4.3 Article

Application of fluoride disturbs plaque microecology and promotes remineralization of enamel initial caries

期刊

JOURNAL OF ORAL MICROBIOLOGY
卷 14, 期 1, 页码 -

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/20002297.2022.2105022

关键词

Fluoride; oral microecology; ICDAS II; 16S rRNA sequencing; enamel initial caries

资金

  1. Project of State Key Laboratory of Military Stomatology of China [2021YF001]
  2. Innovative Talents Promotion ProgramYouth Science and Technology Star Project [2019KJXX086]
  3. Shaanxi Key Research and Development Program [2021SF-032]
  4. Natural Science Basic Research Program of Shaanxi Province [2021JQ-353]

向作者/读者索取更多资源

This study found that fluoride application can significantly inhibit oral plaque microecology, alter microbial community structure, and have a positive effect on the demineralization and remineralization process of enamel initial caries.
Background The caries-preventive effect of topical fluoride application has been corroborated by a number of clinical studies. However, the effect of fluoride on oral microecology remains unclear. Objective To monitor the effect of fluoride on dental plaque microecology and demineralization/remineralization balance of enamel initial caries. Methods Three-year-old children were enrolled and treated with fluoride at baseline and 6 months. International Caries Detection and Assessment System II indices of 52 subjects were measured at baseline, 3, 6, and 12 months. Supragingival plaque samples of 12 subjects were collected at baseline, 3 and 14 days for 16S rRNA sequencing. Results Changes in microbial community structure were observed at 3 days after fluoridation. Significant changes in the relative abundance of microorganisms were observed after fluoride application, especially Capnocytophaga, unidentified Prevotellaceae and Rothia. Functional prediction revealed that cell movement, carbohydrate and energy metabolism were affected significantly after fluoride application. Fluoride significantly inhibited enamel demineralization and promoted remineralization of early demineralized caries enamel at 3 months. Conclusion Fluoride application significantly inhibited the progression of enamel initial caries and reversed the demineralization process, possibly by disturbing dental plaque microecology and modulating the physicochemical action of demineralization/remineralization. This deepened our understanding of caries-preventive effects and mechanisms of fluoride.

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