Mineralocorticoid Receptor Signaling in the Inflammatory Skeletal Muscle Microenvironments of Muscular Dystrophy and Acute Injury

Current Practices in Treating Cardiomyopathy and Heart Failure in Duchenne Muscular Dystrophy (DMD): Understanding Care Practices in Order to Optimize DMD Heart Failure Through ACTION

(2022) Chet Villa et al.   PEDIATRIC CARDIOLOGY

Myeloid mineralocorticoid receptors contribute to skeletal muscle repair in muscular dystrophy and acute muscle injury

(2022) Zachary M. Howard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Early Inflammation in Muscular Dystrophy Differs Between Limb and Respiratory Muscles and Increases with Dystrophic Severity

(2021) Zachary M. Howard et al.   AMERICAN JOURNAL OF PATHOLOGY

Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

(2021) Christian Kupatt et al.   GENE THERAPY

Duchenne muscular dystrophy

(2021) Dongsheng Duan et al.   Nature Reviews Disease Primers

Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model

(2021) Zachary M. Howard et al.   JCI Insight

Therapeutic approaches to preserve the musculature in Duchenne Muscular Dystrophy: The importance of the secondary therapies

(2021) Giuseppe Angelini et al.   EXPERIMENTAL CELL RESEARCH

The DMD gene and therapeutic approaches to restore dystrophin

(2021) Fernanda Fortunato et al.   NEUROMUSCULAR DISORDERS

Mineralocorticoid receptor antagonism by finerenone is sufficient to improve function in preclinical muscular dystrophy

(2020) Jeovanna Lowe et al.   ESC Heart Failure

Development of Novel Micro-dystrophins with Enhanced Functionality

(2019) Julian N. Ramos et al.   MOLECULAR THERAPY

Mineralocorticoid receptor antagonists improve membrane integrity independent of muscle force in muscular dystrophy

(2019) J Spencer Hauck et al.   HUMAN MOLECULAR GENETICS

AAV-based gene therapies for the muscular dystrophies

(2019) Julie M Crudele et al.   HUMAN MOLECULAR GENETICS

Stabilization of Early Duchenne Cardiomyopathy With Aldosterone Inhibition: Results of the Multicenter AIDMD Trial

(2019) Subha V. Raman et al.   Journal of the American Heart Association

Mineralocorticoid Receptor Signaling Contributes to Normal Muscle Repair After Acute Injury

(2019) J. Spencer Hauck et al.   Frontiers in Physiology

The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling

(2018) Jonatan Barrera-Chimal et al.   KIDNEY INTERNATIONAL

Systemic AAV micro-dystrophin gene therapy for Duchenne muscular dystrophy

(2018) Dongsheng Duan   MOLECULAR THERAPY

Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing

(2018) Daniela Fraccarollo et al.   HYPERTENSION

A current approach to heart failure in Duchenne muscular dystrophy

(2017) Domenico D’Amario et al.   HEART

Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload–Induced Cardiac Hypertrophy and Dysfunction Through Modulating T-Cell ActivationNovelty and Significance

(2017) Chao Li et al.   HYPERTENSION

Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy

(2017) Mattia Quattrocelli et al.   JOURNAL OF CLINICAL INVESTIGATION

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor

(2017) Stefanie Ruhs et al.   JOURNAL OF ENDOCRINOLOGY

Gene expression effects of glucocorticoid and mineralocorticoid receptor agonists and antagonists on normal human skeletal muscle

(2017) Jessica A. Chadwick et al.   PHYSIOLOGICAL GENOMICS

Deletion of the Mineralocorticoid Receptor in Myeloid Cells Attenuates Central Nervous System Autoimmunity

(2017) Elena Montes-Cobos et al.   Frontiers in Immunology

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone

(2017) Miranda E. Good et al.   CIRCULATION RESEARCH

Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κB PathwaysSignificance

(2016) Jian-Yong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy

(2016) Jessica A. Chadwick et al.   HUMAN MOLECULAR GENETICS

Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Atherosclerosis by Affecting Foam Cell Formation and Efferocytosis

(2016) Zhu-Xia Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target

(2015) Jessica A. Chadwick et al.   FASEB JOURNAL

Anti-inflammatory macrophages improve skeletal muscle recovery from ischemia-reperfusion

(2015) David W. Hammers et al.   JOURNAL OF APPLIED PHYSIOLOGY

Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial

(2015) Subha V Raman et al.   LANCET NEUROLOGY

Immune-mediated pathology in Duchenne muscular dystrophy

(2015) Amy S. Rosenberg et al.   Science Translational Medicine

CCL2-Dependent Macrophage Recruitment Is Critical for Mineralocorticoid Receptor-Mediated Cardiac Fibrosis, Inflammation, and Blood Pressure Responses in Male Mice

(2014) J.Z. Shen et al.   ENDOCRINOLOGY

Post-translational modifications of the mineralocorticoid receptor: How to dress the receptor according to the circumstances?

(2014) Nourdine Faresse   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Prednisolone Attenuates Improvement of Cardiac and Skeletal Contractile Function and Histopathology by Lisinopril and Spironolactone in the mdx Mouse Model of Duchenne Muscular Dystrophy

(2014) Paul M. L. Janssen et al.   PLoS One

Myeloid Mineralocorticoid Receptor Deficiency Inhibits Aortic Constriction-Induced Cardiac Hypertrophy in Mice

(2014) Chao Li et al.   PLoS One

Glucocorticoid-induced skeletal muscle atrophy

(2013) O. Schakman et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Early Treatment With Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice

(2011) Jill A. Rafael-Fortney et al.   CIRCULATION

Mechanisms of ligand specificity of the mineralocorticoid receptor

(2011) Peter J Fuller et al.   JOURNAL OF ENDOCRINOLOGY

Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy

(2011) D. M. Escolar et al.   NEUROLOGY

Duchenne Muscular Dystrophy

(2010) John R. Bach et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

Steroid therapy is associated with decreased numbers of dendritic cells and fibroblasts, and increased numbers of satellite cells, in the dystrophic skeletal muscle

(2010) M. R. A. Hussein et al.   JOURNAL OF CLINICAL PATHOLOGY

The role of the glucocorticoid receptor in inflammation and immunity

(2010) Ulrike Baschant et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Myeloid-Specific Deletion of the Mineralocorticoid Receptor Reduces Infarct Volume and Alters Inflammation During Cerebral Ischemia

(2010) Ryan A. Frieler et al.   STROKE

Structure–function relationships in the mineralocorticoid receptor

(2008) Jyotsna B Pippal et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Systemic Microdystrophin Gene Delivery Improves Skeletal Muscle Structure and Function in Old Dystrophic mdx Mice

(2008) Paul Gregorevic et al.   MOLECULAR THERAPY

Mdx respiratory impairment following fibrosis of the diaphragm

(2008) Masatoshi Ishizaki et al.   NEUROMUSCULAR DISORDERS

Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice

(2007) Lan Zhou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES