Sex-biased and parental allele-specific gene regulation by KDM6A

Adipocyte Utx Deficiency Promotes High-Fat Diet-Induced Metabolic Dysfunction in Mice

(2022) Fenfen Li et al.   Cells

Clinical delineation, sex differences, and genotype–phenotype correlation in pathogenic KDM6A variants causing X-linked Kabuki syndrome type 2

(2021) Víctor Faundes et al.   GENETICS IN MEDICINE

Kabuki Syndrome—Clinical Review with Molecular Aspects

(2021) Snir Boniel et al.   Genes

Identification of KMT2D and KDM6A variants by targeted sequencing from patients with Kabuki syndrome and other congenital disorders

(2020) Chui-Sun Yap et al.   GENE

JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells

(2020) Yongli Shan et al.   Nature Communications

Lysine demethylase KDM6A in differentiation, development and cancer

(2020) Nhien Tran et al.   MOLECULAR AND CELLULAR BIOLOGY

A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

(2020) Emily J. Davis et al.   Science Translational Medicine

PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression

(2019) Claudia Gentile et al.   DEVELOPMENTAL CELL

Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid

(2019) Safiye E. Sarper et al.   Disease Models & Mechanisms

The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity

(2019) Yuichiro Itoh et al.   JOURNAL OF CLINICAL INVESTIGATION

Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development

(2019) Y. Lan et al.   JOURNAL OF DENTAL RESEARCH

Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects

(2019) Juan Yu et al.   Epigenetics & Chromatin

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

(2018) Malgorzata Gozdecka et al.   NATURE GENETICS

UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling

(2018) Xuepei Lei et al.   Stem Cell Reports

Novel KDM6A splice-site mutation in kabuki syndrome with congenital hydrocephalus: a case report

(2018) Zhimei Guo et al.   BMC Medical Genetics

Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells

(2018) Azusa Inoue et al.   GENES & DEVELOPMENT

Kabuki syndrome: international consensus diagnostic criteria

(2018) Margaret P Adam et al.   JOURNAL OF MEDICAL GENETICS

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription

(2017) Shu-Ping Wang et al.   MOLECULAR CELL

Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation

(2017) Masaki Yagi et al.   NATURE

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome

(2017) Karl B. Shpargel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterochromatin Reduction Correlates with the Increase of the KDM4B and KDM6A Demethylases and the Expression of Pericentromeric DNA during the Acquisition of a Transformed Phenotype

(2017) Cinthya Gurrion et al.   Journal of Cancer

Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells

(2017) Rachael J. Werner et al.   Biology of Sex Differences

UTX demethylase activity is required for satellite cell–mediated muscle regeneration

(2016) Hervé Faralli et al.   JOURNAL OF CLINICAL INVESTIGATION

Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells

(2016) Ferdinand von Meyenn et al.   MOLECULAR CELL

CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering

(2016) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

An essential role for UTX in resolution and activation of bivalent promoters

(2016) Shilpa S. Dhar et al.   NUCLEIC ACIDS RESEARCH

Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation

(2016) Rémy Bosselut   TRENDS IN IMMUNOLOGY

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

(2016) Staci L. Haney et al.   PLoS Genetics

Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murineHoxclusters in ES cells

(2015) Bony De Kumar et al.   GENOME RESEARCH

Escape from X Inactivation Varies in Mouse Tissues

(2015) Joel B. Berletch et al.   PLoS Genetics

The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation

(2015) Fan Yang et al.   GENOME BIOLOGY

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators

(2014) Daniel W. Bellott et al.   NATURE

Origins and functional evolution of Y chromosomes across mammals

(2014) Diego Cortez et al.   NATURE

Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells

(2014) Susan M. Byrne et al.   NUCLEIC ACIDS RESEARCH

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

KDM6 Demethylase Independent Loss of Histone H3 Lysine 27 Trimethylation during Early Embryonic Development

(2014) Karl B. Shpargel et al.   PLoS Genetics

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Utx Is Required for Proper Induction of Ectoderm and Mesoderm during Differentiation of Embryonic Stem Cells

(2013) Cristina Morales Torres et al.   PLoS One

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Female Bias in Rhox6 and 9 Regulation by the Histone Demethylase KDM6A

(2013) Joel B. Berletch et al.   PLoS Genetics

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

KDM6A Point Mutations Cause Kabuki Syndrome

(2012) Noriko Miyake et al.   HUMAN MUTATION

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

(2012) Abed AlFatah Mansour et al.   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

(2012) Karl B. Shpargel et al.   PLoS Genetics

UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program

(2011) Seunghee Lee et al.   DEVELOPMENTAL CELL

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity

(2011) Matthew D. Young et al.   NUCLEIC ACIDS RESEARCH

Precise BAC targeting of genetically polymorphic mouse ES cells

(2011) Tahsin Stefan Barakat et al.   NUCLEIC ACIDS RESEARCH

UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis

(2010) Shayesta Seenundun et al.   EMBO JOURNAL

Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression

(2010) Sara A. Miller et al.   MOLECULAR CELL

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Sex-Specific Differences in Expression of Histone Demethylases Utx and Uty in Mouse Brain and Neurons

(2008) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH