Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Review
Pharmacology & Pharmacy
Tao Sun, Chen Jiang
Summary: Drug delivery systems (DDS) triggered by local microenvironment represent the state-of-art of nanomedicine design, aiming to precisely recognize diseased sites, reduce side effects, and expand the therapeutic window. However, the design of DDS functioning at microcosmic levels is still challenging and underexploited.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Article
Chemistry, Multidisciplinary
Keli An, Xuqian Deng, Hongli Chi, Yuchao Zhang, Yan Li, Ming Cheng, Zhigang Ni, Zhi Yang, Chao Wang, Jinling Chen, Jianbo Bai, Chunyan Ran, Yong Wei, Juan Li, Penghui Zhang, Feng Xu, Weihong Tan
Summary: Proteolysis Targeting Chimeras (PROTACs) are a promising therapeutic modality for tackling undruggable and resistant issues in drug discovery. Researchers have developed a generalized caging strategy to synthesize stimuli-responsive PROTACs (sr-PROTACs) that can be activated and released in response to specific pathological cues and external triggers. These sr-PROTACs showed high solubility, long plasma exposure, and efficient protein degradation in tumor cells, making them potential candidates for personalized treatment and tissue engineering.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Yuzhe Sun, Edward Davis
Summary: The translation mentioned that achieving the promise of stimuli-responsive drug delivery systems for cancer treatment involves challenges like avoiding premature clearance, accumulating in tumors, and exhibiting appropriate payload release. However, the expanding toolbox of design tools from proof-of-concept studies each year helps address these requirements. Recent advances in targeting and stimuli-responsiveness, as well as challenges and potential solutions are discussed to assist researchers in overcoming interdisciplinary knowledge barriers and speeding up development in cancer therapy.
Article
Polymer Science
Katiuscia Vieira Jardim, Abraham F. Palomec-Garfias, Marcus Vinicius Araujo, Cesar Marquez-Beltran, Andris Figueiroa Bakuzis, Sergio Enrique Moya, Alexandre Luis Parize, Marcelo Henrique Sousa
Summary: Curcumin, a natural drug with promising potential in cancer therapy, has limited applicability due to its low solubility, short half-life, and low bioavailability. In this study, curcumin was encapsulated in stimuli-responsive magneto-polymeric nanoplatforms to improve its bioavailability and delivery efficiency. The results showed that magnetic hyperthermia can provide a means for the controlled release of curcumin, leading to enhanced therapeutic action.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Ranhua Xiong, Ronald X. Xu, Chaobo Huang, Stefaan De Smedt, Kevin Braeckmans
Summary: This review discusses the recent advances in stimuli-responsive nanobubbles for biomedical applications, highlighting their properties, synthesis methods, and potential advantages and limitations.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Review
Biotechnology & Applied Microbiology
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Nanocarriers (NCs) have attracted significant attention for their structural ability, good biocompatibility, and biodegradability. The development of NCs with stimuli-responsive properties has become a hot topic among scientists. These NCs can deliver drugs to tumors by regulating their pH, temperature, and enzyme responsiveness, thereby improving the accuracy of drug delivery and minimizing side effects. Material carriers for chemotherapeutic medicines are discussed in this review, with a focus on their structural properties and targeting methods that enhance therapeutic efficacy and trigger metabolic pathways. Overall, the development of NCs that respond to endogenous and exogenous stimuli in tumor regions and the understanding of their mechanisms have great potential for advancing tumor therapy and precision diagnosis in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ivanna Amarsy, Sebastien Papot, Gilles Gasser
Summary: Metal-based prodrugs are developed to overcome the drawbacks of metal-based compounds for biomedical applications, by utilizing tumor-associated stimuli for selective delivery. This field has significant applications in oncology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xingyue Ji, Zhiyuan Zhong
Summary: Gasotransmitters have unique pharmacological effects and potential therapeutic applications for various human diseases. However, their clinical translation is hindered by the lack of a reliable delivery form. The external stimuli-responsive prodrug strategy shows promise in delivering gasotransmitters with precise control. This review highlights the recent development of external stimuli-mediated decaging chemistry for the temporospatial delivery of gasotransmitters.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Ernest Szajna, Dalibor Matysek, Dariusz Bogdal
Summary: Epilepsy is a common neurological disease that can have a significant negative impact on quality of life, especially when symptoms are drug-resistant. Cannabidiol, derived from Cannabis Sativa, offers new hope for epilepsy treatment, with potential benefits in increasing bioactivity through transdermal delivery.
Article
Chemistry, Multidisciplinary
Ping-Ping He, Xiaoxue Du, Yuan Cheng, Qi Gao, Chang Liu, Xiaowen Wang, Yonghua Wei, Qilin Yu, Weiwei Guo
Summary: This study establishes a promising platform for highly efficient photothermal-chemo synergistic cancer therapy by integrating DNA hydrogels with MXene-based photothermal agent and doxorubicin as a loaded chemotherapeutic agent. The temperature rise caused by photothermal MXene nanosheets triggers the reversible gel-to-solution transition, releasing therapeutic agents for efficient localized cancer therapy.
Article
Pharmacology & Pharmacy
Xueqi Lin, Xingdi Wu, Xiang Chen, Ben Wang, Wen Xu
Summary: This review introduces stimuli-responsive drug delivery systems in eyes, summarizes their design and mechanisms, and briefly discusses their advantages and limitations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Multidisciplinary
Zhichang Du, Gangnan Zhao, Anyang Wang, Wei Sun, Shengli Mi
Summary: The paper introduces a microfluidic contact lens that integrates a microchannel and a micropump to achieve drug release through the mechanical action of blinking. Experimental results demonstrate the controllability of liquid release and the good flexibility, light transmittance, and biocompatibility of the microfluidic contact lens. The liquid exchange between the eye and the contact lens provides potential for personalized medicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Genetics & Heredity
Andrew S. Marriott, Nikki A. Copeland, Ryan Cunningham, Mark C. Wilkinson, Alexander G. McLennan, Nigel J. Jones
Article
Cell Biology
Nikki A. Copeland, Heather E. Sercombe, Rosemary H. C. Wilson, Dawn Coverley
JOURNAL OF CELL SCIENCE
(2015)
Article
Multidisciplinary Sciences
Patrice Rassam, Nikki A. Copeland, Oliver Birkholz, Csaba Toth, Matthieu Chavent, Anna L. Duncan, Stephen J. Cross, Nicholas G. Housden, Renata Kaminska, Urban Seger, Diana M. Quinn, Tamsin J. Garrod, Mark S. P. Sansom, Jacob Piehler, Christoph G. Baumann, Colin Kleanthous
Article
Cell Biology
Erin A. Greaves, Nikki A. Copeland, Dawn Coverley, Justin F. X. Ainscough
JOURNAL OF CELL SCIENCE
(2012)
Article
Multidisciplinary Sciences
Andrew S. Marriott, Olga Vasieva, Yongxiang Fang, Nikki A. Copeland, Alexander G. McLennan, Nigel J. Jones
Article
Pharmacology & Pharmacy
Hend Abdelrady, Rania M. Hathout, Rihab Osman, Imran Saleem, Nahed D. Mortada
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Urvi Thacker, Tekle Pauzaite, James Tollitt, Maria Twardowska, Charlotte Harrison, Adam Dowle, Dawn Coverley, Nikki A. Copeland
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Freya Ferguson, Alexander G. McLennan, Michael D. Urbaniak, Nigel J. Jones, Nikki A. Copeland
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Chemistry, Analytical
Ezgi Kivrak, Tekle Pauzaite, Nikki A. Copeland, John G. Hardy, Pinar Kara, Melike Firlak, Atike I. Yardimci, Selahattin Yilmaz, Fahreddin Palaz, Mehmet Ozsoz
Summary: A label-free electrochemical nanogenosensor was developed in this study for detecting point mutations in the genome generated by the CRISPR-Cas9 system, with high sensitivity and specificity. This method allows for rapid and easy investigation of gene editing products and has the potential to be further developed into an array system for multiplex detection of different gene editing outcomes.
Article
Biochemistry & Molecular Biology
Tekle Pauzaite, James Tollitt, Betul Sopaci, Louise Caprani, Olivia Iwanowytsch, Urvi Thacker, John G. Hardy, Sarah L. Allinson, Nikki A. Copeland
Summary: This study evaluates the inhibitory activity of two distinct DDK inhibitor chemotypes and finds that they have different effects on cellular proliferation, initiation of DNA replication, and replisome activity. PHA-767491 enhances its inhibitory effect by inhibiting both DDK and the CDK2-Rb-E2F transcriptional network.
Article
Polymer Science
Hanaa A. Galeb, Jonas Eichhorn, Sam Harley, Alexander J. Robson, Laurine Martocq, Steven J. Nicholson, Mark D. Ashton, Hend A. M. Abdelmohsen, Emel Pelit, Sara J. Baldock, Nathan R. Halcovitch, Benjamin J. Robinson, Felix H. Schacher, Victor Chechik, Koen Vercruysse, Adam M. Taylor, John G. Hardy
Summary: This study compares the properties of conjugated polymers derived from different phenolic monomers (catechol, levodopa, and homogentisic acid) using analytical chemistry techniques to understand their structure-function relationships. The polymers exhibit measurable conductivity and their electronic properties can be adjusted by functional groups on the polymer backbones, indicating their potential for electronic device applications.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Multidisciplinary Sciences
Manoj B. Sharma, Ozlem Kap, Hend A. M. Abdelmohsen, Mark D. Ashton, Garry R. Harper, Melike Firlak, Jasmine E. Aaltonen, Kerry A. Bolland, Ryan Bragg, Sarah Deeley, Ella Francis, Nahin Kazi, Bethany L. Mapley, Vasileios Oikonomou, Amal D. Aljohani, David Cheneler, Volkan Kilic, Nesrin Horzum, John G. Hardy
Summary: In vitro release of metformin, a drug used for cancer and diabetes treatment, from pHEMA hydrogel-based microneedle patches is demonstrated. The composition of pHEMA hydrogels can be adjusted to prepare robust microneedle patches with sufficient mechanical properties for skin penetration (insertion force of a single microneedle is approximately 40 N). Swelling experiments at different temperatures show temperature-dependent swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models. These pHEMA microneedles have potential for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
Review
Biochemistry & Molecular Biology
Tekle Pauzaite, Urvi Thacker, James Tollitt, Nikki A. Copeland
