Article
Pharmacology & Pharmacy
Merel A. A. Opdam, Sophie Benoy, Lise M. Verhoef, Sandra Van Bijnen, Femke Lamers-Karnebeek, Rene A. M. Traksel, Petra Vos, Alfons A. den Broeder, Jasper Broen
Summary: Patients with inflammatory rheumatic diseases do not have an increased risk for COVID-19 compared to the general population. Older age and obesity are major risk factors for hospitalization for COVID-19 in patients with IRD, while the use of methotrexate may have a protective effect in reducing the risk of hospitalization.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Silvia Hayer, Margriet J. Vervoordeldonk, Maria C. Denis, Marietta Armaka, Markus Hoffmann, Johan Backlund, Kutty Selva Nandakumar, Birgit Niederreiter, Christina Geka, Anita Fischer, Nina Woodworth, Stephan Blueml, George Kollias, Rikard Holmdahl, Florence Apparailly, Marije Koenders
Summary: Animal models for inflammatory arthritides like rheumatoid arthritis and psoriatic arthritis are widely used for research, but many publications lack detailed descriptions and evaluations of arthritis pathology. The European consortium BeTheCure developed SMASH recommendations for standardised histological evaluation to improve information and promote reproducibility in preclinical research on inflammatory arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Immunology
Maarten M. Steinz, Aiarpi Ezdoglian, Fatemeh Khodadust, Carla F. M. Molthoff, Madduri Srinivasarao, Philip S. Low, Gerben J. C. Zwezerijnen, Maqsood Yaqub, Wissam Beaino, Albert D. Windhorst, Sander W. Tas, Gerrit Jansen, Conny J. van der Laken
Summary: Non-invasive imaging modalities, particularly macrophage imaging with folate-based PET tracers, hold great promise in diagnostic and therapy response monitoring of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Robert Landewe, Luna Sun, Yun-Fei Chen, Daojun Mo, Desiree van der Heijde
Summary: Demonstrating the inhibition of joint damage in rheumatoid arthritis trials is commonly achieved through statistically significant differences in radiographic progression measured by the mTSS. The frequently used ANCOVA+LE method for handling missing data may not be ideal for long-term extension or paediatric studies. The RC model shows better performance in terms of bias, RMSE, power and type I error rate, making it a more sensitive and precise alternative for analysing mTSS in studies with missing data.
Article
Nanoscience & Nanotechnology
Chaoxiong Wu, Jiale Cheng, Wei Li, Lingzhi Yang, Haifeng Dong, Xueji Zhang
Summary: A novel polymeric microneedle platform was developed for transdermal delivery of drugs and antioxidants for the treatment of rheumatoid arthritis (RA). This platform shows potential as an ideal choice for RA treatment combining chemotherapy and antioxidative therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medical Laboratory Technology
Muhammad Akram, Muhammad Daniyal, Sabira Sultana, Aymen Owais, Naheed Akhtar, Rabia Zahid, Fahad Said, Abdelhakim Bouyahya, Evgeny Ponomarev, Mohammad Ali Shariat, Muthu Thiruvengadam
Summary: Rheumatoid arthritis affects 1-2% of individuals aged 20-50 worldwide and is a leading cause of disability in developing and Western populations. Treatment options range from TNF-α blockade to traditional medicine, highlighting the importance of personalized multidisciplinary strategies based on pain and inflammation levels.
CLINICA CHIMICA ACTA
(2021)
Article
Pharmacology & Pharmacy
Susan J. Keam
Summary: Ozoralizumab (Nanozora (R)), a trivalent anti-TNF alpha NANOBODY (R) compound, has gained approval in Japan for the treatment of inadequately managed rheumatoid arthritis. This article provides an overview of the development milestones leading to this approval, including its development by Taisho Pharmaceutical Co. Ltd.
Review
Biochemistry & Molecular Biology
Chen Ma, Jie Wang, Fenfang Hong, Shulong Yang
Summary: This article reviews the methods, effects, etiology, and pathology of mitochondrial dysfunction leading to rheumatoid arthritis (RA). It also outlines drugs that can be used to treat RA by modulating mitochondrial activity. Understanding and summarizing mitochondrial dysfunction in RA may provide new research directions for intervening and preventing the disease.
Review
Biochemistry & Molecular Biology
Menglin Zhu, Qian Ding, Zhongxiao Lin, Rong Fu, Fuyuan Zhang, Zhaoyi Li, Mei Zhang, Yizhun Zhu
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint damage and disability, greatly impacting patients' quality of life. Although a complete cure is not currently possible, measures to relieve symptoms and reduce pain are used. RA can be induced by environmental factors, genes, and gender. Common treatments include non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids. Some biological agents have been used but often have side effects. Therefore, the search for new mechanisms and targets for treating RA is crucial.
Article
Thermodynamics
Malgorzata Gizinska, Radoslaw Rutkowski, Lucyna Szymczak-Bartz, Wojciech Romanowski, Anna Straburzynska-Lupa
Summary: The study developed a thermal imaging method to screen and differentiate joint inflammation in rheumatoid foot patients compared to a healthy control group. Significant differences in temperatures were found between the study group and controls, but not between left and right feet. Further research is needed to confirm the results.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Pharmacology & Pharmacy
Camilla Kofoed Andersen, Sangita Khatri, Jonas Hansen, Sofie Slott, Rohith Pavan Parvathaneni, Ana C. Mendes, Ioannis S. Chronakis, Shu-Chen Hung, Narendiran Rajasekaran, Zhuoran Ma, Shoujun Zhu, Hongjie Dai, Elizabeth D. Mellins, Kira Astakhova
Summary: PEGylated single-walled carbon nanotubes show high efficiency in serving as carriers for methotrexate and siRNA, enabling targeted delivery to immune cells. By altering the ratio of MTX and siRNA, the specificity of targeting to immune cells can be adjusted accordingly.