Rauf
Summary: The clinical significance of benzimidazole-containing drugs has increased, and research interest in these moieties is strong due to their diverse biological features. This study aimed to synthesize a new series of benzimidazole analogs and evaluate their inhibitory activity against alpha-amylase and alpha-glucosidase. Most of the derivatives showed promising activity, with analog 2 displaying the best inhibitory activity. The structure-activity relationship (SAR) was determined by examining the substitution effects, and molecular docking provided insights into the interactions between the active substances and the targeted enzymes.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Moataz A. Shaldam, Denisa Hendrychov, Radwan El-Haggar, Veronika Voj, Taghreed A. Majrashi, Eslam B. Elkaeed, Nicolas Masurier, Vladimir Krystof, Haytham O. Tawfik, Wagdy M. Eldehna
Summary: A study reports the development of novel derivatives of pyrimido[1,2-a]benzimidazole as potential anti-AML agents. Compound 5h exhibited effective anti-tumor activity at low micromolar concentration, particularly against leukemia. Furthermore, compounds 5e-h showed single-digit micromolar activity against acute leukemia cell lines. Pyrimido[1,2-a]benzimidazoles 5e and 5h significantly inhibited BMX kinase.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Ibrahim H. Eissa
Summary: This study aimed to discover new thieno[2,3-d]pyrimidine derivatives as EGFR tyrosine kinase inhibitors. Nine derivatives were designed, synthesized, and evaluated in vitro and in silico. Compound 7a showed significant inhibitory effects against both EGFR wild-type and EGFR(T790M), inducing apoptosis and arresting cell growth. Docking and molecular dynamics simulation confirmed the stable binding modes of the synthesized compounds. Compound 7a is a promising dual EGFR inhibitor for cancer treatment.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Misbah Umar, Humayun Ajaz, Mohsin Javed, Shahid Iqbal, Muhammad Shuaib Khan, Ahmad Alhujaily, Nasser S. Awwad, Hala A. Ibrahium
Summary: This study successfully synthesized manganese oxide nanoparticles and analyzed their properties through various testing methods. Under light conditions, the nanoparticles showed good performance in degrading pollutants and inhibiting bacteria. Different bacterial strains showed varying levels of sensitivity to manganese oxide nanoparticles.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Asma Khan, Hongli Wen, Shahid Iqbal, Mujaddad-ur Rehman, Mazloom Shah, Muhammad Raheel, Farhan Ahmad Khan, Rashid Khan, Randa A. Althobiti, Eman Alzahrani, Abd-ElAziem Farouk, Foziah F. Al-Fawzan, Eslam B. Elkaeed
Summary: Organic-inorganic hybrid perovskite materials have limitations due to stability and toxicity issues, but the lead-free hybrid bismuth-based compound TBI shows excellent light-absorbing properties and phase stability, making it a potential absorber for photovoltaic and solar cell applications.
Article
Pathology
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Dalal Z. Husein, Mostafa A. Asmaey, Ibrahim M. Ibrahim, Ahmed M. Metwaly
Summary: T-1-MCPAB is a promising VEGFR-2 inhibitor with potential for breast cancer treatment, showing good drug-likeness and anti-cancer effects in vitro.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Sadaf Sarfraz, Muhammad Saeed, Mohsin Javed, Nadia Hussain, Shahid Iqbal, Shahid Amin, Ali Bahadur, Ahmed Hussain Jawhari, Randa A. Althobiti, Eman Alzahrani, Abd-ElAziem Farouk, Samar O. Aljazzar, Eslam B. Elkaeed
Summary: In this paper, a selective, precise, and cost-effective analytical method for measuring the active pharmaceutical ingredient of daclatasvir dihydrochloride using RP-HPLC technique was reported. The method has been verified using industry-recognized criteria and can be used for qualitative and quantitative analysis in pharmaceutical labs.
JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ahmed M. Metwaly, Ahmed M. Abdel-Raoof, Abdulaziz M. Alattar, Adham A. El-Zomrawy, Ashraf M. Ashmawy, Metwally G. Metwally, Mohamed A. Abu-Saied, Asmaa M. Lotfy, Bshra A. Alsfouk, Eslam B. Elkaeed, Ibrahim H. Eissa
Summary: The study focuses on the preparation of patuletin-encapsulated chitosan nanoparticles (PT-CS-NPs) using the ionic gelation method. The synthesized PT-CS-NPs showed promising anticancer activity and safety profiles. Additionally, a reliable method for the quantification of patuletin (PT) was established through electrochemical analysis.
JOURNAL OF CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Mohammad Sameer Khan, Afsana Sheikh, Mohammed A. S. Abourehab, Neelima Gupta, Prashant Kesharwani
Summary: Cancer remains a challenging disease without a complete cure. Researchers are exploring new treatment approaches, but the dynamic genetic changes of cancer cells and their resistance to treatment make these innovations often temporary. Overcoming resistance and improving survival continue to be ongoing needs.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Tanzeela Fazal, Shahid Iqbal, Mujaddad-ur Rehman, Azam Hayat, Mazloom Shah, Sajid Mahmood, Khurram Shoaib, Ahmad Alhujaily, Bibi Nazia Murtaza, Sedra tul Muntaha, Randa A. Althobiti, Eman Alzahrani, Abd-ElAziem Farouk, Foziah F. Al-Fawzan, Eslam B. Elkaeed
Summary: Biological production of nanomaterials is an environmentally friendly and stable approach. In this study, silver iron oxide nanoparticles were synthesized using Escherichia coli bacterium, showing antimicrobial and photocatalytic degradation properties, as well as hydrogen generation potential.
MATERIALS CHEMISTRY AND PHYSICS
(2024)
Article
Pathology
Ibrahim H. Eissa, Reda G. Yousef, Muhammad Sami, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein, Hazem Elkady, Ahmed M. Metwaly
Summary: This study developed and evaluated BHEPN as a potential inhibitor of VEGFR-2. The results showed that BHEPN inhibited VEGFR-2 and exhibited significant cytotoxic effects against cancer cell lines. Moreover, BHEPN was able to induce apoptosis and inhibit cell migration in HepG2 cells.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Hesham Haffez, Nosaiba A. Elsayed, Marwa F. Ahmed, Samar S. Fatahala, Eman F. Khaleel, Rehab Mustafa Badi, Eslam B. Elkaeed, Mahmoud A. El Hassab, Sherif F. Hammad, Wagdy M. Eldehna, Nicolas Masurier, Radwan El-Haggar
Summary: Significant advancements have been made in the design and synthesis of novel compounds as potential anticancer and VEGFR-2 inhibitors. Two compounds showed strong inhibitory activity and induced apoptosis and cell cycle arrest in vitro.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)