期刊
POLYMERS
卷 14, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/polym14163322
关键词
PGA-PLA block copolymer; bio-resorbable; in vivo degradation test; histochemical analysis
资金
- Technology Innovation Program - Ministry of Trade, Industry & Energy (MOTIE, Korea) [10077004]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10077004] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Polylactic acid and polyglycolic acid are widely used medical-implant materials. Researchers have synthesized a PGA-PLA block copolymer with good biocompatibility and a controlled biodegradation rate, making it suitable for use in resorbable spinal-fixation materials.
Polylactic acid (PLA) and polyglycolic acid (PGA) are well-known medical-implant materials. Under the consideration of the limitations of degradable polymeric materials, such as weak mechanical strength and by-product release through the biodegradation process under in vivo environments, PLA-PGA block copolymer is one of the effective alternative implant materials in the clinical field. In our previous study, two types of extremely effective PGA-PLA copolymers (multi/tri-block PGA-PLA copolymers) were synthesized. These synthesized block copolymers could overcome aforementioned issues and also showed good biocompatibility. In this study, the PGA-PLA block copolymers with large molecular weight were synthesized under the same chemical scheme, and their bio durability was confirmed through the in vivo degradation behavior and histochemical analyses (by hematoxylin and eosin and immune staining) in comparison with commercial PLGA random copolymer (medical grade). Specimens for the degradation test were investigated by SEM and X-ray diffractometer (XRD). As a result, the synthesized PGA-PLA block copolymer showed good biocompatibility and had a controlled biodegrading rate, making it suitable for use in resorbable spinal-fixation materials.
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