期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.937871
关键词
Hashimoto's thyroiditis; cancer risk; observational study; systematic review; meta-analysis
资金
- Construction project for National Regional Chinese medicine surgery diagnosis and treatment center(2018)
- Construction project for Shanghai Municipal Health Commission East China Area of TCM special disease alliance(2021)
- Construction project for Shanghai Municipal Health Commission key clinical speciality [shslczdzk03801]
- Construction project for Shanghai Municipal Health Commission inheritance and innovation team of the Shanghai-style Traditional Chinese Medicine [2021LPTD-001]
The research indicates that patients with Hashimoto's thyroiditis may have an increased risk of developing various types of cancer, including breast cancer, urogenital cancer, digestive organs cancer, etc., while there is also a decreased risk of other types of cancer.
Objective: Research data suggest that patients with Hashimoto's thyroiditis may increase the risk of cancer. However, existing research is inconsistent with this view. Therefore, to investigate the effect of Hashimoto's thyroiditis on the risk of developing cancer, we conducted this study. Methods: We searched the PubMed and Embase databases from database establishment until March 2022. After rigorous literature screening by two authors, 23 studies that met the inclusion criteria were identified, and the required data were independently extracted. Results: We retrieved 3591 records, and after the screening, 11 case-control studies and 12 cohort studies were included in the analysis. Data analysis suggested that patients with Hashimoto's thyroiditis had an increased risk of developing breast cancer, urogenital cancer, digestive organs cancer, hematologic cancer, and a low risk of respiratory cancers. Conclusions: This systematic review and meta-analysis showed that patients with HT may have a significantly increased risk of thyroid cancer, breast cancers, lung cancer, digestive system cancer, urogenital cancers, blood cancers, and prolactinoma people without HT.
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