Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte

Gene expression profiles reveal effect of a high-fat diet on the development of white and brown adipose tissues

(2015) Hyeng-Soo Kim et al.   GENE

MiR-26b modulates insulin sensitivity in adipocytes by interrupting the PTEN/PI3K/AKT pathway

(2015) G Xu et al.   INTERNATIONAL JOURNAL OF OBESITY

A clerodane diterpene inhibit adipogenesis by cell cycle arrest and ameliorate obesity in C57BL/6 mice

(2015) Muheeb Beg et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

Diet-induced obesity causes insulin resistance in mouse brown adipose tissue

(2015) Carla Roberts-Toler et al.   Obesity

A major role of insulin in promoting obesity-associated adipose tissue inflammation

(2015) David J. Pedersen et al.   Molecular Metabolism

ROS production in brown adipose tissue mitochondria: The question of UCP1-dependence

(2014) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis

(2014) Koneni V. Sashidhara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Vascular rarefaction mediates whitening of brown fat in obesity

(2014) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Exposure to excess insulin (glargine) induces type 2 diabetes mellitus in mice fed on a chow diet

(2014) Xuefeng Yang et al.   JOURNAL OF ENDOCRINOLOGY

Berberine activates thermogenesis in white and brown adipose tissue

(2014) Zhiguo Zhang et al.   Nature Communications

Brown adipose tissue transplantation improves whole-body energy metabolism

(2013) Xiaomeng Liu et al.   CELL RESEARCH

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

(2013) Janne Orava et al.   Obesity

Type 2 Diabetes Mellitus in Children and Adolescents

(2013) K. Dileepan et al.   PEDIATRICS IN REVIEW

Mechanisms of insulin resistance in obesity

(2013) Jianping Ye   Frontiers of Medicine

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

The adipose organ at a glance

(2012) S. Cinti   Disease Models & Mechanisms

Programming human pluripotent stem cells into white and brown adipocytes

(2012) Tim Ahfeldt et al.   NATURE CELL BIOLOGY

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Insulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse

(2011) Jie Ning et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Age-Related Decrease in Cold-Activated Brown Adipose Tissue and Accumulation of Body Fat in Healthy Humans

(2011) Takeshi Yoneshiro et al.   Obesity

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

Differentiation of human adipose-derived stem cells into “brite” (brown-in-white) adipocytes

(2011) Didier F. Pisani   Frontiers in Endocrinology

A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

(2010) Paul Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

(2010) C. Pfannenberg et al.   DIABETES

Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling

(2010) Sarah L. Gray et al.   ENDOCRINOLOGY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Quantification of Cells Expressing Mesenchymal Stem Cell Markers in Healthy and Osteoarthritic Synovial Membranes

(2010) T. HERMIDA-GOMEZ et al.   JOURNAL OF RHEUMATOLOGY

Hyperleptinemia Is Required for the Development of Leptin Resistance

(2010) Zachary A. Knight et al.   PLoS One

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

UCP1: its involvement and utility in obesity

(2009) L P Kozak et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin Is a Stronger Inducer of Insulin Resistance than Hyperglycemia in Mice with Type 1 Diabetes Mellitus (T1DM)

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes

(2009) Christian Elabd et al.   STEM CELLS

Development of hyperinsulinemia and insulin resistance during the early stage of weight gain

(2008) Johannes Erdmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE